Mariners vs Astros Prediction 5/13/26 MLB Picks Today

In this article, we will formulate a Mariners vs Astros Prediction for this MLB matchup on Wednesday, May 13^th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Houston Astros Preview

The Houston Astros have a 16-27 record this season and are sitting in the fifth place of the AL West. They have a 9-12 home record and are coming off a 2-10 loss at home against the Mariners. They will face the Rangers and the Twins next.

The Astros have a .255 batting average this season, .330 OBP and .421 Slugging percentage. Houston’s pitching staff has a 5.61 ERA and 1.59 WHIP. Yordan Alvarez is the team’s best hitter with a .308 batting average, also leading the team in RBI with 29 and adding a team‑high 13 home runs.

Lance McCullers Jr. (R) is the projected starting pitcher for the Astros, and he has a 2-3 record, 7.41 ERA and 1.50 WHIP.

Seattle Mariners Preview

The Seattle Mariners have a 21-22 record this season and are sitting in the second place of the AL West. They have a 9-11 away record and are coming off a 10-2 win on the road against the Astros. They will face the White Sox and the Padres next.

The Mariners have a .231 batting average this season, .320 OBP and .380 Slugging percentage. Seattle’s pitching staff has a 3.67 ERA and 1.22 WHIP. Randy Arozarena is the team’s best hitter with a .303 batting average. Luke Raley leads the team in RBI with 23, also adding a team‑high 8 home runs.

Bryce Miller (R) is the projected starting pitcher for the Mariners and last season he had a 4-6 record, 5.68 ERA and 1.41 WHIP.

Seattle Mariners @ Houston Astros Betting Trends: May 13, 2026

• Probable Starting Pitcher: Lance McCullers Jr.      Record this season: 2-3      ERA: 7.41
• Home Record: 1-3
• Last 5 against Mariners: 1-0

Why the Houston Astros will win

• The Astros have won each of their last five Wednesday games as underdogs against American League opponents.
• The Mariners have lost six of their last eight games as favorites against American League opponents following a road win.
• The Mariners have failed to cover the run line in each of their last six Wednesday night road games against American League opponents.
• The Astros have covered the run line in seven of their last eight Wednesday home games.
• The Astros have led after 3 innings in each of their last five Wednesday games against the Mariners at Daikin Park.
• The Astros have won the first inning in seven of their last eight Wednesday home games.

• Probable Starting Pitcher: Bryce Miller      Record this season: –      ERA: –
• Road Record: –
• Last 5 against Astros: 3-1

Why the Seattle Mariners will win

• The Mariners have won each of their last nine games against the Astros.
• The Astros have lost each of their last eight games against the Mariners following a loss.
• The Astros have failed to cover the run line in each of their last eight night games against the Mariners at Daikin Park following a home loss.
• The Mariners have covered the run line in eight of their last nine games against the Astros.
• The Mariners have led after 3 innings in five of their last six games at Daikin Park.
• The Astros have trailed after 5 innings in each of their last seven night games at Daikin Park against AL West opponents.

Total Runs Facts

• Nine of the Astros’ last 10 home games against American League opponents have gone OVER the total runs line.
• Five of the Mariners’ last six games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of Lance McCullers Jr.’s last six home appearances as a starter.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Mariners’ last 12 games against AL West opponents.

Houston Astros Player Prop Facts

• Lance McCullers Jr. has recorded six or more strikeouts in each of his last five home appearances against the Mariners.
• Jeremy Pena has hit a home run in two of his last three appearances with the Astros as home underdogs.
• Jeremy Pena has recorded at least one hit in each of his last 10 Wednesday appearances at Daikin Park.
• Yordan Alvarez ranks T5th in the league in Hits (49) this season.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit a home run in three of the Mariners’ last five games against AL West opponents.
• Bryce Miller has recorded five or more strikeouts in eight of his nine previous appearances in night games against AL West teams that held a losing record.
• Randy Arozarena has recorded at least one hit in each of the Mariners’ last nine road games against AL West opponents that held a losing record.
• Randy Arozarena ranks T9th in the league in Steals (10) this season.

Matchup/League Facts

• The Astros rank 30th in the league for ERA this season (5.61).
• The Astros rank 30th in the league for walks allowed this season (217).
• The Mariners rank 1st in the league for walks allowed this season (105).
• The Mariners rank 27th in the league for strikeouts against this season (390).

Mariners vs Astros Prediction

The Mariners have won their last 9 meetings against the Astros and have won their last five visits in Houston. Over is 6-2 in their last 8 meetings.

In this Mariners vs Astros Prediction, the Mariners are coming as -125 road favorites. Bryce Miller will make his season debut for the Mariners after a terrible campaign last season and he will go up against Lance McCullers Jr. who has been bad this season, having given up at least three runs in each of his last six starts and was torched in his previous start against the Mariners this season. On top of that, the Astros have the worst bullpen in baseball and both teams are better against righties, with 9.8 runs/9 combined, so I expect a high-scoring affair. Take the over 9 in this one.