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Mariners vs Reds Prediction 7/22/26 MLB Picks Today

Cincinnati Reds (46-54) vs. Seattle Mariners (51-51)
July 22, 2026 3:40 pm EDT
The Line: Seattle Mariners -148 / Cincinnati Reds 123; Over/Under: 8
(Get latest betting odds)

The Cincinnati Reds and Seattle Mariners meet Wednesday in MLB action at T-Mobile Park. Here’s a Mariners vs Reds Prediction. This article will include a Mariners vs Reds Pick.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 46-54 on the year and play the Guardians and Cardinals next. The Cincinnati Reds are batting .230 on the season, have a .309 OBP, and have a .399 slugging percentage. The Cincinnati Reds’ pitching staff has a 4.58 ERA and a 1.44 WHIP. Sal Stewart leads the Cincinnati Reds with 95 hits and 71 RBI, while Elly De La Cruz and Spencer Steer have combined for 171 hits and 86 RBI.

Brady Singer gets the ball for the Cincinnati Reds, and he is 4-9 with a 4.56 ERA and 82 strikeouts this season. Singer is 1-2 with a 3.93 ERA and 40 strikeouts in his career against the Seattle Mariners.

Seattle Mariners Betting Preview

The Seattle Mariners are 51-51 on the year and play the Rangers and Dodgers next. The Seattle Mariners are batting .229 on the season, have a .310 OBP, and have a .378 slugging percentage. The Seattle Mariners’ pitching staff has a 3.58 ERA and a 1.17 WHIP. Randy Arozarena leads the Seattle Mariners with 96 hits and 45 RBI, while Cole Young and Josh Naylor have combined for 188 hits and 85 RBI.

Emerson Hancock gets the ball for the Seattle Mariners, and he is 6-4 with a 3.17 ERA and 94 strikeouts this season. This will be Hancock’s second career game against the Cincinnati Reds.

Why the Seattle Mariners will win

  • The Reds have lost each of their last seven games following a win.
  • The Mariners have won eight of their last nine home games following a loss.
  • The Mariners have covered the run line each of their last seven day games against teams that held a losing record.
  • The Reds have failed to cover the run line in each of their last four games following a road win.
  • The Reds have lost the first inning in each of their last five Wednesday road games.
  • The Mariners have led after 5 innings in four of their last five home day games.
  • The Mariners have led after 3 innings in 13 of their last 17 day games against opponents that held a losing record.

Why the Cincinnati Reds will win

  • The Mariners have lost four of their last five games as favorites against National League opponents following a loss.
  • The Reds have won three of their last four games as road underdogs.
  • The Mariners have failed to cover the run line in seven of their last eight day games against National League opponents.
  • The Reds have covered the run line in five of their last six day games against American League opponents.
  • The Reds have won the first inning in three of their last four games as road underdogs.
  • The Reds have led after 5 innings in six of their last seven day games against American League opponents.
  • The Mariners have trailed after 3 innings in five of their last six games as favorites against NL Central opponents.

Total Runs Facts

  • Six of the Reds’ last seven day games after playing the previous day have gone OVER the total runs line.
  • Four of the Mariners’ last five games as favorites against NL Central opponents have gone UNDER the total runs line.
  • There has been at least one run scored in the first inning in eight of the Reds’ last nine road games.
  • There has been no run scored during the first inning in 14 of the Mariners’ last 16 games.

Seattle Mariners Player Prop Facts

  • Cal Raleigh has hit at least one home run in three of the Mariners’ last four games against the Reds.
  • Emerson Hancock has recorded six or more strikeouts in each of his last three home appearances against NL opponents.
  • Josh Naylor has recorded at least one hit in each of his last 17 home appearances against NL Central opponents that held a losing record.
  • Josh Naylor ranks T10th in the league in Steals (20) this season.

Cincinnati Reds Player Prop Facts

  • Brady Singer has recorded six or more strikeouts in each of his last five appearances against the Mariners.
  • Sal Stewart has recorded at least one hit in each of the Reds’ last eight Wednesday games.
  • Nathaniel Lowe has hit a home run in three of his last four appearances.
  • Elly De La Cruz is one of only seven players to record 10+ Home Runs and 4+ Triples this season.

Matchup/League Facts

  • The Mariners rank 30th in the league for doubles this season (123).
  • The Mariners rank 30th in the league for doubles this season (123).
  • The Reds rank 29th in the league for hits this season (769).
  • The Reds rank 29th in the league for hits this season (769).

Mariners vs Reds Prediction

The Reds have had issues stringing wins together and aren’t a team I’m excited to back after a win. Singer is having a strong July, but he’s on the road where he has a 6.14 ERA and .311 batting average allowed. The Mariners are showing flashes of playing to their potential, and Hancock has been great lately, allowing 7 hits and 1 run in his last 14.1 innings. In 52.1 innings at home, Hancock has a 2.92 ERA and a .191 allowed batting average. The price is fair. I’m rolling with the Mariners.

Randy Chambers's Free Pick: Seattle Mariners -148

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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