Marlins vs Cardinals Prediction 4/21/26 MLB Picks Today

In this article we will formulate a Marlins vs Cardinals prediction for this MLB game on Tuesday, April 21st at loanDepot park in Miami, Florida. Let’s take a look at the prediction for this MLB matchup. 

Miami Marlins Betting Preview

The Miami Marlins are 11-12 this year after they won game one by a score of 5-3 on Monday night. Miami was tied at two in the sixth inning, but they scored two runs in the sixth and added another in the eighth for the win. The Marlins recorded six hits in the game and they were led by Hicks, who went 2-4 with two RBIs. Meyer allowed three hits and two earned runs over 5.1 innings, while Faucher picked up the win and Fairbanks got the save. Prior to this series, Miami lost two out of three against the Brewers and two out of three against the Braves. 

This season, Miami has a 4.01 ERA with a 1.25 WHIP and a .216 opponent batting average, while they have scored 105 runs with a .254 batting average and a .330 on base percentage. Liam Hicks has led the Marlins with four home runs and 21 RBIs, while Owen Caissie has added two home runs and 13 RBIs. The projected starting pitcher for Miami is Chris Paddack, who is 0-3 with a 5.59 ERA and a 1.45 WHIP over 19.1 innings pitched this year. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 13-9 this season after they lost game one by a score of 5-3 on Monday night. St. Louis led 1-0 in the fourth and they were tied at two in the sixth, but didn’t score again until the ninth for the loss. The Cardinals recorded five hits in the game and they were led by Winn and Urias, who both had one RBI. McGreevy allowed five hits and four earned runs over 5.2 innings for the loss, while Fernandez allowed one earned run in relief. Prior to this series, St. Louis swept the Astros in three games and won two out of three against the Guardians. 

This season, St. Louis has a 4.83 ERA with a 1.41 WHIP and a .255 opponent batting average, while they have scored 103 runs with a .233 batting average and a .328 on base percentage. Jordan Walker has led the Cardinals with eight home runs and 16 RBIs, while Alec Burleson has added three home runs and 15 RBIs. The projected starting pitcher for St. Louis is Dustin May, who is 2-2 with a 6.98 ERA and a 1.60 WHIP over 19.1 innings pitched this season. 

Why the Miami Marlins will win

• The Marlins have won each of their last five games against National League opponents following a home win.
• The Cardinals have lost six of their last eight road games against National League opponents.
• The Cardinals have failed to cover the run line in four of their last five games as road underdogs against National League opponents.
• The Marlins have covered the run line in four of their last five home games after playing the previous day.
• The Cardinals have trailed after 5 innings in each of their last six games as road underdogs against National League opponents.

Why the St. Louis Cardinals will win

• The Marlins have lost each of their last seven Tuesday night games as home favorites against NL Central opponents.
• The Cardinals have won each of their last four games as road underdogs against NL East opponents following a loss.
• The Marlins have failed to cover the run line in each of their last 15 Tuesday night games as favorites against National League opponents.
• The Cardinals have covered the run line in each of their last six night games at LoanDepot Park following a loss.
• The Cardinals have led after 5 innings in four of their last five road games.

Total Runs Facts

• Seven of the Cardinals’ last eight games as underdogs have gone OVER the total runs line.
• Three of the Marlins’ last four night games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Marlins’ last eight night games at LoanDepot Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Cardinals’ last five night games.

Miami Marlins Player Prop Facts

• Kyle Stowers has hit at least one home run in eight of his last 21 home appearances.
• Chris Paddack has recorded seven or more strikeouts in four of his five previous appearances in night games against NL Central teams that held a winning record.
• Agustin Ramirez has recorded a hit in each of the Marlins’ last seven night games against NL Central opponents that held a winning record.
• Xavier Edwards ranks T2nd in the league in Hits (28) this season.

St. Louis Cardinals Player Prop Facts

• Dustin May has recorded five or more strikeouts in four of his last five appearances against NL opponents that held a losing record.
• Lars Nootbaar has hit a home run in three of his last four Tuesday appearances against NL East teams that held a losing record.
• Lars Nootbaar has recorded at least one hit in each of his last nine road appearances against NL East opponents.
• Jordan Walker ranks T3rd in the league in Home Runs (8) this season.

Matchup/League Facts

• The Marlins rank 1st in the league for triples this season (8).
• The Marlins rank 28th in the league for home runs this season (15).
• The Cardinals rank 30th in the league for strikeouts this season (136).
• The Cardinals rank T29th in the league for triples this season (0).

Marlins vs Cardinals Prediction 

St. Louis had their winning streak snapped on Monday night, but they have scored at least five runs in four of their last five games. The Cardinals are 6-4 on the road this year, while the Marlins are 9-5 at home. Miami has won two in a row and they have scored five runs in three of their last four. The Marlins are starting Paddack, who has allowed two earned runs or fewer in three straight starts, while May has allowed 1, 1, 7, and 6 earned runs in his four outings. I don’t trust either starter in this game, but Paddack has at least put together three decent starts. Take the Marlins at home.