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Marlins vs White Sox Prediction 4/1/26 MLB Picks Today

Chicago White Sox (1-4) vs. Miami Marlins (4-1)
April 1, 2026 1:10 pm EDT
The Line: Miami Marlins -156 / Chicago White Sox 129; Over/Under: 7.5
(Get latest betting odds)

In this article we will formulate a Marlins vs White Sox prediction for this MLB game on Wednesday, April 1st at loanDepot park in Miami, Florida. Let’s take a look at the prediction for this MLB matchup. 

Miami Marlins Betting Preview

The Miami Marlins are 4-1 this year after they split the first two games in this series by scores of 4-9 and 9-2. In the game two win, Miami trailed 2-0 in the third inning, but they rallied with nine unanswered runs to pull away for the blowout win. The Marlins recorded nine hits in the game and they were led by Conine, Caissie, and Hicks, who all had two RBIs. Junk allowed five hits and two earned runs over 4.1 innings in the no decision, while Bender picked up the win in relief. 

This season, Miami has a 3.40 ERA with a 0.93 WHIP and a .200 opponent batting average, while they have scored 23 runs with a .276 batting average and a .350 on base percentage. Liam Hicks has led the Marlins with two home runs and eight RBIs, while Owen Caissie has added one home run and six RBIs. The projected starting pitcher for Miami is Sandy Alcantara, who is 1-0 with a 0.00 ERA and a 0.86 WHIP over 7.0 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 1-4 this season after they lost game two in this series by a score of 9-2 on Tuesday. Chicago scored two runs in the third inning to take an early lead, but their offense went silent after that in the lopsided loss. The White Sox recorded five hits and they committed three errors in the game, while they were led by Murakami and Benintendi, who both had one RBI. Fedde allowed six hits and three earned runs over 5.0 innings for the loss, while Paez allowed three earned runs in relief. 

This season, Chicago has a 8.34 ERA with a 1.98 WHIP and a .312 opponent batting average, while they have scored 21 runs with a .209 batting average and a .290 on base percentage. Miguel Vargas has led the White Sox with one home run and six RBIs, while Colson Montgomery has added one home runs and five RBIs. The projected starting pitcher for Chicago is Shane Smith, who is 0-1 with a 16.20 ERA and a 3.00 WHIP over 1.2 innings pitched this season. 

Why the Miami Marlins will win

  • The White Sox have lost nine of their last 10 road games against teams that held a winning record.
  • The Marlins have won eight of their last nine games against teams that held a losing record.
  • The Marlins have covered the run line in six of their last seven day games against American League opponents that held a losing record.
  • The White Sox have failed to cover the run line in five of their last six games against teams that held a winning record.
  • The White Sox have trailed after 5 innings in each of their last five Wednesday road games.

Why the Chicago White Sox will win

  • The White Sox have won seven of their last eight games as underdogs against NL East opponents following a loss.
  • The Marlins have lost each of their last 12 Wednesday day games against teams that held a losing record.
  • The White Sox have covered the run line in each of their last eight games against NL East opponents following a loss.
  • The Marlins have failed to cover the run line in each of their last six games following a win.
  • The White Sox have led after 3 innings in seven of their last eight games against the Marlins.
  • The White Sox have won the first inning in each of their last three day games.
  • The White Sox have led after 5 innings in four of their last five games at LoanDepot Park.

Total Runs Facts

  • Each of the Marlins’ last five day games after playing the previous day have gone UNDER the total runs line.
  • Five of the White Sox’s last six games after playing the previous day have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Marlins’ last six games against American League opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the White Sox’s last five games at LoanDepot Park.

Miami Marlins Player Prop Facts

  • Sandy Alcantara has recorded seven or more strikeouts in each of his last three appearances against opponents that held a losing record.
  • Sandy Alcantara has recorded a win in each of his last four appearances.
  • Xavier Edwards has recorded at least one hit in each of the Marlins’ last 14 games against AL Central opponents that held a losing record.
  • Kyle Stowers has hit at least one home run in four of his last seven home appearances against AL Central opponents.

Chicago White Sox Player Prop Facts

  • Austin Hays has hit a home run in two of his last three appearances with his team as an underdog against the Marlins.
  • Miguel Vargas has recorded at least one hit in seven of his last eight appearances in day games against teams that held a winning record.

Marlins vs White Sox Prediction 

Chicago comes into this matchup after starting the season with some very poor pitching, as they have allowed 6+ runs in four of their five games. The White Sox are starting Smith, who was terrible in his first outing. Miami has allowed three runs or fewer in four of their first five games and they are starting Alcantara, who pitched well against the lowly Rockies in his first start. I think the Marlins will win, but I have to keep riding the over with this White Sox pitching staff. Take the over here. 

David Racey's Free Pick: Over 7.5

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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