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Marlins vs Padres Prediction 7-22-25 MLB Picks

San Diego Padres (55-45) vs. Miami Marlins (46-53)
July 22, 2025 10:40 pm EDT
The Line: Miami Marlins -115 / San Diego Padres -105; Over/Under: 8
(Get latest betting odds)

The San Diego Padres and the Miami Marlins meet Tuesday in MLB action from LoanDepot Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Marlins vs Padres Prediction.

Starting Pitching Matchup

The San Diego Padres will send out Stephen Kolek for the start here and Kolek is 3-4 with a 4.24 ERA and 49 strikeouts this season. This will be Kolek’s second career start against the Marlins. Edward Cabrera will get the nod for the Marlins here and is 3-4 with a 3.61 ERA and 86 strikeouts this season. In his career, Cabrera is 0-0 with a 0.00 ERA and 11 strikeouts against the Padres.

San Diego Padres Recap

The San Diego Padres will be out to add on to their 2-1 win over the Marlins from Monday’s series opener to sit at 55-45 on the year. After this series, the Padres will head on the road for a series against the St. Louis Cardinals.

Padres Win Back-To-Back Games

Manny Machado has 109 hits including a team-high 23 doubles, 18 home runs, 60 RBIs and 8 stolen bases while Fernando Tatis Jr. has 97 hits with a team-high 16 home runs and 42 RBIs along with 22 stolen bases of his own this season. Luis Arraez has added 107 hits with 17 doubles, 4 triples, 5 home runs and 36 RBIs while Jackson Merrill’s added 65 hits with 7 home runs and 32 RBIs as well. Xander Bogaerts also has 20 doubles and 16 stolen bases as well this season. Gavin Sheets also has 15 doubles, 14 home runs and 51 RBIs as well this season.

Why the San Diego Padres will win

  • The Marlins have lost each of their last five games as home favorites.
  • The Padres have won each of their last four games as underdogs against the Marlins.
  • The Marlins have failed to cover the run line in 28 of their last 29 games as home favorites against National League opponents.
  • The underdogs have covered the run line in 10 of the Marlins’ last 11 games at LoanDepot Park.

San Diego Padres Player Prop Facts

  • Martin Maldonado has recorded a Double in each of his last three appearances with his team as an underdog against the Marlins.
  • Manny Machado has hit a home run in three of the Padres’ last five night games.
  • Luis Arraez has recorded at least one hit in each of his last 10 appearances at LoanDepot Park against opponents that held a losing record.
  • Manny Machado ranks T8th in the league in Hits (109) this season.

Miami Marlins Recap

The Miami Marlins come into this game looking to rebound from their loss at the hands of the Padres on Monday to sit at 46-53 on the year. After this series, the Marlins will head on the road for a series against the Milwaukee Brewers.

Marlins Drop Back-To-Back Games

Xavier Edwards has 96 hits including 16 doubles and a team-high 16 stolen bases while Eric Wagaman has 78 hits with 20 doubles. Otto Lopez has 77 hits with 11 doubles and 11 home runs with 52 RBIs. Kyle Stowers has 93 hits with 14 doubles, 3 triples, 21 home runs and 59 RBIs but also has 100 strikeouts so far this season. Agustin Ramirez also has 14 home runs, 21 doubles and 44 RBIs and Jesus Sanchez has chipped in 32 RBIs as well on the year.

Why the Miami Marlins will win

  • The Padres have lost eight of their last nine games following a road win.
  • The Marlins have won six of their last seven games against NL West opponents.
  • The Marlins have covered the run line in eight of their last nine games following a home loss.
  • The Padres have failed to cover the run line in six of their last seven games against NL East opponents following a road win.

Miami Marlins Player Prop Facts

  • Edward Cabrera has recorded six or more strikeouts in each of his three previous appearances with the Marlins as favorites against NL West opponents.
  • Kyle Stowers has hit a home run in three of the Marlins’ last four games against NL West opponents that held a winning record.
  • Otto Lopez has recorded at least one hit in each of the Marlins’ last eight games against the Padres.
  • Kyle Stowers ranks 6th amongst qualified players for Slugging Percentage (.564) this season.

Total Runs Facts

  • Each of the Padres’ last seven night games as underdogs have gone UNDER the total runs line.
  • Each of the Marlins’ last four games as home favorites have gone UNDER the total runs line.

Marlins vs Padres Prediction

I’m on the Marlins here. I get the case to be made for the Padres after sneaking one out in Monday’s opener, but I think that Cabrera is the far better option here. The Marlins should be able to get some back on Tuesday. The Marlins had chances offensively in Monday’s game, but the thing is that I don’t think that the Padres will have the same luck with Kolek going here. I’ll roll with the Marlins in this one.

Chris Ruffolo's Free Pick: Miami Marlins -115

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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