Nationals vs Cardinals Prediction 5/10/25 MLB Picks Today

The St. Louis Cardinals and Washington Nationals meet Saturday in MLB action at Nationals Park. Here’s a Nationals vs Cardinals Prediction. This article will include a Nationals vs Cardinals Pick.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 20-19 on the year and play the Phillies, Royals, and Tigers next. The St. Louis Cardinals are batting .262 on the season, have a .337 OBP, and a .402 slugging percentage. The St. Louis Cardinals pitching staff has a 3.97 ERA and a 1.25 WHIP. Brendan Donovan leads the St. Louis Cardinals with 47 hits and 19 RBI, while Willson Contreras and Nolan Arenado have combined for 72 hits and 36 RBI.

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 2-2 with a 4.75 ERA and 21 strikeouts this season. Pallante is 1-1 with a 7.36 ERA and 9 strikeouts in his career against the Washington Nationals.

Washington Nationals Betting Preview

The Washington Nationals are 17-22 on the year and play the Braves, Orioles, and Braves next. The Washington Nationals are batting .241 on the season, have a .311 OBP, and a .382 slugging percentage. The Washington Nationals pitching staff has a 5.47 ERA and a 1.46 WHIP. James Wood leads the Washington Nationals with 42 hits and 23 RBI, while Keibert Ruiz and Nathaniel Lowe have combined for 73 hits and 42 RBI.

Trevor Williams gets the ball for the Washington Nationals, and he is 2-3 with a 5.86 ERA and 30 strikeouts this season. Williams is 5-6 with a 4.93 ERA and 82 strikeouts in his career against the St. Louis Cardinals.

Why the Washington Nationals will win

• The Cardinals have lost seven of their last eight games as road favorites after playing the previous day.
• The Nationals have won four of their last five games as home underdogs against National League opponents following a home loss.
• The Cardinals have failed to cover the run line in 12 of their last 13 games as favorites following a road win.
• The Nationals have covered the run line in six of their last seven games against National League opponents following a home loss.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last six games.
• The Nationals have lost each of their last four home games against NL Central opponents.
• The Cardinals have covered the run line in each of their last six games.
• The Nationals have failed to cover the run line in four of their last five games at Nationals Park.
• The Cardinals have won the first inning in five of their last six road games against National League opponents.
• The Nationals have trailed after 5 innings in eight of their last nine games as underdogs against National League opponents.
• The Nationals have trailed after 3 innings in eight of their last nine games as underdogs against National League opponents.

Washington Nationals Player Prop Facts

• Josh Bell has hit a home run in each of his last two appearances against NL Central opponents that held a winning record.
• Trevor Williams has recorded a win in three of his last four home appearances against NL opponents.
• Josh Bell has recorded at least one RBI in five of his last six home appearances against NL Central opponents that held a winning record.
• Josh Bell has scored at least one run in eight of his last nine appearances in day games against NL teams that held a winning record.
• CJ Abrams has recorded at least one Single in nine of the Nationals’ last 10 games as underdogs against NL opponents.
• Trevor Williams has recorded four or more strikeouts in each of his last nine home appearances.
• CJ Abrams has recorded at least one hit in each of the Nationals’ last 11 games against NL opponents that held a winning record.
• James Wood ranks T7th in the league in Home Runs (10) this season.

St. Louis Cardinals Player Prop Facts

• Willson Contreras has hit a home run in five of his last seven appearances with the Cardinals as favorites against the Nationals.
• Willson Contreras has recorded at least one RBI in each of the Cardinals’ last four games against NL East opponents.
• Willson Contreras has scored at least one run in each of his last seven appearances with the Cardinals as favorites against the Nationals.
• Willson Contreras has recorded at least one Single in each of the Cardinals’ last nine games against NL East opponents.
• Willson Contreras has recorded at least one hit in each of the Cardinals’ last 10 games against NL East opponents.
• Victor Scott II ranks T6th in the league in Steals (11) this season.

Nationals vs Cardinals Prediction

The Cardinals are rolling with six straight wins and a pitching staff that’s produced back-to-back shutouts and allowed a combined one run in their last three games. The Nationals pitching staff has bee getting rocked during this losing stretch, and Williams has played a role in those struggles. Through 35.1 innings, Williams has a 5.86 ERA and .317 allowed batting average. It’s not much better at home in 15.1 innings, as Williams has a 5.28 ERA and .271 allowed batting average.

Pallante has had his issues on the season, especially on the road, where he has a 5.66 ERA and .289 allowed batting average in 20.2 innings. However, the Cardinals are arguably the hottest team in baseball this week. I’ll trust that and lay the cheap price with the road team.