Nationals vs Cubs Prediction 3/28/26 MLB Picks Today

In this article, we will formulate a Nationals vs Cubs Prediction for this MLB matchup on Saturday, March 28^th. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have a 0-1 record this season and are sitting in last place of the NL Central. They are coming off a 10-4 home defeat by the Nationals and their previous three games were an 8-3 home loss to the Yankees, a 15-6 home win over the Yankees, and a 12-0 home win over the Brewers in spring training.

The Cubs have a .235 batting average this season, .350 OBP and .294 Slugging percentage. Chicago’s pitching staff has a 8.00 ERA and 1.44 WHIP. Michael Busch is the team’s best hitter with a .750 batting average, while Pete Crow-Armstrong leads the team in RBI with 2.

Cade Horton (R) is the projected starting pitcher for the Cubs, and last season he had a 11-4 record, 2.67 ERA and 1.08 WHIP.

Washington Nationals Preview

The Washington Nationals have a 1-0 record this season and are sitting in first place of the NL East. They are coming off a 10-4 away win over the Cubs and their previous three games were a 2-0 home loss to the Orioles, an 8-1 away loss to the Orioles, and a 3-1 home win over the Mets in spring training.

The Nationals have a .297 batting average this season, .350 OBP and .568 Slugging percentage. Washington’s pitching staff has a 3.00 ERA and 1.56 WHIP. Joey Wiemer is the team’s best hitter with a 1.000 batting average. CJ Abrams leads the team in RBI with 2, and Jacob Young added a team-high one home run.

Miles Mikolas (R) is the projected starting pitcher for the Nationals, and last season he had an 8-11 record, 4.84 ERA and 1.32 WHIP.

Washington Nationals @ the Chicago Cubs Betting Trends: March 28, 2026

• Probable Starting Pitcher: Cade Horton      Record this season: –      ERA: –
• Home Record: –
• Last 5 against Nationals: 1-0

Why the Chicago Cubs will win

• The Cubs have won nine of their last 10 day games following a home loss.
• The Nationals have lost six of their last seven games following a win.
• The Cubs have covered the run line in seven of their last eight home games against National League opponents following a home loss.
• The Nationals have failed to cover the run line each of their last six Saturday day games against teams that held a losing record.
• The Cubs have led after 3 innings in seven of their last eight games as home favorites against NL East opponents.
• The Cubs have led after 5 innings in seven of their last eight games as favorites.
• The Nationals have lost the first inning in three of their last four day games against NL Central opponents that held a losing record.

• Probable Starting Pitcher: Miles Mikolas      Record this season: –      ERA: –
• Road Record: –
• Last 5 against Cubs: 1-4

Why the Washington Nationals will win

• The Nationals have won five of their last six games as underdogs against NL Central opponents.
• The Cubs have lost four of their last five games as home favorites against NL East opponents.
• The Nationals have covered the run line in each of their last 13 Saturday day games as road underdogs against National League opponents.
• The Cubs have failed to cover the run line in eight of their last nine day games against NL East opponents.
• The Nationals have led after 3 innings in three of their last four games at Wrigley Field against opponents that held a losing record.
• The Nationals have led after 5 innings in each of their last five day games against National League opponents.

Total Runs Facts

• Each of the Cubs’ last five home games against NL East opponents have gone OVER the total runs line.
• Six of the Nationals’ last seven road games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Cubs’ last six games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the Nationals’ last five games against NL Central opponents.

Chicago Cubs Player Prop Facts

• Ian Happ has recorded a Double in each of the Cubs’ last four games against NL East opponents that held a winning record.
• Seiya Suzuki has recorded at least one hit in each of his last 14 home appearances.
• Seiya Suzuki has hit a home run in four of his last six appearances with the Cubs as favorites.
• Nico Hoerner ranked 6th in the league in Hits (178) last season.

Washington Nationals Player Prop Facts

• Jacob Young has hit a home run in each of his last two appearances after not playing the previous day.
• Miles Mikolas has recorded four or more strikeouts in seven of his last eight road appearances against NL Central opponents.
• CJ Abrams has recorded at least one hit in each of his last 12 road appearances against NL Central opponents.

Matchup/League Facts

• The Cubs ranked 1st in the league for walks allowed last season (405).
• The Cubs ranked T3rd in the league for RBIs last season (771).
• The Nationals ranked 29th in the league for ERA last season (5.35).
• The Nationals ranked 29th in the league for opponent batting average last season (.268).

Nationals vs Cubs Prediction

The Nationals have won their last three meetings against the Cubs, all of them on the road. Over is 3-1 in their last 4 meetings.

In this Nationals vs Cubs Prediction, the Cubs are coming as -220 home favorites. The Cubs looked awful in opening day, giving up 10 total runs to the Nationals and I don’t think they will drop a second straight game in front of their home crowd. Horton has been excellent last season and his only start against the Nationals last season was a quality one, with just one earned run in 5.1 innings pitched. On the flip side, Mikolas has been torched by the Cubs last season, having given up 12 runs in 11 innings pitched as a member of the Cardinals, with his team losing 12-1 and 11-3 both games. Take the Cubs on the runline for a bounce-back win.