Nationals vs Orioles Prediction 4/22/25 MLB Picks Today

The Baltimore Orioles and Washington Nationals meet Tuesday in MLB action at Nationals Park. Here’s a Nationals vs Orioles Prediction. This article will include a Nationals vs Orioles Pick.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 9-12 on the year and play the Tigers, Yankees, and Royals next. The Baltimore Orioles are batting .232 on the season, have a .303 OBP, and a .418 slugging percentage. The Baltimore Orioles pitching staff has a 5.43 ERA and a 1.60 WHIP. Cedric Mullins leads the Baltimore Orioles with 19 hits and 19 RBI, while Adley Rutschman and Ryan O’Hearn have combined for 32 hits and 13 RBI.

Dean Kremer gets the ball for the Baltimore Orioles, and he is 2-2 with a 6.41 ERA and 13 strikeouts this season. Kremer is 3-0 with a 2.04 ERA and 10 strikeouts in his career against the Washington Nationals.

Washington Nationals Betting Preview

The Washington Nationals are 9-13 on the year and play the Mets, Phillies, and Reds next. The Washington Nationals are batting .229 on the season, have a .305 OBP, and a .368 slugging percentage. The Washington Nationals’ pitching staff has a 5.12 ERA and a 1.47 WHIP. Nathaniel Lowe leads the Washington Nationals with 23 hits and 17 RBI, while Keibert Ruiz and James Wood have combined for 41 hits and 28 RBI.

Mitchell Parker gets the ball for the Washington Nationals, and he is 2-1 with a 1.85 ERA and 16 strikeouts this season. This will be Parker’s second career game against the Baltimore Orioles.

Why the Washington Nationals will win

• The Orioles have lost each of their last seven night games against teams that held a losing record.
• The Nationals have won four of their last five games as home underdogs.
• The Orioles have failed to cover the run line in each of their last 17 Tuesday games as favorites against National League opponents.
• The Nationals have covered the run line in each of their last five games at Nationals Park.
• The Nationals have won the first inning in three of their last four night games at Nationals Park.
• The Nationals have led after 3 innings in each of their last six home games.
• The Orioles have trailed after 5 innings in each of their last seven night games against opponents that held a losing record.

Why the Baltimore Orioles will win

• The Nationals have lost 16 of their last 17 night games following a road loss.
• The Orioles have won each of their last four games at Nationals Park against NL East opponents that held a losing record.
• The Nationals have failed to cover the run line in each of their last five games against American League opponents.
• The Orioles have covered the run line in each of their last four games against NL East opponents.
• The Orioles have won the first inning in three of their last four road games against National League opponents.
• The Nationals have trailed after 3 innings in each of their last seven games against AL East opponents that held a losing record.
• The Nationals have trailed after 5 innings in each of their last seven games against AL East opponents that held a losing record.

Washington Nationals Player Prop Facts

• Jacob Young has recorded at least one Double in three of the Nationals’ last four night games against AL opponents that held a losing record.
• Josh Bell has hit a home run in three of his last four appearances against the Orioles.
• Jacob Young has scored at least one run in each of his last six home appearances against AL opponents that held a losing record.
• Josh Bell has recorded at least one RBI in six of his seven previous home appearances against AL East opponents that held a losing record.
• Josh Bell has recorded at least one Single in each of his last seven appearances with his team as an underdog against the Orioles.
• Nathaniel Lowe has recorded at least one hit in each of his last 11 home appearances after not playing the previous day.
• James Wood ranks T5th in the league in Home Runs (7) this season.

Baltimore Orioles Player Prop Facts

• Dean Kremer has recorded a win in four of his five previous road appearances against NL East opponents.
• Tyler O’Neill has recorded at least one Single in each of his last nine appearances against NL East opponents.
• Dean Kremer has recorded six or more strikeouts in three of his last four appearances with the Orioles as road favorites against NL opponents.
• Tyler O’Neill has scored at least one run in each of his last five appearances with his team as a favorite against NL East opponents.
• Ramon Laureano has recorded at least one hit in each of his last 15 appearances in night games against teams that held a losing record.
• Colton Cowser has recorded at least one RBI in each of the Orioles’ last four games as road favorites against NL East opponents.
• Ryan O’Hearn has hit a home run in each of his last two appearances in night games.
• Cedric Mullins ranks 5th amongst qualified players for On Base Percentage (.429) this season.

Nationals vs Orioles Prediction

The Orioles are the better team on paper, but that doesn’t mean much when they’ve underachieved up to this point. We also just saw the Orioles give up 24 runs to the Reds. Kremer hasn’t been great through 19.2 innings, allowing 25 hits and 14 earned runs. Parker is off to a great start through 24.1 innings, allowing 18 hits and five earned runs. If forced to pick a side between two struggling teams, I want the more favorable price and the better-in-form pitcher. That’s the Nationals at home. Give me the Nats.