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Nationals vs Phillies Prediction 9/16/26 MLB Picks Today

Philadelphia Phillies (83-68) vs. Washington Nationals (71-81)
September 16, 2026 6:45 pm EDT
The Line: Washington Nationals 157 / Philadelphia Phillies -191; Over/Under: 8.5
(Get latest betting odds)

The Philadelphia Phillies and Washington Nationals meet Wednesday in MLB action at Nationals Park. Here’s a Nationals vs. Phillies Prediction. This article will include a Nationals vs Phillies Pick.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 83-68 on the year and play the Mets and Brewers next. The Philadelphia Phillies are batting .242 on the season, with a .311 OBP and a .400 slugging percentage. The Philadelphia Phillies’ pitching staff has a 4.01 ERA and a 1.28 WHIP. Trea Turner leads the Philadelphia Phillies with 145 hits and 57 RBI, while Bryce Harper and Alec Bohm have combined for 275 hits and 166 RBI.


Zack Wheeler gets the ball for the Philadelphia Phillies, and he is 12-5 with a 3.14 ERA and 172 strikeouts this season. Wheeler is 14-15 with a 4.30 ERA and 208 strikeouts in his career against the Washington Nationals.

Washington Nationals Betting Preview

The Washington Nationals are 71-81 on the year and play the Tigers and Cardinals next. The Washington Nationals are batting .248 on the season, with a .324 OBP and a .427 slugging percentage. The Washington Nationals’ pitching staff has a 4.72 ERA and a 1.39 WHIP. CJ Abrams leads the Washington Nationals with 143 hits and 96 RBI, while James Wood and Daylen Lile have combined for 268 hits and 160 RBI.

Jared Simpson gets the ball for the Washington Nationals, and he is 1-0 with a 6.75 ERA and 4 strikeouts this season. This will be Simpson’s first career game against the Philadelphia Phillies.

Why the Washington Nationals will win

  • The home team has won each of the Nationals’ last 10 games.
  • The Phillies have lost each of their last three games as road favorites against NL East opponents.
  • The underdogs have covered the run line in nine of the Nationals’ last 10 games at Nationals Park.
  • The Phillies have failed to cover the run line in nine of their last 10 games as road favorites against NL opponents.
  • The Phillies have trailed after 3 innings in four of their last five games at Nationals Park.
  • The Phillies have lost the first inning in four of their last five games at Nationals Park.

Why the Philadelphia Phillies will win

  • The Nationals have lost seven of their last eight games against teams that held a winning record.
  • The Phillies have won six of their last seven games against the Nationals following a loss.
  • The Phillies have covered the run line in five of their last six road games against the Nationals following a loss.
  • The Nationals have failed to cover the run line in four of their last five games.
  • The Phillies have led after 3 innings in five of their last six road night games.
  • The Phillies have led after 5 innings in eight of their last nine Wednesday night games against the Nationals.

Total Runs Facts

  • Each of the Nationals’ last seven night games after playing the previous day have gone OVER the total runs line.
  • Seven of the Phillies’ last eight road games against NL East opponents have gone OVER the total runs line.
  • There has been at least one run scored in the first inning in each of the last seven games between the Phillies and Nationals.
  • There has been at least one run scored in the first inning in each of the Phillies’ last four games.

Washington Nationals Player Prop Facts

  • Brady House has recorded at least one hit in each of his last 12 appearances with the Nationals as home underdogs against NL opponents.
  • Andres Chaparro has hit a home run in each of the Nationals’ last two night games against opponents that held a winning record.
  • James Wood ranks 2nd amongst qualified players for On Base Percentage (.394) this season.

Philadelphia Phillies Player Prop Facts

  • Kyle Schwarber has hit a home run in each of the Phillies’ last four games as favorites against NL East opponents.
  • Zack Wheeler has recorded seven or more strikeouts in 16 of his last 19 appearances with the Phillies as favorites against NL East opponents.
  • Edmundo Sosa has recorded at least one hit in each of his last eight appearances with the Phillies as road favorites.
  • Zack Wheeler has recorded a win in four of his last five appearances against NL opponents that held a losing record.
  • Kyle Schwarber ranks 1st in the league in Home Runs (45) this season.

Matchup/League Facts

  • The Nationals rank 1st in the league for steals this season (166).
  • The Nationals rank 2nd in the league for slugging percentage this season (.427).
  • The Phillies rank 1st in the league for strikeouts this season (1468).
  • The Phillies are one of only three teams in the league to rank top 10 in both strikeouts and walks allowed this season.

Nationals vs Phillies Prediction

The Nationals continue to compete and are worth a look at the big plus money price. The problem is Simpson is a rookie with just four innings under his belt. Wheeler is having an All-Star year with a 3.14 ERA and 1.07 WHIP and averaging more than a strikeout per inning. Wheeler has allowed just 12 hits and 3 runs in his last 19 innings. The Phillies are fighting for playoff positioning, and these are games they can’t lose. Give me Philly on the road, and I’ll take the RL to shave down the price.

Randy Chambers's Free Pick: Philadelphia Phillies -1.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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