Nationals vs White Sox Prediction 4/26/26 MLB Picks Today

In this article, we will formulate a Nationals vs White Sox Prediction for this MLB matchup on Sunday, April 26^th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago White Sox Preview

The Chicago White Sox have a 11-16 record this season and are sitting in the fourth place of the AL Central. They have a 4-7 home record and are coming off a 3-6 home loss against the Nationals. Their previous three games were a 5-4 home win against the Nationals, a 4-1 road win and a 7-11 road loss against the Diamondbacks.

The White Sox have a .226 batting average this season, .319 OBP and .383 Slugging percentage. Chicago’s pitching staff has a 4.83 ERA and 1.48 WHIP. Chase Meidroth is the team’s best hitter with a .266 batting average. Munetaka Murakami leads the team in RBI with 20, also adding a team‑high 11 home runs.

Bryan Hudson (L) is the projected starting pitcher for the White Sox, and he has a 0-0 record, 1.54 ERA and 1.63 WHIP.

Washington Nationals Preview

The Washington Nationals have a 12-16 record this season and are sitting in the third place of the NL East. They have a 9-6 away record and are coming off a 6-3 road win against the White Sox. Their previous three games were a 4-5 road loss against the White Sox, a 2-7 and a 6-8 home loss against the Braves.

The Nationals have a .247 batting average this season, .331 OBP and .400 Slugging percentage. Washington’s pitching staff has a 5.44 ERA and 1.51 WHIP. Daylen Lile is the team’s best hitter with a .288 batting average. James Wood leads the team in RBI with 21, also adding a team‑high 10 home runs.

Foster Griffin (L) is the projected starting pitcher for the Nationals, and he has a 3-0 record, 3.38 ERA and 1.20 WHIP.

Washington Nationals @ the Chicago White Sox Betting Trends: April 26, 2026

• Probable Starting Pitcher: Bryan Hudson      Record this season: 0-0      ERA: 1.54
• Home Record: 0-0
• Last 5 against Nationals: 0-0

Why the Chicago White Sox will win

• The Nationals have lost each of their last five games following a win.
• The White Sox have won each of their last four home games against NL East opponents following a loss.
• The White Sox have covered the run line in each of their last eight games against National League opponents following a home loss.
• The Nationals have failed to cover the run line in each of their last five games following a win.
• The Nationals have trailed after 3 innings in 13 of their last 17 day games against American League opponents.
• The Nationals have trailed after 5 innings in five of their last six day games against American League opponents.

• Probable Starting Pitcher: Foster Griffin      Record this season: 3-0      ERA: 3.38
• Road Record: 2-0
• Last 5 against White Sox: –

Why the Washington Nationals will win

• The White Sox have lost seven of their last eight games as home favorites following an extra innings loss.
• The Nationals have won six of their last nine games as road underdogs.
• The White Sox have failed to cover the run line in each of their last nine games as favorites.
• The road team has covered the run line in 11 of the White Sox’s last 12 games.
• The White Sox have trailed after 3 innings in three of their last four games against opponents that held a losing record.
• The White Sox have trailed after 5 innings in each of their last five games against opponents that held a losing record.

Total Runs Facts

• Five of the Nationals’ last six games as underdogs against the White Sox have gone UNDER the total runs line.
• Five of the White Sox’s last six games as favorites against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the White Sox’s last 13 games as home favorites against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Nationals’ last five games at Rate Field.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit a home run in three of the White Sox’s last six games.
• Miguel Vargas has recorded at least one hit in each of the White Sox’s last six games.

Washington Nationals Player Prop Facts

• CJ Abrams has hit a home run in four of the Nationals’ last 11 day games.
• Keibert Ruiz has recorded at least one hit in each of his last eight Sunday appearances against teams that held a losing record.

Nationals vs White Sox Prediction

The White Sox are 5-2 in their last 7 meetings against the Nationals and are 3-1 in their last 4 meetings in Chicago.

In this Nationals vs White Sox Prediction, the White Sox are coming as -130 home favorites. Foster Griffin has been struggling for the Nats, as he has given up 7 runs in his last two starts and Washington is 1-3 in its last 4 games. On the flip side, the White Sox are better against lefties and are 4-2 in their last 6 games, with the Nationals being weaker against left-handed pitching, so this sets up as a White Sox spot. Take the White Sox on the moneyline at home for the bounce-back win.