Orioles vs Astros Prediction 8/22/25 MLB Picks Today

The Houston Astros and Baltimore Orioles meet Friday in MLB action at Oriole Park at Camden Yards. Here’s a Orioles vs Astros Prediction. This article will include a Orioles vs Astros Pick.

Houston Astros Betting Preview

The Houston Astros are 70-58 on the year and play the Rockies, Angels, and Yankees next. The Houston Astros are batting .253 on the season, have a .318 OBP, and a .399 slugging percentage. The Houston Astros pitching staff has a 3.87 ERA and a 1.22 WHIP. Jose Altuve leads the Houston Astros with 130 hits and 64 RBI, while Jeremy Pena and Yainer Diaz have combined for 228 hits and 100 RBI.

Lance McCullers Jr. gets the ball for the Houston Astros, and he is 2-4 with a 6.90 ERA and 50 strikeouts this season. McCullers is 3-0 with a 2.90 ERA and 37 strikeouts in his career against the Baltimore Orioles.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 59-68 on the year and play the Red Sox, Giants, and Padres next. The Baltimore Orioles are batting .240 on the season, have a .305 OBP, and a .403 slugging percentage. The Baltimore Orioles pitching staff has a 4.66 ERA and a 1.38 WHIP. Gunnar Henderson leads the Baltimore Orioles with 126 hits and 57 RBI while Jackson Holliday and Jordan Westburg have combined for 195 hits and 94 RBI.

Cade Povich gets the ball for the Baltimore Orioles, and he is 2-6 with a 4.98 ERA and 90 strikeouts this season. Povich is 0-0 with a 7.20 ERA and 13 strikeouts in his career against the Houston Astros.

Why the Baltimore Orioles will win

• The Orioles have won each of their last eight Friday home games against American League opponents.
• The Astros have lost 10 of their last 11 games against American League opponents following a win.
• The Astros have failed to cover the run line in 17 of their last 18 games against American League opponents that held a losing record.
• The Orioles have covered the run line in each of their last seven games after playing the previous day.
• The Astros have trailed after 5 innings in seven of their last nine games against American League opponents that held a losing record.
• The Orioles have led after 3 innings in each of their last five Friday night games as home favorites.

Why the Houston Astros will win

• The Astros have won eight of their last nine games as underdogs against the Orioles.
• The Orioles have lost four of their last five games as favorites.
• The underdogs have covered the run line in each of the Orioles’ last 13 games.
• The Orioles have failed to cover the run line in each of their last five games as home favorites against AL West opponents.
• The Astros have led after 3 innings in six of their last seven games at Oriole Park at Camden Yards against AL East opponents that held a losing record.
• The Astros have won the first inning in each of their last four games as road underdogs against AL East opponents.
• The Astros have led after 5 innings in five of their last six night games against opponents that held a losing record.

Baltimore Orioles Player Prop Facts

• Tyler O’Neill has hit a home run in four of his last five appearances with the Orioles as favorites.
• Gary Sanchez has recorded at least one hit in each of his last 10 appearances with his team as a favorite against AL West opponents.
• Gunnar Henderson has recorded a Double in four of the Orioles’ last five games against AL West opponents at Oriole Park at Camden Yards.

Houston Astros Player Prop Facts

• Yainer Diaz has hit a home run in each of the Astros’ last two road games against the Orioles.
• Lance McCullers Jr. has recorded five or more strikeouts in each of his last eight appearances in night games against AL teams that held a losing record.
• Christian Walker has recorded at least one Double in three of the Astros’ last four games as underdogs against AL East opponents.
• Jake Meyers has recorded at least one hit in each of his last 16 road appearances against AL opponents.
• Jeremy Pena ranks 3rd amongst qualified players for Batting Average (.306) this season.

Orioles vs Astros Prediction

The Astros are the safer bet given they’re the better team, but I’m not getting behind McCullers, who has struggled all season and hasn’t pitched in over a month due to a finger injury. Povich hasn’t been much better with a 4.98 ERA and 1.44 WHIP, and he has a 6.05 ERA and .287 allowed batting average in 41.2 home innings. The Astros also just faced Povich, so there’s going to be some familiarity with the quick turnaround. I expect some runs in this spot. Give me the over.