Orioles vs Cardinals Prediction 5/26/25 MLB Picks Today

The St. Louis Cardinals and the Baltimore Orioles meet Monday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Orioles vs Cardinals Prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Erick Fedde for the start here, and Fedde is 3-3 with a 3.77 ERA and 34 strikeouts this season. In his career, Fedde is 1-0 with a 0.49 ERA and 12 strikeouts against Baltimore. The Baltimore Orioles will send out Charlie Morton here, and Morton is 0-7 with a 7.68 ERA and 40 strikeouts this season. In his last five starts against the Cardinals, Morton is 2-1 with a 4.15 ERA and 17 strikeouts.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to build on their 4-3 win over Arizona last time out to improve to 30-23 on the year. After this series, the Cardinals will head on the road for a series against the Texas Rangers.

Cardinals Win Three In A Row

Brendan Donovan has a team-high 65 hits along with 17 doubles, 3 home runs, and 22 RBIs, while Lars Nootbaar has 49 hits with 7 home runs, 25 RBIs, and 4 stolen bases. Nolan Arenado also has 44 hits with 10 doubles, 5 home runs, and 25 RBIs of his own, and Victor Scott II has 44 hits with 8 doubles, a triple, 8 RBIs, and a team-high 15 stolen bases. Willson Contreras has also chipped in 46 hits with 6 home runs and 28 RBIs of his own this season.

Why the St. Louis Cardinals will win

• The Orioles have lost each of their last nine games against National League opponents following a win.
• The Cardinals have won each of their last six games against teams that held a losing record.
• The Orioles have failed to cover the run line in each of their last eight games at Oriole Park at Camden Yards.
• The Cardinals have covered the run line each of their last six games against teams that held a losing record.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in each of his last two road appearances.
• Masyn Winn has recorded a Double in each of the Cardinals’ last three games against the Orioles.
• Willson Contreras has recorded at least one RBI in six of his last seven road appearances against AL opponents that held a losing record.
• Willson Contreras has scored a run in each of his four previous appearances at Oriole Park at Camden Yards against AL East opponents that held a losing record.
• Nolan Arenado has recorded at least one Single in 12 of the Cardinals’ last 13 games against AL East opponents.
• Erick Fedde has recorded four or more strikeouts in three of his last four appearances against opponents that held a losing record.
• Willson Contreras has recorded at least one hit in each of his seven previous appearances at Oriole Park at Camden Yards.
• Brendan Donovan ranks T4th in the league in Hits (65) this season.

Baltimore Orioles Recap

The Baltimore Orioles come into this game looking to build on their 5-1 win over the Boston Red Sox from Sunday’s matchup to improve to 18-34 on the year. After this series, the Orioles will take on the Chicago White Sox at home.

Orioles Win Back-To-Back Games

Cedric Mullins has 40 hits so far this season as well as 9 doubles, 10 home runs, and 31 RBIs with 7 stolen bases and a .226 batting average, while Adley Rutschman has 37 hits with 7 doubles, 5 homers, and 15 RBIs. Ryan Mountcastle has 39 hits with 10 doubles, and Jackson Holliday has 44 hits with 5 doubles, 2 triples, 6 homers, and 22 RBIs. Ryan Mountcastle has 39 hits with 10 doubles, 2 homers, and 15 RBIs, and Gunnar Henderson has a team-high 56 strikeouts as well this season. Ryan O’Hearn also chipped in 49 hits with 7 doubles and 8 home runs with 18 RBIs, and Heston Kjerstad added 4 homers and 15 RBIs.

Why the Baltimore Orioles will win

• The Cardinals have lost each of their last eight day games against AL East opponents that held a losing record.
• The home team has won each of the Cardinals’ last three games.
• The Cardinals have failed to cover the run line in six of their last seven day games following a home win.
• The Orioles have covered the run line in four of their last five day games against National League opponents that held a winning record.

Baltimore Orioles Player Prop Facts

• Ryan O’Hearn has hit a home run in each of the Orioles’ last two games against NL Central opponents that held a winning record.
• Ramon Urias has recorded at least one RBI in four of his last five appearances in day games.
• Ramon Urias has recorded a Single in each of his last seven home appearances against NL opponents that held a winning record.
• Charlie Morton has recorded five or more strikeouts in each of his last eight Monday appearances in day games.
• Colton Cowser has recorded at least one hit in each of the Orioles’ last 10 games against NL opponents that held a winning record.
• Colton Cowser has scored at least one run in each of the Orioles’ last four day games against NL opponents that held a winning record.
• Ryan O’Hearn ranks 5th amongst qualified players for Batting Average (.329) this season.

Total Runs Facts

• Eight of the Orioles’ last nine home games against National League opponents have gone OVER the total runs line.
• Seven of the Cardinals’ last eight road games after playing the previous day have gone UNDER the total runs line.

Orioles vs Cardinals Prediction

I’m on St. Louis here. I haven’t been able to get myself to bet Erick Fedde often this season, but the thing is, it beats the alternative right now, which is backing the Orioles with Charlie Morton pitching. This is easily the worst season of Morton’s career, but it doesn’t look like it’s going to get any better anytime soon. Until Morton gives us a reason to think it will, I have to keep fading him. Give me the Cardinals.