Orioles vs Guardians Prediction 4/16/25 MLB Picks Today

The Cleveland Guardians and the Baltimore Orioles meet Wednesday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Orioles vs Guardians Prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Gavin Williams for the start here, and Williams is 1-0 with a 3.46 ERA and 14 strikeouts this season. This will be Williams’ second career start against the Orioles. Baltimore will send out Dean Kremer for the start here, and Kremer is 1-2 with an 8.16 ERA and 11 strikeouts this season. In his career, Kremer is 0-3 with a 6.50 ERA and 10 strikeouts against the Guardians.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to build on their series-opening 6-3 win on Tuesday to improve to 9-7 on the year. After this series, the Guardians will head on the road once again for an interleague series with the Pittsburgh Pirates.

Guardians Win 6 Of Their Last 7

Steven Kwan leads the Guardians with 21 hits as part of a .333 batting average and 3 home runs, a double, and 11 RBIs. Kyle Manzardo has 9 hits with a double, a triple, 4 home runs, and a team-high 11 RBIs as well this year. Nolan Jones has a team-high 3 doubles while Brayan Rocchio, Jose Ramirez, and Carlos Santana all have a pair of doubles, while Jones, Manzardo, and Gabriel Arias all share the team-high with 16 strikeouts so far this season.

Why the Cleveland Guardians will win

• The Orioles have lost each of their last six games as favorites against AL Central opponents.
• The Guardians have won each of their last five night games against teams that held a losing record.
• The Guardians have covered the run line each of their last seven road games against teams that held a losing record.
• The Orioles have failed to cover the run line each of their last seven home games against teams that held a winning record.

Cleveland Guardians Player Prop Facts

• Steven Kwan has hit a home run in each of the Guardians’ last two road games against opponents that held a losing record.
• Steven Kwan has recorded at least one RBI in each of the Guardians’ last four games as road underdogs against AL opponents.
• Steven Kwan has scored at least one run in seven of the Guardians’ last eight games against the Orioles.
• Steven Kwan has recorded at least one Single in 13 of the Guardians’ last 14 road games against AL opponents.
• Steven Kwan has recorded at least one hit in each of the Guardians’ last 14 road games against AL opponents.
• Steven Kwan ranks T9th amongst qualified players for Batting Average (.333) this season.

Baltimore Orioles Recap

The Baltimore Orioles come into this one looking to rebound after starting the series on the wrong foot, falling to 6-10 on the year as a result. After this series, the Orioles will welcome the Cincinnati Reds to town for an interleague set.

Orioles Trying To Avoid Another Series Loss

Cedric Mullins has a team-high 15 hits so far this season as well as team-highs of 4 doubles, 4 home runs, and 17 RBIs with 3 stolen bases and a .300 batting average, while Adley Rutschman has 14 hits with a pair of doubles, 3 homers, and 6 RBIs. Ryan Mountcastle has 14 hits with 3 doubles, and Tyler O’Neill has 13 hits with 3 doubles, a triple, and 2 homers with 8 RBIs. Jordan Westburg added 3 home runs but also has a team-high 14 strikeouts, as does Gunnar Henderson.

Why the Baltimore Orioles will win

• The Guardians have lost each of their last five road games following a win.
• The Orioles have won four of their last five night games against AL Central opponents that held a winning record.
• The Guardians have failed to cover the run line in each of their last eight Wednesday night games against American League opponents.
• The favorites have covered the run line in four of the Guardians’ last five games.

Baltimore Orioles Player Prop Facts

• Cedric Mullins has hit a home run in three of the Orioles’ last four home games against AL Central opponents.
• Gunnar Henderson has scored at least one run in seven of the Orioles’ last eight games as favorites against the Guardians.
• Adley Rutschman has recorded a Single in seven of his last eight appearances after playing the previous day.
• Dean Kremer has recorded five or more strikeouts in each of his last 10 appearances with the Orioles as home favorites against AL opponents.
• Gary Sanchez has recorded an RBI in each of his last four appearances against AL opponents that held a winning record.
• Jorge Mateo has recorded a Double in four of his last five appearances against the Guardians.
• Ramon Urias has recorded at least one hit in each of his last 10 home appearances.
• Cedric Mullins ranks 7th amongst qualified players for On Base Percentage (.435) this season.

Total Runs Facts

• Each of the Orioles’ last six games as favorites against American League opponents have gone OVER the total runs line.
• Each of the Guardians’ last four games as underdogs against the Orioles have gone OVER the total runs line.

Orioles vs Guardians Prediction

I’m on the Guardians in this one. I just think that the Orioles’ struggles right now can probably be linked to starting a lot of high-risk pitchers like Charlie Morton and Dean Kremer. The offense hasn’t been consistent enough in the early going to counteract when those starters have off days on the bump. Both bullpens are solid, but for me, the Guardians have been the more disciplined team at the plate for a while, and I think they have the potential to make Kremer pay here. I’ll back the Guardians on the road in this one.