Orioles vs Guardians Prediction 4/17/25 MLB Picks Today

The Cleveland Guardians and the Baltimore Orioles meet Thursday in MLB action from Camden Yards. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Orioles vs Guardians Prediction.

Starting Pitching Matchup

The Cleveland Guardians will send out Tanner Bibee for the start here and Bibee is 1-1 with a 4.40 ERA and 10 strikeouts this season. This will be Bibee’s second career start against the Orioles. Tomoyuki Sugano will get the nod for the Orioles here and is 1-1 with a 3.86 ERA and 5 strikeouts this season. This will be Sugano’s first career start against the Guardians.

Cleveland Guardians Recap

The Cleveland Guardians will be out to rebound after taking one on the chin in a 9-1 loss in Wednesday’s matchup. After this series, the Guardians will head on the road once again for an interleague series with the Pittsburgh Pirates.

Guardians Looking To Win Rubber Match

Steven Kwan leads the Guardians with 21 hits as part of a .333 batting average and 3 home runs, a double and 11 RBIs. Kyle Manzardo has 9 hits with a double, a triple, 4 home runs and a team-high 11 RBIs as well this year. Nolan Jones has a team-high 3 doubles while Brayan Rocchio, Jose Ramirez and Carlos Santana all have a pair of doubles, while Jones, Manzardo and Gabriel Arias all share the team-high with 16 strikeouts so far this season.

Why the Cleveland Guardians will win

• The Orioles have lost each of their last seven games following a win.
• The Guardians have won each of their last six games against the Orioles following a road loss.
• The Orioles have failed to cover the run line in each of their last seven games following a win.
• The Guardians have covered the run line in seven of their last eight road games against teams that held a losing record.

Cleveland Guardians Player Prop Facts

• Steven Kwan has hit a home run in two of the Guardians’ last three road games against opponents that held a losing record.
• Jose Ramirez has recorded at least one hit in each of the Guardians’ last 13 games as favorites against AL East opponents.
• Jose Ramirez has recorded at least one RBI in three of the Guardians’ last four games as favorites against the Orioles.
• Steven Kwan has recorded at least one Single in each of the Guardians’ last 10 games as road favorites against AL opponents.
• Jose Ramirez has scored at least one run in each of the Guardians’ last four games as favorites against the Orioles.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.

Baltimore Orioles Recap

The Baltimore Orioles will try to win the series after evening the set up at one win apiece thanks to their beatdown win over the Guardians on Wednesday. After this series, the Orioles will welcome the Cincinnati Reds to town for an interleague series.

Orioles Trying To String Wins Together

Cedric Mullins has a team-high 15 hits so far this season as well as team-highs of 4 doubles, 4 home runs and 17 RBIs with 3 stolen bases and a .300 batting average while Adley Rutschman has 14 hits with a pair of doubles, 3 homers and 6 RBIs. Ryan Mountcasle has 14 hits with 3 doubles and Tyler O’Neill has 13 hits with 3 doubles, a triple and 2 homers with 8 RBIs. Jordan Westburg’s added 3 home runs but also has a team-high 14 strikeouts as does Gunnar Henderson.

Why the Baltimore Orioles will win

• The Guardians have lost each of their last six road games after playing the previous day.
• The Orioles have won four of their last five games as underdogs against AL Central opponents.
• The Orioles have covered the run line in each of their last 12 Thursday games as home underdogs.
• The Guardians have failed to cover the run line in each of their last six road games after playing the previous day.

Baltimore Orioles Player Prop Facts

• Ryan O’Hearn has hit a home run in three of the Orioles’ last four night games against opponents that held a winning record.
• Adley Rutschman has scored a run in each of the Orioles’ last five games as home underdogs against AL Central opponents.
• Ryan O’Hearn has recorded at least one Single in each of his last six appearances with the Orioles as underdogs against AL opponents.
• Cedric Mullins has recorded at least one hit in each of his last 11 home appearances against AL Central opponents.
• Jorge Mateo has recorded a Double in four of his last five appearances against the Guardians.
• Gary Sanchez has recorded an RBI in each of his last four appearances against AL opponents that held a winning record.

Total Runs Facts

• Each of the Orioles’ last six night games against AL Central opponents have gone OVER the total runs line.
• Each of the Guardians’ last four night games against American League opponents have gone OVER the total runs line.

Orioles vs Guardians Prediction

I’m on the Guardians here. The Orioles definitely showed some signs of life offensively in Wednesday’s win, but the pitching staff was lucky to get themselves out of some serious jams at certain points of that game. It was a few timely hits that the Orioles had that won them the game. Maybe it’s a sign that Baltimore’s starting to turn things around, but I need more than one game to really buy what they’re selling. Bibee is supposed to be the Guardians’ staff ace, and Sugano has not drummed up many strikeouts this season, which is a concern against a patient and consistent Guardians’ lineup that’s been hitting righties well as of late. I’ll side with the Guardians to rebound and win the series finale on Thursday.