Orioles vs Pirates Prediction 9/10/25 MLB Picks Today

The Pittsburgh Pirates and Baltimore Orioles meet Wednesday in MLB action at Oriole Park at Camden Yards. Here’s a Orioles vs Pirates Prediction. This article will include a Orioles vs Pirates Pick.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 64-81 on the year and play the Nationals, Cubs, and Athletics next. The Pittsburgh Pirates are batting .232 on the season, have a .306 OBP, and a .350 slugging percentage. The Pittsburgh Pirates pitching staff has a 3.89 ERA and a 1.23 WHIP. Bryan Reynolds leads the Pittsburgh Pirates with 130 hits and 70 RBI, while Andrew McCutchen and Tommy Pham have combined for 197 hits and 103 RBI.

Paul Skenes gets the ball for the Pittsburgh Pirates, and he is 10-9 with a 1.98 ERA and 195 strikeouts this season. This will be Skenes’ first career game against the Baltimore Orioles.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 67-77 on the year and play the Blue Jays, White Sox, and Yankees next. The Baltimore Orioles are batting .240 on the season, have a .307 OBP, and a .402 slugging percentage. The Baltimore Orioles pitching staff has a 4.63 ERA and a 1.37 WHIP. Gunnar Henderson leads the Baltimore Orioles with 139 hits and 61 RBI while Jackson Holliday and Jordan Westburg have combined for 210 hits and 87 RBI.

Tyler Wells gets the ball for the Baltimore Orioles, and he is 1-0 with a 3.60 ERA and 4 strikeouts this season. Wells is 1-0 with a 2.19 ERA and 11 strikeouts in his career against the Pittsburgh Pirates.

Pittsburgh Pirates @ Baltimore Orioles Betting Trends: September 10, 2025

• Probable Starting Pitcher: Tyler Wells      Record this season: 1-0      ERA: 3.60
• Home Record: 0-0
• Last 5 against Pirates: 1-0

Why the Baltimore Orioles will win

• The Pirates have lost each of their last nine night games against American League opponents that held a losing record.
• The Orioles have won five of their last six games as underdogs.
• The Orioles have covered the run line in eight of their last nine games as home underdogs following a win.
• The Pirates have failed to cover the run line in four of their last five games as road favorites after playing the previous day.
• The Orioles have led after 3 innings in three of their last four home games against National League opponents that held a losing record.
• The Pirates have trailed after 5 innings in seven of their last eight Wednesday night games against American League opponents that held a losing record.

• Probable Starting Pitcher: Paul Skenes      Record this season: 10-9      ERA: 1.98
• Road Record: 4-5
• Last 5 against Orioles: –

Why the Pittsburgh Pirates will win

• The Orioles have lost nine of their last 10 night games against NL Central opponents.
• The Pirates have won each of their last four games following a road loss.
• The Orioles have failed to cover the run line each of their last eight home games against NL Central opponents that held a losing record.
• The Pirates have covered the run line in each of their last eight games after playing the previous day following an extra innings loss.
• The Orioles have trailed after 3 innings in seven of their last eight games as underdogs against NL Central opponents.
• The Pirates have won the first inning in each of their last three games as favorites against the Orioles.
• The Orioles have trailed after 5 innings in nine of their last 10 night games against NL Central opponents that held a losing record.

Total Runs Facts

• Each of the Orioles’ last nine home games have gone UNDER the total runs line.
• Twelve of the Pirates’ last 14 games as favorites against AL East opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Orioles’ last six Wednesday games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 10 of the Pirates’ last 12 games as favorites against American League opponents.

Baltimore Orioles Player Prop Facts

• Tyler O’Neill has hit a home run in each of his last three home appearances against NL opponents.
• Adley Rutschman has recorded a Double in four of his last five appearances against NL Central opponents.
• Adley Rutschman has recorded at least one hit in each of his last seven appearances with the Orioles as underdogs against NL opponents.

Pittsburgh Pirates Player Prop Facts

• Jared Triolo has hit a home run in each of the Pirates’ last two games as favorites.
• Tommy Pham has recorded at least one hit in each of his last 10 appearances against AL opponents.
• Andrew McCutchen has recorded a Double in three of his last four appearances with the Pirates as road favorites against AL opponents.
• Paul Skenes ranks 1st amongst qualified players for Earned Run Average (1.98) this season.

Matchup/League Facts

• The Orioles rank 28th in the league for opponent batting average this season (.261).
• The Orioles rank 27th in the league for home runs allowed this season (195).
• The Pirates rank 30th in the league for runs scored this season (524).
• The Pirates rank 30th in the league for home runs this season (103).

Orioles vs Pirates Prediction

The Orioles are playing the better ball this week, but they’re throwing out Wells, who has just 5 innings under his belt this season. Not ideal. The Pirates aren’t winning, but it’s tough to bet against a pitcher in Skenes who has a 1.98 ERA and 0.94 WHIP. In his last 40 innings, Skenes has allowed 35 hits and 11 earned runs. In his last 19 innings, Skenes has allowed 1 earned run. Two teams going nowhere, but I’m going to side with arguably the best arm in the sport, especially at this reasonable price. Give me the Pirates.