Orioles vs Rays Prediction 9/23/25 MLB Picks Today

The Baltimore Orioles and Tampa Bay Rays meet on Wednesday in MLB action from Oriole Park at Camden Yards.. Here’s an Orioles vs Rays prediction. We will look at this from a betting perspective and determine the best Orioles vs Rays pick.

Rays Offense Has to Be Better

The Rays offense has to be better after they were shutout on Tuesday. The Rays finished the game with only two hits total, and zero runs crossed the plate. Ryan Pepiot was on the mound and wasn’t good enough going three innings giving up three hits and three runs. Ian Seymour came out of the bullpen and had issues also giving up four hits and three runs in four innings on the mound. 

The Rays are averaging 4.46 runs while their pitching is giving up 4.147 runs per game. The offense is ranked 15th while the pitching is ranked 10th. Junior Caminero has hit 44 home runs and driven in 108 RBIs so far this season. Getting the start for the Rays will be Shane Baz who sits with a 10-12 record and an ERA of 4.99. Against the Toronto Blue Jays in his last start, he went five innings giving up two hits and zero runs. 

Why the Rays Will Beat the Orioles

• The underdogs have won five of the Rays’ last six games at Oriole Park at Camden Yards.
• The Orioles have lost five of their last six games as home favorites against AL East opponents following a win.
• The Orioles have failed to cover the run line in each of their last seven games as home favorites against American League opponents.
• The Rays have covered the run line in 10 of their last 11 night games against AL East opponents following a road loss.
• The Rays have led after 5 innings in five of their last six games as underdogs against American League opponents.

Can Orioles pitching be Strong Again? 

The Orioles pitching was sure impressive on Tuesday, and they will look to build on that here again. Dean Kremer was dominant and he went 6.1 innings giving up one hit and zero runs. He had four strikeouts and zero walks. Gunnar Henderson was the top offensive player, finishing with a hit and two RBIs. 

The Orioles are averaging 4.21 runs while their pitching is giving up 4.87 runs per game. The offense is ranked 24th in the league while the pitching is also ranked 24th. Gunnar Henderson has hit 16 home runs and driven in 65 RBIs so far this season. Getting the start for the Orioles will be Tyler Wells who sits with a 2-0 record and an ERA of 2.04. Against the White Sox in his last start he went six innings giving up four hits and one run.

Why the Orioles Will Beat the Rays

• The Orioles have won eight of their last nine games against teams that held a losing record.
• The Rays have lost each of their last four road games against AL East opponents.
• The Rays have failed to cover the run line in each of their last six road games against American League opponents.
• The Orioles have covered the run line each of their last four games against American League opponents that held a losing record.
• The Orioles have won the first inning in three of their last four home games against American League opponents that held a losing record.
• The Orioles have led after 5 innings in five of their last six games as home favorites against AL East opponents.
• The Rays have trailed after 3 innings in four of their last five games against opponents that held a losing record.

Orioles vs Rays Prediction 

The Orioles and Rays are both going to really struggle to get the offense going in this game. Wells has been really impressive this season and in his last start, he gave up only one run. Baz in his last start against the Toronto Blue Jays was also impressive giving up only two hits and zero runs. The Orioles offense has been very inconsistent and they are going to really struggle to get that offense going here. Neither team is reaching three runs, and this game is going to stay under the total.