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Orioles vs Red Sox Prediction 4/24/26 MLB Picks Today

Boston Red Sox (9-16) vs. Baltimore Orioles (12-13)
April 24, 2026 7:05 pm EDT
The Line: Baltimore Orioles -118 / Boston Red Sox -102; Over/Under: 9
(Get latest betting odds)

In this article we will formulate an Orioles vs Red Sox prediction for this MLB game on Friday, April 24th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 12-13 this season after they won two out of three against the Royals by scores of 7-5, 5-6, and 8-6. In game three, Baltimore trailed 3-2 in the sixth inning, but they scored six runs in the sixth for the win. The Orioles recorded 11 hits and they committed one error in the game, while they were led by Mayo, who went 1-4 with one home run and three RBIs. Bassitt allowed eight hits and five earned runs over 5.1 innings for the win, while Cano allowed one earned run in relief. Prior to that series, Baltimore lost three out of four against the Guardians and two out of three against the Diamondbacks. 

This season, Baltimore has a 4.00 ERA with a 1.36 WHIP and a .251 opponent batting average, while they have scored 111 runs with a .230 batting average and a .320 on base percentage. Gunnar Henderson has led the Orioles with seven home runs and 15 RBIs, while Jeremiah Jackson has added five home runs and 19 RBIs. The projected starting pitcher for Baltimore is Brandon Young, who is 1-0 with a 0.00 ERA and a 0.80 WHIP over 5.0 innings pitched this season. 

Boston Red Sox Betting Preview

The Boston Red Sox are 9-16 this year after they lost all three games against the Yankees by scores of 0-4, 1-4, and 2-4. In game three, Boston led 2-1 in the fifth inning, but they allowed three runs in the seventh for the loss. The Red Sox recorded four hits and they committed one error, while they were led by Mayer and Narvaez, who both had one RBI in the game. Tolle allowed three hits and one earned run over 6.0 innings, while Coulombe picked up the loss in relief. Prior to that series, Boston split four games with the Tigers and lost two out of three against the Twins before that. 

This season, Boston has a 4.37 ERA with a 1.33 WHIP and a .243 opponent batting average, while they have scored 92 runs with a .223 batting average and a .305 on base percentage. Wilson Contreras has led the Red Sox with four home runs and 12 RBIs, while Trevor Story has added two home runs and 17 RBIs. The projected starting pitcher for Boston is Brayan Bello, who is 1-2 with a 6.75 ERA and a 1.93 WHIP over 18.2 innings pitched this year. 

Why the Baltimore Orioles will win

  • The Red Sox have lost each of their last eight games as underdogs after playing the previous day.
  • The Orioles have won five of their last six games against American League opponents that held a losing record.
  • The Red Sox have failed to cover the run line in each of their last nine night games against American League opponents.
  • The Orioles have covered the run line in seven of their last eight games against the Red Sox.
  • The Red Sox have lost the first inning in each of their last six road games against American League opponents.
  • The Red Sox have trailed after 3 innings in five of their last six road night games.
  • The Red Sox have trailed after 5 innings in eight of their last nine road games against American League opponents.

Why the Boston Red Sox will win

  • The road team has won each of the last eight games between the Red Sox and Orioles.
  • The Orioles have lost each of their last five games as home favorites against American League opponents following a win.
  • The Orioles have failed to cover the run line in each of their last seven games as home favorites against American League opponents following a win.
  • The underdogs have covered the run line in eight of the last nine games between the Red Sox and Orioles.
  • The Red Sox have won the first inning in four of their last five games at Oriole Park at Camden Yards.
  • The Orioles have trailed after 3 innings in each of their last five games against AL East opponents.
  • The Orioles have trailed after 5 innings in four of their last five games.

Total Runs Facts

  • Each of the Red Sox’s last seven games against AL East opponents have gone UNDER the total runs line.
  • Seven of the last eight games between the Red Sox and Orioles have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last six road games against American League opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Orioles’ last 10 games as home favorites against AL East opponents.

Baltimore Orioles Player Prop Facts

  • Gunnar Henderson has hit a home run in four of his last five appearances with the Orioles as home favorites against the Red Sox.
  • Taylor Ward has recorded at least one hit in each of the Orioles’ last seven games as favorites against AL opponents.

Boston Red Sox Player Prop Facts

  • Roman Anthony has hit a home run in three of his last four appearances in night games against teams that held a losing record.
  • Roman Anthony has recorded at least one hit in each of his last 11 road appearances against opponents that held a losing record.

Matchup/League Facts

  • The Orioles rank T25th in the league for strikeouts against this season (236).
  • The Orioles rank 7th in the league for doubles this season (45).
  • The Red Sox rank 30th in the league for slugging percentage this season (.331).
  • The Red Sox rank T29th in the league for home runs this season (14).

Orioles vs Red Sox Prediction 

Boston comes into this matchup looking to bounce back from a rough series with the Yankees, but they have scored two runs or fewer in four of their last five games. The Red Sox are 4-8 on the road this year, while the Orioles are 6-6 at home. Baltimore is coming off of a series win against KC, but they have allowed 5+ runs in four straight. Bello hasn’t been very reliable to start the season for Boston, so I will take the Orioles here. 

David Racey's Free Pick: Orioles ML

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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