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Orioles vs Red Sox Prediction 8/26/25 MLB Picks Today

Boston Red Sox (72-60) vs. Baltimore Orioles (60-71)
August 26, 2025 6:35 pm EDT
The Line: Baltimore Orioles -105 / Boston Red Sox -115; Over/Under: 9.5
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In this article we will formulate an Orioles vs Red Sox prediction for this MLB game on Tuesday, August 26th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 60-71 this season after they lost game one by a score of 4-3 on Monday night. Baltimore took a 3-1 lead in the third inning, but they failed to score in the last six innings for the loss. The Orioles recorded six hits and they committed one error in the game, while they were led by Cowser, who went 3-4 with one home run and three RBIs in the loss. Baltimore started Sugano, who allowed six hits and four earned runs over 6.0 innings for the loss, while Wolfram and Martin combined for 3.0 scoreless innings in relief. 

Prior to this series, the Orioles lost three out of four against the Astros, but did win both games against the Red Sox before that. Baltimore has lost four of their last five games and they are currently last in the AL East standings. The Baltimore pitching staff has a 4.69 ERA with a 1.38 WHIP and a .261 opponent batting average, while their offense has scored 570 runs with a .241 batting average and a .307 on base percentage this season. Jackson Holliday has led Baltimore with 15 home runs and 49 RBIs, while Gunnar Henderson has added 16 home runs and 59 RBIs this year. The projected starting pitcher for Baltimore is Kyle Bradish, who is 8-2 with a 3.72 ERA and a 1.27 WHIP over 111.1 innings pitched this season. 

Boston Red Sox Betting Preview

The Boston Red Sox are 72-60 this year after they won game one to start this series on Monday night. Boston led 1-0 in the first inning, but they needed three runs in the fifth to escape with the victory. The Red Sox recorded seven hits and they committed one error in the game, while they were led by Duran, who went 1-3 with one home run and three RBIs in the win. Boston started Bernardino, who was the opener, while Fitts allowed three earned runs over 4.0 innings and picked up the win. 

Prior to this series, the Red Sox won three out of four against the Yankees, but did lose both games against the Orioles before that. Boston has won four of their last five games and they are currently second in the AL East standings. The Boston pitching staff has a 3.72 ERA with a 1.29 WHIP and a .243 opponent batting average, while their offense has scored 657 runs with a .252 batting average and a .325 on base percentage this season. Wilyer Abreu (IL) has led Boston with 22 home runs and 69 RBIs, while Trevor Story has added 20 home runs and 82 RBIs this year. The projected starting pitcher for Boston is Lucas Giolito, who is 8-2 with a 3.72 ERA and a 1.27 WHIP over 111.1 innings pitched this year. 

Why the Red Sox will beat the Orioles

  • The road team has won seven of the Orioles’ last eight games.
  • The Orioles have lost eight of their last nine night games against American League opponents following a loss.
  • The road team has covered the run line in nine of the Orioles’ last 10 games.
  • The Orioles have failed to cover the run line in four of their last five games against teams that held a winning record.
  • The Orioles have trailed after 3 innings in four of their last five night games against opponents that held a winning record.
  • The Red Sox have won the first inning in three of their last four road games against AL East opponents that held a losing record.
  • The Red Sox have led after 5 innings in each of their last seven road games against opponents that held a losing record.

Total Runs Facts

  • Five of the Orioles’ last six games as home underdogs have gone UNDER the total runs line.
  • Nine of the Red Sox’s last 11 games as favorites against American League opponents have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Orioles’ last nine games as underdogs.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Red Sox’s last nine games against AL East opponents.

Baltimore Orioles Player Prop Facts

  • Gunnar Henderson has recorded a Double in five of the Orioles’ last six games as home underdogs against AL opponents.
  • Colton Cowser has hit a home run in each of the Orioles’ last three night games against opponents that held a winning record.
  • Gunnar Henderson has recorded at least one hit in each of the Orioles’ last 14 home games.
  • Kyle Bradish has recorded seven or more strikeouts in four of his last five appearances with the Orioles as underdogs against AL opponents.

Boston Red Sox Player Prop Facts

  • Lucas Giolito has recorded six or more strikeouts in eight of his last nine appearances against AL East opponents that held a losing record.
  • Lucas Giolito has recorded a win in five of his last six appearances against AL opponents.
  • Jarren Duran has recorded a Double in four of the Red Sox’s last five road games against opponents that held a losing record.
  • Jarren Duran has hit a home run in each of the Red Sox’s last three road games against opponents that held a losing record.
  • Masataka Yoshida has recorded at least one hit in each of his last nine appearances against the Orioles after playing the previous day.

Orioles vs Red Sox Prediction 

Boston was able to stay hot with another win on Monday night to start this series, as they continue to battle the Yankees for second in the AL East. The Red Sox are 31-35 on the road this year, while the Orioles are 31-34 at home. Baltimore has lost four of their last five games and they are starting Bradish, who is making his season debut. Boston is starting Giolito, who has allowed three earned runs or fewer in four of his last five outings. I think we could see a higher scoring game here, but I will back the red hot Sox here. 

David Racey's Free Pick: Red Sox ML

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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