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Orioles vs White Sox Prediction 6/29/26 MLB Picks Today

Chicago White Sox (43-39) vs. Baltimore Orioles (39-46)
June 29, 2026 6:35 pm EDT
The Line: Baltimore Orioles -136 / Chicago White Sox 113; Over/Under: 9
(Get latest betting odds)

The Chicago White Sox and Baltimore Orioles meet Monday in MLB action at Oriole Park. Here’s an Orioles vs White Sox Prediction. This article will include an Orioles vs White Sox Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 43-39 on the year and play the Red Sox and Guardians next. The Chicago White Sox are batting .242 on the season, have a .322 OBP, and have a .416 slugging percentage. The Chicago White Sox pitching staff has a 4.25 ERA and a 1.33 WHIP. Chase Meidroth leads the Chicago White Sox with 83 hits and 27 RBI, while Colson Montgomery and Miguel Vargas have combined for 138 hits and 98 RBI.

Sean Burke gets the ball for the Chicago White Sox, and he is 5-4 with a 3.71 ERA and 87 strikeouts this season. Burke is 0-1 with a 3.00 ERA and 13 strikeouts in his career against the Baltimore Orioles.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 39-46 on the year and play the Cubs and Reds next. The Baltimore Orioles are batting .239 on the season and have a .319 OBP and a .399 slugging percentage. The Baltimore Orioles pitching staff has a 4.36 ERA and a 1.37 WHIP. Taylor Ward leads the Baltimore Orioles with 81 hits and 22 RBI, while Gunnar Henderson and Pete Alonso have combined for 157 hits and 97 RBI.

Shane Baz gets the ball for the Baltimore Orioles, and he is 4-8 with a 4.31 ERA and 81 strikeouts this season. This will be Baz’s second career game against the Chicago White Sox.

Why the Baltimore Orioles will win

  • The Orioles have won each of their last nine games against the White Sox.
  • The White Sox have lost each of their last eight games against the Orioles following a home loss.
  • The White Sox have failed to cover the run line in each of their last eight games against the Orioles following a home loss.
  • The Orioles have covered the run line in seven of their last eight home games against American League opponents that held a winning record.
  • The White Sox have trailed after 5 innings in nine of their last 10 night games against AL East opponents.
  • The Orioles have led after 3 innings in six of their last seven home games against American League opponents.

Why the Chicago White Sox will win

  • The Orioles have lost each of their last four games as home favorites after playing the previous day.
  • The road team has won each of the last six games between the White Sox and Orioles.
  • The Orioles have failed to cover the run line in seven of their last eight home games against AL Central opponents that held a winning record.
  • The White Sox have covered the run line in seven of their last eight road games following a home loss.
  • The Orioles have lost the first inning in three of their last four games against American League opponents.
  • The Orioles have trailed after 5 innings in each of their last seven Monday night games against opponents that held a winning record.

Total Runs Facts

  • Seven of the Orioles’ last eight games as favorites against the White Sox have gone UNDER the total runs line.
  • Four of the White Sox’s last five night games against AL East opponents have gone OVER the total runs line.
  • There has been no run scored during the first inning in each of the White Sox’s last four games as underdogs.
  • There has been at least one run scored in the first inning in each of the Orioles’ last four games against American League opponents.

Baltimore Orioles Player Prop Facts

  • Pete Alonso has hit a home run in each of the Orioles’ last two home games against AL opponents.
  • Shane Baz has recorded a win in four of his last five home appearances against opponents that held a winning record.
  • Shane Baz has recorded six or more strikeouts in each of his last three appearances against AL opponents that held a winning record.
  • Taylor Ward has recorded at least one hit in each of the Orioles’ last 10 night games against opponents that held a winning record.

Chicago White Sox Player Prop Facts

  • Kyle Teel has hit a home run in four of his last five appearances in night games against AL teams that held a losing record.
  • Sean Burke has recorded a win in four of his last five road appearances.
  • Sean Burke has recorded six or more strikeouts in each of his last six appearances.
  • Miguel Vargas has recorded at least one hit in each of the White Sox’s last six games.
  • Colson Montgomery ranks T7th in the league in Home Runs (20) this season.

Matchup/League Facts

  • The Orioles rank 28th in the league for strikeouts against this season (778).
  • The Orioles rank 5th in the league for walks this season (320).
  • The White Sox rank 2nd in the league for home runs this season (116).
  • The White Sox rank T27th in the league for doubles this season (113).

Orioles vs White Sox Prediction

I keep saying it, but oddsmakers don’t respect the White Sox despite them winning games and being the second most profitable team in baseball. Only the Nationals have earned more money this season than the White Sox. The Orioles have underachieved all year, and Baz has been hittable with a 4.31 ERA and 1.38 WHIP. At home through 32.2 innings, Baz has a 4.41 ERA and a .303 allowed batting average. I’ll continue to back the White Sox at favorable prices until oddmakers catch on. Give me the White Sox.

Randy Chambers's Free Pick: Chicago White Sox 113

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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