Orioles vs Yankees Prediction 9/27/26 MLB Picks Today

In this article, we will formulate an Orioles vs Yankees Prediction for this MLB matchup on Sunday, September 27^th in the final game of the regular season. Let’s take a look at the prediction for this MLB matchup.

New York Yankees Preview

The New York Yankees have a 93-68 record this season and are sitting in the 2nd place of the AL East. They have a 46-34 home record and are coming off a 6-3 home win against the Orioles.

The New York Yankees have a .235 batting average this season, .311 OBP and .409 Slugging percentage. New York’s pitching staff has a 3.24 ERA and 1.17 WHIP. Cody Bellinger is the team’s best hitter with a .264 batting average. Ben Rice leads the team in RBI with 97, adding a team-high 41 home runs.

Elmer Rodriguez (R) is the projected starting pitcher for the Yankees, and he has a 0-3 record, 5.40 ERA and 1.58 WHIP.

Baltimore Orioles Preview

The Baltimore Orioles have a 79-82 record this season and are sitting in the 4th place of the AL East. They have a 40-40 away record and are coming off a 3-6 road loss against the Yankees.

The Baltimore Orioles have a .234 batting average this season, .314 OBP and .396 Slugging percentage. Baltimore’s pitching staff has a 4.08 ERA and 1.34 WHIP. Pete Alonso is the team’s best hitter with a .267 batting average, leading the team in RBI with 113 and adding a team-high 43 home runs.

Shane Baz (R) is the projected starting pitcher for the Orioles, and he has a 6-15 record, 4.11 ERA and 1.35 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 27, 2026

• Probable Starting Pitcher: Jacob Misiorowski      Record this season: 15-5      ERA: 1.86
• Home Record: 7-1
• Last 5 against Cardinals: 3-1

Why the Milwaukee Brewers will win

• The Brewers have won each of their last seven games after playing the previous day.
• The Cardinals have lost eight of their last nine games at American Family Field.
• The Brewers have covered the run line in five of their last six games after playing the previous day.
• The Brewers have led after 5 innings in each of their last seven home games against NL Central opponents that held a losing record.
• The Brewers have led after 3 innings in five of their last six home games.
• The Brewers have won the first inning in 12 of their last 15 home games against opponents that held a losing record.

• Probable Starting Pitcher: Andre Pallante      Record this season: 12-8      ERA: 3.61
• Road Record: 7-1
• Last 5 against Brewers: 0-4

Why the St. Louis Cardinals will win

• The Brewers have lost four of their last five Sunday games as favorites.
• The Brewers have failed to cover the run line in each of their last six day games against the Cardinals following a win.
• The Cardinals have covered the run line in 12 of their last 14 games as underdogs after playing the previous day.
• The Cardinals have led after 5 innings in seven of their last eight road day games.
• The Cardinals have won the first inning in three of their last four day games against NL opponents that held a winning record.

Total Runs Facts

• Five of the Cardinals’ last six games have gone UNDER the total runs line.
• Five of the last six games between the Cardinals and Brewers at American Family Field have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of Jacob Misiorowski’s last four appearances as a starter against the Cardinals.
• There has been at least one run scored in the first inning in six of the Cardinals’ last seven day games against NL Central opponents.

Milwaukee Brewers Player Prop Facts

• Jake Bauers has hit a home run in each of his last two appearances in day games against teams that held a losing record.
• Jacob Misiorowski has recorded nine or more strikeouts in each of his last four appearances in day games against teams that held a losing record.
• William Contreras has recorded at least one hit in each of his last 12 appearances against opponents that held a losing record.
• Jacob Misiorowski ranks 1st amongst qualified players for Earned Run Average (1.86) this season.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has recorded at least one hit in each of the Cardinals’ last nine Sunday games as underdogs.
• Andre Pallante has recorded a win in seven of his last nine appearances with the Cardinals as road underdogs.
• Alec Burleson has hit a home run in each of the Cardinals’ last three games.

Matchup/League Facts

• The Brewers rank 1st in the league for hits this season (1412).
• The Brewers rank 1st in the league for on-base percentage this season (.341).
• The Cardinals rank 28th in the league for triples this season (14).
• The Cardinals rank 28th in the league for slugging percentage this season (.379).

Orioles vs Yankees Prediction

The Yankees are 7-3 in their last 10 meetings against the Orioles and are 3-1 in their last 4 meetings in New York.

In this Orioles vs Yankees Prediction, the Yankees are coming as -135 home favorites. Both pitchers have been bad, with a combined 9.55 ERA and Baz has given up 3+ runs in each of his last three starts and has been bad historically against the Yankees. Both games in this series had 12 and 9 total runs, as both teams average 10.7 runs per game combined against right-handed pitching in their last 10 games. Take the over 7.5 runs in this one.