Orioles vs Yankees Prediction 9/20/25 MLB Picks Today

In this article we will formulate an Orioles vs Yankees prediction for this MLB game on Saturday, September 20th at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 73-81 this year after they split the first two games in this series by scores of 0-7 and 4-2. In their game two win, Baltimore led 3-0 in the sixth inning and added an insurance run in the seventh to seal the victory. The Orioles recorded seven hits in the game and they were led by Mountcastle, who went 1-3 with one home run and two RBIs in the win. Baltimore started Rogers, who allowed one hit and zero earned runs over 6.0 innings for the win, while Enns allowed two earned runs in relief. 

Prior to this series, the Orioles won all three against the White Sox, but lost all three against the Blue Jays before that. Baltimore has won four of their last five games and they are last in the AL East standings. The Baltimore pitching staff has a 4.59 ERA with a 1.37 WHIP and a .259 opponent batting average, while their offense has scored 654 runs with a .238 batting average and a .307 on base percentage this season. Jackson Holliday has led Baltimore with 17 home runs and 55 RBIs, while Gunnar Henderson has added 16 home runs and 65 RBIs this year. The projected starting pitcher for Baltimore is Tomoyuki Sugano, who is 10-8 with a 4.39 ERA and a 1.32 WHIP over 149.2 innings pitched this year. 

New York Yankees Betting Preview

The New York Yankees are 86-68 this season after they lost game two by a score of 4-2 on Friday. New York cut the deficit to 3-2 in the seventh inning, but couldn’t get any closer in the loss. The Yankees recorded four hits and they committed two errors in the game, while they were led by Chisholm Jr, who went 1-4 with one home run and two RBIs in the loss. New York started Warren, who allowed four hits and one earned run over 5.1 innings for the loss, while Hill allowed one earned run in relief. 

Prior to this series, the Yankees won two out of three against the Twins and two out of three against the Red Sox. New York has won six of their last nine games and they are second in the AL East standings. The New York pitching staff has a 4.02 ERA with a 1.27 WHIP and a .232 opponent batting average, while the offense has scored 803 runs with a .250 batting average and a .330 on base percentage this season. Aaron Judge has led New York with 48 home runs and 104 RBIs, while Cody Bellinger has added 29 home runs and 97 RBIs this year. The projected starting pitcher for New York is Carlos Rodon, who is 16-9 with a 3.11 ERA and a 1.07 WHIP over 182.1 innings pitched this season. 

Why the Yankees will beat the Orioles

• The Yankees have won 12 of their last 13 games against the Orioles following a road loss.
• The Orioles have lost eight of their last nine games against AL East opponents.
• The Orioles have failed to cover the run line in eight of their last nine home games against the Yankees following a win.
• The Yankees have covered the run line in eight of their last nine games against the Orioles following a road loss.
• The Yankees have led after 3 innings in five of their last six games as favorites against AL East opponents.
• The Yankees have led after 5 innings in each of their last seven Saturday games against the Orioles.
• The Yankees have won the first inning in four of their last five games as favorites against AL East opponents.

Total Runs Facts

• Each of the Orioles’ last 13 home games have gone UNDER the total runs line.
• Each of the Yankees’ last seven games as favorites against AL East opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the last seven games between the Yankees and Orioles.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Yankees’ last seven road games against AL East opponents.

Baltimore Orioles Player Prop Facts

• Ryan Mountcastle has hit a home run in each of his last two appearances against the Yankees after playing the previous day.
• Gunnar Henderson has recorded at least one hit in each of the Orioles’ last eight home games against the Yankees.
• Dylan Carlson has recorded a Double in each of his last three home appearances against AL East opponents.

New York Yankees Player Prop Facts

• Carlos Rodon has recorded seven strikeouts in three of his last four road appearances against the Orioles.
• Trent Grisham has hit at least one home run in five of his last eight appearances in night games against AL teams that held a losing record.
• Ryan McMahon has recorded at least one hit in each of his last 19 Saturday night appearances with his team as a favorite.
• Carlos Rodon has recorded a win in four of his last five appearances against AL opponents that held a losing record.
• Anthony Volpe has recorded at least one Double in four of the Yankees’ last five games as road favorites against the Orioles.

Orioles vs Yankees Prediction 

Baltimore was able to steal a valuable win away from the Yankees on Friday and they continue to play very well in the month of September. The Orioles are 37-39 at home this year, while the Yankees are 42-37 on the road. New York has scored 29 runs in their last four games and they are facing Sugano, who has allowed 1, 3, 7, and 4 earned runs in his last four outings. Baltimore is going against Rodon, who has allowed two earned runs or fewer in five straight. Take the Yankees by at least two runs here.