Padres vs Diamondbacks Prediction 9/27/26 MLB Picks Today
Arizona Diamondbacks (86-75) vs. San Diego Padres (90-71)
September 27, 2026 3:10 pm EDT
The Line: San Diego Padres / Arizona Diamondbacks ; Over/Under:
(Get latest betting odds)
The Arizona Diamondbacks and San Diego Padres meet Sunday in MLB action at Petco Park. Here’s a Padres vs. Diamondbacks Prediction. This article will include a Padres vs. Diamondbacks Pick.
Arizona Diamondbacks Betting Preview
The Arizona Diamondbacks are 86-75 on the year. The Arizona Diamondbacks are batting .246 on the season, have a .318 OBP, and have a .403 slugging percentage. The Arizona Diamondbacks’ pitching staff has a 4.14 ERA and a 1.28 WHIP. Gabriel Moreno leads the Arizona Diamondbacks with 147 hits and 83 RBI, while Geraldo Perdomo and Ketel Marte have combined for 285 hits and 134 RBI.
Michael Soroka gets the ball for the Arizona Diamondbacks, and he is 9-5 with a 2.31 ERA and 110 strikeouts this season. Soroka is 2-0 with a 0.90 ERA and 23 strikeouts in his career against the San Diego Padres.
San Diego Padres Betting Preview
The San Diego Padres are 90-71 on the year. The San Diego Padres are batting .244 on the season, have a .319 OBP, and have a .398 slugging percentage. The San Diego Padres’ pitching staff has a 3.99 ERA and a 1.30 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 181 hits and 83 RBI, while Jackson Merrill and Ty France have combined for 284 hits and 158 RBI.
Randy Vasquez gets the ball for the San Diego Padres, and he is 10-6 with a 4.01 ERA and 85 strikeouts this season. Vasquez is 1-0 with a 3.03 ERA and 18 strikeouts in his career against the Arizona Diamondbacks.
Why the San Diego Padres will win
- The Padres have won each of their last seven day games after playing the previous day.
- The Diamondbacks have lost five of their last six games at Petco Park against teams that held a winning record.
- The Diamondbacks have failed to cover the run line in five of their last six games at Petco Park against teams that held a winning record.
- The Padres have covered the run line in four of their last five home games against NL opponents that held a winning record.
- The Padres have led after 5 innings in each of their last seven day games.
- The Diamondbacks have lost the first inning in three of their last four games at Petco Park against opponents that held a winning record.
- The Padres have led after 3 innings in each of their last four home day games.
Why the Arizona Diamondbacks will win
- The Diamondbacks have won nine of their last 10 day games against NL West opponents.
- The Padres have lost each of their last four games against the Diamondbacks following a win.
- The Diamondbacks have covered the run line in seven of their last eight road games against NL West opponents following a loss.
- The Padres have failed to cover the run line in each of their last four games against the Diamondbacks following a win.
- The Diamondbacks have won the first inning in five of their last six games.
- The Diamondbacks have led after 3 innings in four of their last five games.
- The Diamondbacks have led after 5 innings in six of their last seven games.
Total Runs Facts
- Each of the Padres’ last seven home games has gone OVER the total runs line.
- Five of the Diamondbacks’ last six games after playing the previous day have gone OVER the total runs line.
- There has been at least one run scored in the first inning in 12 of the Diamondbacks’ last 13 games against NL West opponents.
- There has been at least one run scored in the first inning in eight of the last nine games between the Diamondbacks and Padres at Petco Park.
San Diego Padres Player Prop Facts
- Jackson Merrill has recorded at least one hit in each of the Padres’ last seven home games against NL opponents that held a winning record.
- Manny Machado has hit at least one home run in each of the Padres’ last three day games against NL West opponents that held a winning record.
Arizona Diamondbacks Player Prop Facts
- Michael Soroka has recorded five or more strikeouts in each of his last four appearances against opponents that held a winning record.
- Nolan Arenado has recorded at least one hit in each of the Diamondbacks’ last 12 games.
- Michael Soroka has recorded a win in four of his last five road appearances against NL West opponents.
- Nolan Arenado has hit a home run in four of the Diamondbacks’ last five days’ games.
Matchup/League Facts
- The Padres rank 3rd in the league for steals this season (163).
- The Padres rank 24th in the league for doubles this season (233).
- The Diamondbacks rank 1st in the league for triples this season (42).
- The Diamondbacks rank 29th in the league for strikeouts this season (1131).
Padres vs Diamondbacks Prediction
The Diamondbacks are playing for a playoff spot while the Padres already punched their ticket. Soroka has been solid this season with a 3.31 ERA and 1.09 WHIP, and he’s allowed 7 hits and 5 earned runs in his last 16 innings. Vasquez is having a solid September as well, but over the season he’s been far more hittable with a 4.01 ERA and 1.30 WHIP. I’ll side with the Diamondbacks, who have the sharper pitcher on the mound and have more to play for at this point. Give me the road team.