Padres vs Giants Prediction 4/29/25 MLB Picks Today

The San Francisco Giants and the San Diego Padres meet Tuesday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Padres vs Giants Prediction.

Starting Pitching Matchup

The San Francisco Giants will send out Logan Webb for the start here, and Webb is 3-1 with a 1.98 ERA and 44 strikeouts this season. In his last five starts against the Padres, Webb is 2-1 with a 3.09 ERA and 22 strikeouts. Nick Pivetta will get the start for the Padres here and is 4-1 with a 1.20 ERA and 30 strikeouts this season. In his career, Pivetta is 1-1 with a 3.00 ERA and 10 strikeouts against the Giants.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to build on their series win over the Texas Rangers after a 3-2 win in Sunday’s series finale brought San Fran to 19-10 on the year. After this series, the Giants will take on the Colorado Rockies at home.

Giants Win Back-To-Back Series

Jung Hoo Lee leads the Giants with 35 hits, including a team-high 11 doubles along with a pair of triples, 3 home runs, and 16 RBIs with 3 stolen bases, while Heliot Ramos has 28 hits with 7 doubles, 3 home runs, and 10 RBIs. Wilmer Flores also has a team-high 7 home runs and 28 RBIs, while Mike Yastrzemski has 4 home runs with 13 RBIs and 6 doubles, and Tyler Fitzgerald has a team-high 5 stolen bases as well on the year.

Why the San Francisco Giants will win

• The road team has won each of the last five games between the Giants and Padres.
• The Padres have lost each of their last four games.
• The Giants have covered the run line in seven of their last eight games as road favorites against National League opponents.
• The Padres have failed to cover the run line in each of their last four games.

San Francisco Giants Player Prop Facts

• Matt Chapman has recorded a Double in three of the Giants’ last four games as favorites against NL West opponents.
• Matt Chapman has hit a home run in each of the Giants’ last two road games against opponents that held a winning record.
• Wilmer Flores has recorded at least one RBI in each of the Giants’ last six night games against NL teams that held a winning record.
• Heliot Ramos has scored at least one run in each of the Giants’ last seven road games against NL opponents.
• Logan Webb has recorded a win in each of his last three appearances against opponents that held a winning record.
• Heliot Ramos has recorded at least one Single in each of the Giants’ last seven night games against NL West opponents that held a winning record.
• Logan Webb has recorded six or more strikeouts in each of his last four appearances in night games.
• Heliot Ramos has recorded at least one hit in each of the Giants’ last 13 road games against NL opponents.
• Logan Webb ranks T6th in the league for total Strikeouts (44) this season.

San Diego Padres Recap

The San Diego Padres come into this game looking to rebound from a 4-2 loss at the hands of the Tampa Bay Rays last time out to fall to 17-11 on the year. After this series, the Padres will head on the road for a series against the Pittsburgh Pirates.

Padres Lose 4 Straight & 7 Of Last 9

Manny Machado has 28 hits, including a team-high 10 doubles and 6 stolen bases, while Fernando Tatis Jr. has 36 hits with a team-high 8 home runs and 18 RBIs, along with 7 stolen bases of his own this season. Luis Arraez has added 25 hits with 3 doubles, while Jackson Merrill’s added 14 hits with 3 home runs and 10 RBIs as well. Xander Bogaerts also has 8 doubles and 4 stolen bases this season. Gavin Sheets also has 4 doubles, 3 home runs, and 12 RBIs as well this season.

Why the San Diego Padres will win

• The Giants have lost each of their last six games as road favorites against the Padres following a win.
• The Padres have won eight of their last nine games as underdogs against NL West opponents following a loss.
• The Padres have covered the run line in each of their last nine games as underdogs against the Giants.
• The Giants have failed to cover the run line in each of their last seven games against National League opponents following a home win.

San Diego Padres Player Prop Facts

• Manny Machado has hit at least one home run in each of the Padres’ last two games as home underdogs against NL West opponents.
• Nick Pivetta has recorded a win in four of his last five appearances.
• Luis Arraez has recorded two or more hits in each of the Padres’ last five games against the Giants.
• Manny Machado has recorded at least one RBI in six of the Padres’ last seven games as home underdogs.
• Luis Arraez has scored at least one run in each of the Padres’ last six games against the Giants.
• Nick Pivetta has recorded six or more strikeouts in each of his last seven appearances in night games.
• Luis Arraez has recorded at least one Single in each of the Padres’ last six games against the Giants.
• Jake Cronenworth has recorded a Double in three of his last four appearances with the Padres as home underdogs.
• Nick Pivetta ranks T3rd in the league for Wins (4) this season.

Total Runs Facts

• Eight of the Giants’ last nine road games against National League opponents have gone OVER the total runs line.
• Seven of the Padres’ last eight games have gone UNDER the total runs line.

Padres vs Giants Prediction

I’m on the under in this one. Both Webb and Pivetta have been solid this season, and we’ve seen both play a lot of low-scoring games as of late. The Padres, offensively, have watched the offense dry up over the last couple of weeks, and the Giants have been inconsistent at times when it comes to run production at the plate. I think this could be a 3-2 kind of game for either side, so even though it’s a low total in this game, I have to ride with the under in this one.