Padres vs Giants Prediction 4/30/25 MLB Picks Today

In this article, we will formulate a Padres vs Giants prediction for this MLB game on Wednesday, April 30, at PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Betting Preview

The San Francisco Giants (19-11, 10-7 Away) came to San Diego following two series wins over the Brewers and Rangers at home. In Game 1 of the current series against the Padres, LaMonte Wade Jr. led the offense with two RBI, but the Giants still lost 7-4. Logan Webb took the loss after allowing five runs on nine hits with six strikeouts and one walk over 5.0 innings of work.

This season, the Giants average 4.63 runs per game (10th in the MLB) on a .229/.309/.377 slash line. Regarding pitching, the Giants’ staff has a 3.53 ERA (10th) and 1.25 WHIP (12th). Wilmer Flores leads the Giants with a .238 batting average, seven home runs, and 28 RBI this season.

The projected starting pitcher for the Giants is Landen Roupp, who is 2-1 in five starts this season, with a 4.56 ERA and 1.52 WHIP in 25.2 innings.

San Diego Padres Betting Preview

The San Diego Padres (18-11, 13-4 Home) went through their worst period of the season, during which they suffered four consecutive defeats. After scoring just three runs in that span and being swept by the Rays, the Padres opened the series against San Francisco with a 7-4 victory. Xander Bogaerts led the offense with three RBI, while Nick Pivetta got the win after allowing three runs on five hits with nine strikeouts and three walks in 5.1 innings.

This year, the Padres average 3.90 runs per game (22nd in the MLB) on a .257/.325/.388 triple-slash. When it comes to pitching, the Padres’ staff has a 2.86 ERA (2nd) and 1.13 WHIP (4th). Fernando Tatis Jr. leads the Padres with a .330 batting average, eight home runs, and 18 RBI this season.

Michael King will take the mound for the Padres on Wednesday. The 29-year-old right-hander has a 3-1 record in six starts this year with a 2.18 ERA and 1.06 WHIP in 33.0 innings.

Why the Padres will beat the Giants

• The Padres have won 10 of their last 11 home games against National League opponents.
• The Giants have lost seven of their last eight Wednesday day games against teams that held a winning record.
• The Padres have covered the run line in each of their last 10 games at Petco Park following a win.
• The Giants have failed to cover the run line each of their last five games against teams that held a winning record.
• The Padres have won the first inning in each of their last three games against NL West opponents.
• The Padres have led after 3 innings in five of their last six home games against National League opponents.
• The Giants have trailed after 5 innings in each of their last three day games against National League opponents.

Total Runs Facts

• Each of the Giants’ last nine games as road underdogs have gone OVER the total runs line.
• Eight of the Padres’ last nine games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Padres’ last seven home games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Giants’ last five games.

Matchup/League Facts

• The Padres rank 2nd in the league for ERA this season (2.86).
• The Padres rank T2nd in the league for home runs allowed this season (22).
• The Giants rank 24th in the league for batting average this season (.229).
• The Giants rank 7th in the league for strikeouts this season (267).

Padres vs Giants Prediction

The Padres won six of the previous ten H2H encounters, including the last four. I am leaning toward San Diego in this one because of the pitching matchup. I trust Michael King more; he allowed just two earned runs in his last three starts. Landen Roupp isn’t bad so far in the season, but King has an advantage in this matchup. I don’t expect to see a lot of runs, but I do back the Padres to edge out the Giants.