Padres vs Giants Prediction 6/4/25 MLB Picks Today

The San Diego Padres are visiting the San Francisco Giants on Wednesday, June 4^th at Oracle Park in the third game of this series, with the Padres having a 2-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s the Padres vs Giants Prediction. We will examine:

The San Francisco Giants’ recent form and player performance

The San Diego Padres’ recent form and player performance

Recent betting trends and streaks involving the San Francisco Giants

Recent betting trends and streaks involving the San Diego Padres

Recent betting trends in games played between the San Diego Padres vs San Francisco Giants

A summary that ties it all together and produces a favorable betting outcome for the San Diego Padres vs San Francisco Giants game

San Francisco Giants Preview

The San Francisco Giants have a 33-28 record this season and are sitting in third place in the NL West. They have a 17-11 home record and are 28-33 in over/under. They are coming off a 2-3 home defeat by the Padres, and are 2-6 in their last 8 games. Their last 11 game have gone under the total, and they are playing the Rockies and the Braves next.

The Giants have a .231 batting average this season, a .309 OBP, and a .370 Slugging percentage. San Francisco’s pitching staff has a 3.03 ERA and 1.20 WHIP.  Heliot Ramos leads the Giants with 67 hits and is the team’s best hitter, with a .293 batting average, adding a team-high 11 home runs. Wilmer Flores leads the team in RBI with 47.

Kyle Harrison (L) will take the mound for the Giants, and he has a 1-1 record, 2.51 ERA, and 0.98 WHIP. He has been terrible in his two home starts, with a 7.71 ERA, but he is coming off a shutout start in 5 innings pitched against the Marlins. In his previous start against the Padres last season, he gave up 2 runs in 6 innings pitched.

San Diego Padres Preview

The San Diego Padres have a 35-24 record this season and are sitting in second place in the NL West. They have a 15-14 road record, and are 24-33 in over/under. The Padres are coming off a 3-2 road victory over the Giants, and are 7-2 in their last 9 games. Under is 4-1 in their last 5 games, and they are playing the Dodgers and the Brewers next.

The Padres have a .248 batting average this season, a .315 OBP, and a .380 Slugging percentage. San Diego’s pitching staff has a 3.51 ERA and 1.20 WHIP.  Manny Machado leads the Padres with 69 hits and a team-high .315 batting average. Gavin Sheets leads the team in RBI, with 34, while Fernando Tatis Jr. adds a team-high 13 home runs.

Nick Pivetta (R) will take the mound for the Padres, and he has a 6-2 record, 2.74 ERA, and 1.01 WHIP. He has weaker on the road, with a 4.32 ERA across five road starts, but he has given up 2 runs or less in his last three starts. In his previous start against the Giants this season, he gave up 3 runs in 5.1 innings of work.

Why the San Francisco Giants will win

• The underdogs have won four of the Giants’ last five games at Oracle Park.
• The Padres have lost each of their last three games as road favorites.
• The Giants have covered the run line in each of their last six games as underdogs against National League opponents.
• The Padres have failed to cover the run line in nine of their last 10 games as road favorites following an extra innings win.
• The Padres have trailed after 3 innings in three of their last four road games against National League opponents that held a winning record.
• The Padres have trailed after 5 innings in five of their last six road games against National League opponents that held a winning record.

Why the San Diego Padres will win

• The Padres have won each of their last eight games after going to extra innings.
• The Giants have lost each of their last six games against teams that held a winning record.
• The Padres have covered the run line in each of their last eight games after going to extra innings.
• The Giants have failed to cover the run line in each of their last seven games at Oracle Park.
• The Padres have led after 5 innings in six of their last seven games as favorites against NL West opponents.
• The Padres have won the first inning in five of their last six games as favorites against the Giants at Oracle Park.
• The Padres have led after 3 innings in five of their last six games as favorites against NL West opponents.

Total Runs Facts

• Each of the Giants’ last 11 games have gone UNDER the total runs line.
• Each of the Padres’ last four games as favorites against NL West opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Giants’ last six night games at Oracle Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last four games as road favorites against National League opponents.

Matchup/League Facts

• The Giants rank 1st in the league for home runs allowed this season (41).
• The Giants rank 2nd in the league for ERA this season (3.03).
• The Padres rank 1st in the league for strikeouts against this season (409).
• The Padres rank 4th in the league for hits allowed this season (441).

Padres vs Giants Prediction

The Padres have won their last 7 meetings against the Giants, including all four this season and their last four visits in San Francisco. Under is 5-1 in their last 6 meetings in San Francisco.

In this Padres vs Giants Prediction, both teams are coming at a pick ’em price. Both teams have almost identical overall records, but the Giants have been strong at home, while the Padres have been mediocre on the road. The Padres have won both games of this series, they are in far better form, and have been dominating the Giants in their recent meetings. But both pitchers have been excellent with a combined 5.25 ERA, and both teams have two of the three best bullpens in the league. Both games of this series had five and one total runs, and I don’t see this being a high-scoring game. Take the under 7 runs.