Padres vs Guardians Prediction 4/1/25 MLB Picks Today

In this article, we will formulate a Padres vs Guardians prediction for this MLB game on Tuesday, April 1, at  PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.

Cleveland Guardians Betting Preview

The Cleveland Guardians (2-2, 2-2 Away) won the opening series of the season against the divisional rivals Kansas City Royals. The Guardians won that series 2-1 and continued their road trip with a 7-2 loss to the San Diego Padres in Game 1 of this series. Starter Luis Ortiz had a horrendous display as he took a loss after allowing seven runs on nine hits with two strikeouts and four walks in 4.2 innings.

This season, the Guardians average 5.33 runs per game (7th in the MLB) on a .263/.336/.485 slash line. When it comes to pitching, the Guardians’ staff has a 2.67 ERA (10th) and 1.07 WHIP (10th). Kyle Manzardo leads the Guardians with a .385 batting average, two home runs, and six RBI this season.

The projected starting pitcher for the Guardians is Logan Allen, who had an 8-5 record in 20 starts last season with a 5.73 ERA and 1.58 WHIP over 97.1 innings of work.

San Diego Padres Betting Preview

The San Diego Padres (5-0, 5-0 Home) started this season on a high note with five consecutive wins. The Padres swept the Atlanta Braves over a four-game series, keeping the visitors off the scoreboard in the final two games. After that, San Diego opened the current series against the Guardians with a 7-2 win, thanks to Gavin Sheets, who recorded four RBI. A 5-0 start is the best in the Padres’ history.

This year, the Padres average 4.25 runs per game (12th in the MLB) on a .270/.336/.418 triple-slash. When it comes to pitching, the Padres’ staff has a 1.75 ERA (4th) and 0.94 WHIP (5th). Gavin Sheets leads the Padres with a .500 batting average, one home run, and five RBI this season.

Michael King will take the mound for the Padres on Tuesday. The 29-year-old right-hander had a 13-9 record last season in 30 starts with a 2.95 ERA and 1.19 WHIP in 173.2 innings. King already started one game this season, and it was in a 7-4 win over the Braves, where he struggled in 2.2 innings and allowed three runs on four hits with three strikeouts and four walks.

Why the Guardians will beat the Padres

• The Guardians have won each of their last six Tuesday night games as underdogs against National League opponents.
• The Padres have lost three of their last four Tuesday night games as favorites against American League opponents.
• The Guardians have covered the run line in 14 of their last 15 night games against National League opponents following a road loss.
• The Padres have failed to cover the run line in nine of their last 11 night games at Petco Park following a home win.

Why the Padres will beat the Guardians

• The Padres have won 12 of their last 13 home games.
• The Guardians have lost seven of their last eight games against NL West opponents that held a winning record.
• The Guardians have failed to cover the run line each of their last five road games against teams that held a winning record.
• The Padres have covered the run line in each of their last four home games against American League opponents after playing the previous day.
• The Padres have led after 5 innings in six of their last eight games as favorites.
• The Guardians have trailed after 3 innings in each of their last three road night games.

Total Runs Facts

• Five of the Guardians’ last six road games after playing the previous day have gone OVER the total runs line.
• Six of the Padres’ last eight home games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last seven games as home favorites.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Guardians’ last five games at Petco Park.

Padres vs Guardians Prediction

The teams have traded victories in the past few years, as each recorded five in the last ten H2H duels. The Padres were better in the last three, including the Game 1 of this series, but I’ll avoid betting on the winner here. King had a shaky start against the Braves, and I am not sure whether he had enough time to recover and bounce back in this one. He was excellent in his previous start against the Guardians, allowing a 1.29 ERA in 7.0 innings, but I think he will surrender multiple runs in this start. Allen allowed a .308 BA with a homer and four RBI in 13-at-bats against the Padres in his career. I like the run total for this clash, and I am going with Over.