Padres vs Rays Prediction 4/27/25 MLB Picks Today

The Tampa Bay Rays and San Diego Padres meet Sunday in MLB action at Progressive Field. Here’s a Padres vs Rays Prediction. This article will include a Padres vs Rays Pick.

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 13-14 on the year and play the Royals, Yankees, and Phillies next. The Tampa Bay Rays are batting .252 on the season, have a .318 OBP, and a .390 slugging percentage. The Tampa Bay Rays pitching staff has a 3.51 ERA and a 1.15 WHIP. Yandy Diaz leads the Tampa Bay Rays with 28 hits and 13 RBI, while Junior Caminero and Jonathan Aranda have combined for 50 hits and 25 RBI.

Zack Littell gets the ball for the Tampa Bay Rays, and he is 0-5 with a 5.28 ERA and 21 strikeouts this season. Littell is 1-0 with a 5.40 ERA and 17 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 17-10 on the year and play the Giants, Pirates, and Yankees next. The San Diego Padres are batting .257 on the season, have a .327 OBP, and a .392 slugging percentage. The San Diego Padres pitching staff has a 2.77 ERA and a 1.13 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 35 hits and 18 RBI, while Manny Machado and Luis Arraez have combined for 53 hits and 17 RBI.

Randy Vasquez gets the ball for the San Diego Padres, and he is 1-2 with a 3.97 ERA and 9 strikeouts this season. This will be Vasquez’s second career game against the Tampa Bay Rays.

Why the San Diego Padres will win

• The Padres have won each of their last seven day games against teams that held a losing record.
• The Rays have lost each of their last six day games following a win.
• The Padres have covered the run line each of their last six day games against teams that held a losing record.
• The Rays have failed to cover the run line in each of their last six day games following a win.
• The Padres have led after 3 innings in each of their last four home day games.
• The Padres have led after 5 innings in each of their last four home day games.
• The Rays have lost the first inning in each of their last three day games against opponents that held a winning record.

Why the Tampa Bay Rays will win

• The Rays have won each of their last four games as underdogs.
• The Padres have lost each of their last four games as favorites against American League opponents.
• The Rays have covered the run line in seven of their last eight games as underdogs after playing the previous day.
• The Padres have failed to cover the run line in each of their last five games as favorites against American League opponents.
• The Rays have led after 3 innings in each of their last five games at Petco Park against opponents that held a winning record.
• The Rays have led after 5 innings in five of their last six games at Petco Park against opponents that held a winning record.
• The Rays have won the first inning in three of their last four day games against National League opponents.

San Diego Padres Player Prop Facts

• Fernando Tatis Jr. has recorded a Double in four of the Padres’ last five home games against the Rays.
• Gavin Sheets has scored at least one run in seven of his last eight appearances in day games against AL East teams that held a losing record.
• Fernando Tatis Jr. has recorded an RBI in five of the Padres’ last six games as home favorites against AL East opponents.
• Manny Machado has recorded at least one hit in each of his last 13 appearances against AL East opponents that held a losing record.
• Luis Arraez has recorded at least one Single in each of his last 10 appearances against AL East opponents.
• Jackson Merrill has hit a home run in each of his last two appearances with the Padres against AL opponents.
• Fernando Tatis Jr. ranks 4th amongst qualified players for Slugging Percentage (.634) this season.

Tampa Bay Rays Player Prop Facts

• Brandon Lowe has hit a home run in four of his last eight appearances in day games against NL teams that held a winning record.
• Brandon Lowe has recorded at least one RBI in four of his last five appearances in day games against teams that held a winning record.
• Danny Jansen has scored a run in eight of his last nine appearances in day games against NL teams that held a winning record.
• Yandy Diaz has recorded at least one Single in 11 of his last 12 appearances against NL opponents that held a winning record.
• Brandon Lowe has recorded at least one hit in each of his eight previous appearances in day games against NL West teams that held a winning record.
• Jonathan Aranda ranks 7th amongst qualified players for On Base Percentage (.419) this season.

Padres vs Rays Prediction

The Rays are having a week that includes four straight wins and an offense that’s picked up. The problem in this spot is that Littell is on the mound, a pitcher who has allowed 29 hits and 17 runs in 29 innings. Littell has allowed 16 runs alone in his last 23 innings. Littell has lost each of the last six games he’s pitched.

The Padres have lost three straight games and have scored a combined one run in those games, but this feels like what the doctor ordered for them to break out of this funk. Vasquez was rocked in his last outing, but he’s been solid overall, and that includes an ERA under four on the season. Vasquez has allowed one run in 11 home innings. Give me the Padres and the cheap price, given the gap between starting pitchers.