Padres vs Twins Prediction 8/29/25 MLB Picks Today

In this article, we will formulate a Padres vs Twins Prediction for this MLB game on Friday, August 29^th at the Target Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Minnesota Twins Preview

The Minnesota Twins have a 60-73 record this season and are sitting on the 4^th place of the AL Central. The Twins have a 33-31 home record and are 60-64 in over/under. They are coming off an 8-9 road defeat by the Blue Jays, and are 1-4 in their last 5 games. Over is 6-1 in their last 7 games and are playing the White Sox and the Royals next.

The Twins have a .238 batting average this season, .310 OBP and .398 Slugging percentage. Minnesota’s pitching staff has a 4.44 ERA and 1.31 WHIP. Byron Buxton leads the Twins with 104 hits, adding team-highs both in RBI, with 64, and in home runs, with 27. He is also the team’s best hitter with a .269 batting average.

Zebby Matthews (R) is the projected starting pitcher for the Twins, and he has a 3-4 record, 5.30 ERA and 1.52 WHIP.

San Diego Padres Preview

The San Diego Padres have a 75-59 record this season and are sitting on the second place of the NL West. They have a 32-37 road record, and are 56-74 in over/under. The Padres are coming off a 3-4 road defeat by the Mariners, and are 1-3 in their last 4 games. Over is 3-1 in their last 4 games and are playing the Orioles and the Rockies next.

The Padres have a .252 batting average this season, .322 OBP and .386 Slugging percentage. San Diego’s pitching staff has a 3.60 ERA and 1.19 WHIP. Manny Machado leads the Padres with 149 hits and is the team’s best hitter with a .288 batting average. He also leads the team in RBI, with 78, and in home runs, with 21.

Nestor Cortes (L) is the projected starting pitcher for the Padres, and he has a 2-2 record, 4.66 ERA and 1.34 WHIP.

Why the Minnesota Twins will win

• The Twins have won each of their last five games as home underdogs against National League opponents following a road loss.
• The Padres have lost seven of their last eight games as road favorites against American League opponents following a loss.
• The Padres have failed to cover the run line in each of their last nine games as road favorites against American League opponents following a road loss.
• The underdogs have covered the run line in seven of the last eight games between the Padres and Twins.
• The Padres have lost the first inning in four of their last five night games against American League opponents that held a losing record.
• The Padres have trailed after 5 innings in each of their last six road games.
• The Twins have led after 3 innings in four of their last five games as home underdogs against National League opponents.

Why the San Diego Padres will win

• The Padres have won each of their last eight night games against AL Central opponents following a road loss.
• The Twins have lost six of their last seven games at Target Field.
• The Padres have covered the run line in seven of their last eight night games against AL Central opponents following a road loss.
• The Twins have failed to cover the run line in seven of their last eight home games following a road loss.
• The Twins have trailed after 3 innings in eight of their last nine games.
• The Twins have lost the first inning in four of their last five night games against opponents that held a winning record.
• The Padres have led after 5 innings in six of their last seven games as favorites.

Total Runs Facts

• Seven of the Padres’ last eight night games against American League opponents have gone OVER the total runs line.
• Each of the Twins’ last four games as underdogs have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last eight Friday games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last four games.

Matchup/League Facts

• The Twins rank 3rd in the league for walks allowed this season (368).
• The Twins rank 26th in the league for opponent batting average this season (.257).
• The Padres rank 1st in the league for opponent batting average this season (.223).
• The Padres rank 1st in the league for hits allowed this season (977).

Padres vs Twins Prediction

Both teams are tied 5-5 wins in their last 10 head-to-head meetings, but the Twins are 3-1 in their last 4 meetings in Minnesota. Over is 3-0 in their last 3 meetings.

In this Padres vs Twins Prediction, the Padres are coming as road favorites. Both pitchers have been shaky at best this season, but Cortes has been in good form lately, with a 2.33 ERA across his last five starts, coming off a shutout start against the Dodgers. San Diego has the best bullpen in baseball to back him up, and the Twins struggle against left-handed pitching, so this is a San Diego spot. Take the San Diego Padres on the moneyline on the road.