Philadelphia Phillies vs St. Louis Cardinals Prediction 8/22/26 MLB Picks Today

The St. Louis Cardinals and the Philadelphia Phillies meet Saturday in MLB action from Citizens Bank Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. Philadelphia Phillies prediction.

Starting Pitching Matchup

The St. Louis Cardinals did not have a starting pitcher announced at the time that this article was posted. Andrew Painter will get the start for the Phillies and is 2-8 with a 6.43 ERA and 71 strikeouts this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to rebound from a 7-6 loss at the hands of the Philadelphia Phillies on Friday to sit at 66-64 this season. After this series, the Cardinals will take on the Orioles in a series at home.

Cardinals Alternate Wins & Losses In 6 Straight

Entering Friday, Jordan Walker has 140 hits, 28 doubles, 26 home runs and 94 RBIs while Alec Burleson has 141 hits with 33 doubles, 21 home runs and 93 RBIs. JJ Wetherholt has 116 hits with 16 home runs and 46 RBIs while Ivan Herrera has 117 hits with 23 doubles, 14 home runs and 53 RBIs. Masyn Winn’s added 103 hits with 19 doubles and 51 RBIs and Nathan Church has 77 hits with 9 home runs and 41 RBIs this season.

Philadelphia Phillies Recap

The Philadelphia Phillies come into this game looking to add on to their win over the Cardinals on Friday to improve to 71-58 this season. After this series, the Phillies will head on the road for a series against the Seattle Mariners.

Phillies Win 7 Consecutive

Going into Friday, Kyle Schwarber has 111 hits with 15 doubles, 37 home runs and 74 RBIs. Brandon Marsh has 122 hits with 17 doubles, 17 home runs and 54 RBIs while Justin Crawford also has 93 hits with 17 doubles, 4 triples, 2 home runs and 31 RBIs. Trea Turner has 125 hits with 22 doubles, 17 home runs and 49 RBIs and Bryce Harper’s added 116 hits with 23 doubles, 25 home runs and 72 RBIs this season.

St. Louis Cardinals @ Philadelphia Phillies Betting Trends: August 22, 2026

• Probable Starting Pitcher: Andrew Painter      Record this season: 2-8      ERA: 6.43
• Home Record: 1-5
• Last 5 against Cardinals: 1-0

Why the Philadelphia Phillies will win

• The Phillies have won each of their last seven games.
• The Cardinals have lost each of their last nine Saturday games as underdogs against NL East opponents.
• The Phillies have covered the run line in each of their last six Saturday games against the Cardinals.
• The Cardinals have failed to cover the run line in six of their last seven games after going to extra innings.
• The Phillies have led after 3 innings in seven of their last eight games against National League opponents that held a winning record.
• The Phillies have led after 5 innings in six of their last seven home games against National League opponents.

• Probable Starting Pitcher: Quinn Mathews      Record this season: 0-1      ERA: 3.00
• Road Record: 0-1
• Last 5 against Phillies: –

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last six games as road underdogs against NL East opponents following a loss.
• The Phillies have lost three of their last four games as home favorites against the Cardinals following a win.
• The Cardinals have covered the run line in each of their last eight games against the Phillies.
• The Phillies have failed to cover the run line in each of their last seven games against the Cardinals following a win.
• The Cardinals have won the first inning in each of their last three games against opponents that held a winning record.
• The Cardinals have led after 5 innings in seven of their last eight games.

Total Runs Facts

• Eight of the Phillies’ last nine home games have gone OVER the total runs line.
• Eight of the Cardinals’ last nine road games after going to extra innings have gone UNDER the total runs line.
• There has been no run scored during the first inning in nine of the Phillies’ last 10 games against NL Central opponents.
• There has been at least one run scored in the first inning in five of the Cardinals’ last six road games against NL East opponents.

Philadelphia Phillies Player Prop Facts

• Trea Turner has hit a home run in three of the Phillies’ last five home games against NL Central opponents.
• Andrew Painter has recorded four or more strikeouts in each of his last three appearances in night games.
• Bryan De La Cruz has recorded at least one hit in each of his last 10 appearances with his team as a home favorite against NL Central opponents.
• Luis Arraez ranks 1st in the league in Hits (158) this season.

St. Louis Cardinals Player Prop Facts

• Jordan Walker has hit a home run in each of the Cardinals’ last three games.
• Blaze Jordan has recorded at least one hit in each of his last 13 appearances with the Cardinals as road underdogs.
• Jordan Walker ranks 5th in the league in Hits (143) this season.

Matchup/League Facts

• The Phillies rank 1st in the league for strikeouts this season (1272).
• The Phillies are one of only three teams in the league to rank top 10 in both strikeouts and walks allowed this season.
• The Cardinals rank T3rd in the league for home runs allowed this season (126).
• The Cardinals rank 4th in the league for strikeouts against this season (1012).

St. Louis Cardinals vs. Philadelphia Phillies Prediction

I’m backing the Cardinals in this one. I get the case to be made for either side in this game, but I just do not trust Andrew Painter as a starting option right now at the Major League level, and I came into this one thinking that this was probably the Cardinals’ best shot at a win in this series. I think Painter struggles again and the Cards get it done. Give me St. Louis.