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Phillies vs Astros Prediction 9/10/26 MLB Picks Today

Houston Astros (74-72) vs. Philadelphia Phillies (82-64)
September 10, 2026 1:05 pm EDT
The Line: Philadelphia Phillies -184 / Houston Astros 152; Over/Under: 8.5
(Get latest betting odds)

The Houston Astros and Philadelphia Phillies meet Thursday in MLB action at Citizens Bank Park. Here’s a Phillies vs Astros Prediction. This article will include a Phillies vs Astros Pick.

Houston Astros Betting Preview

The Houston Astros are 74-72 on the year and play the Royals and Rays next. The Houston Astros are batting .241 on the season, have a .315 OBP, and have a .410 slugging percentage. The Houston Astros’ pitching staff has a 4.55 ERA and a 1.35 WHIP. Yordan Alvarez leads the Houston Astros with 162 hits and 96 RBI, while Isaac Paredes and Christian Walker have combined for 249 hits and 162 RBI.

Cristian Javier gets the ball for the Houston Astros, and he is 2-5 with a 5.98 ERA and 50 strikeouts this season. This will be Javier’s second career game against the Philadelphia Phillies.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 82-64 on the year and play the Braves and Nationals next. The Philadelphia Phillies are batting .243 on the season, with a .312 OBP and a .401 slugging percentage. The Philadelphia Phillies’ pitching staff has a 4.00 ERA and a 1.27 WHIP. Trea Turner leads the Philadelphia Phillies with 141 hits and 56 RBI, while Bryce Harper and Brandon Marsh have combined for 270 hits and 140 RBI.

Zack Wheeler gets the ball for the Philadelphia Phillies, and he is 12-5 with a 3.23 ERA and 163 strikeouts this season. Wheeler is 1-1 with a 1.00 ERA and 21 strikeouts in his career against the Houston Astros.

Why the Philadelphia Phillies will win

  • The Phillies have won each of their last six day games against AL opponents.
  • The Astros have lost four of their last five day games against teams that held a winning record.
  • The Phillies have covered the run line in 10 of their last 11 games against AL West opponents that held a winning record.
  • The Astros have failed to cover the run line in five of their last six day games following a loss.
  • The Astros have trailed after 3 innings in four of their last five day games against opponents that held a winning record.
  • The Astros have trailed after 5 innings in each of their last six day games against NL opponents.

Why the Houston Astros will win

  • The Astros have won 11 of their last 12 games as road underdogs following a loss.
  • The Phillies have lost four of their last five games as home favorites against AL opponents following a win.
  • The Astros have covered the run line in 15 of their last 16 games as road underdogs following a loss.
  • The Phillies have failed to cover the run line in seven of their last eight days’ games against AL opponents following a home win.
  • The Astros have led after 3 innings in four of their last five games against NL East opponents that held a winning record.
  • The Astros have led after 5 innings in each of their last four games against the Phillies.

Total Runs Facts

  • Each of the Phillies’ last seven home games against AL West opponents have gone OVER the total runs line.
  • Six of the Astros’ last seven games after playing the previous day have gone UNDER the total runs line.
  • There has been at least one run scored in the first inning in each of the Astros’ last seven games.
  • There has been at least one run scored in the first inning in each of Zack Wheeler’s last four appearances as a starter.

Philadelphia Phillies Player Prop Facts

  • Kyle Schwarber has hit a home run in four of the Phillies’ last five games.
  • Zack Wheeler has recorded seven or more strikeouts in seven of his last eight home appearances.
  • Luis Arraez has recorded at least one hit in each of his last 15 home appearances against AL West opponents.
  • Zack Wheeler has recorded a win in each of his last four appearances in day games against teams that held a winning record.

Houston Astros Player Prop Facts

  • Cam Smith has hit at least one home run in three of his last four road appearances against NL opponents that held a winning record.
  • Cristian Javier has recorded five or more strikeouts in three of his last four appearances.
  • Jeremy Pena has recorded at least one hit in each of his last 17 appearances against NL East opponents.

Phillies vs Astros Prediction

Javier has been a mess this season with a 5.98 ERA and 1.55 WHIP, and he has a 6.65 ERA and a .313 allowed batting average in 23 innings on the road. Since August, the Astros are 1-5 with Javier on the mound. Wheeler was shaky at times in August, but he still has a 3.23 ERA and 1.08 WHIP on the season, and he has a .192 allowed batting average at home. Quick turnarounds also usually favor the home team. I have to back the Phillies with the clear edge on the mound, and of course I’ll lay the RL to shave down the price.

Randy Chambers's Free Pick: Philadelphia Phillies -1.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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