Phillies vs Guardians Prediction 5/22/26 MLB Picks Today

In this article we will formulate a Phillies vs Guardians prediction for this MLB game on Friday, May 22nd at Citizens Bank Park in Philadelphia, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 25-25 this year after they lost two out of three against the Reds by scores of 5-4, 1-4, and 4-9. In game three, Philadelphia led 1-0 in the first inning, but they allowed eight of the last eleven runs in the loss. The Phillies recorded six hits and they committed one error in the game, while they were led by Sosa, who went 1-3 with one home run and two RBIs. Nola allowed eight hits and four earned runs over 5.0 innings for the loss, while Alvarado allowed two earned runs in relief. Prior to that series, Philadelphia swept the Pirates in three games and won two out of three against the Red Sox. 

This season, Philadelphia has a 4.31 ERA with a 1.35 WHIP and a .265 opponent batting average, while they have scored 209 runs with a .231 batting average and a .300 on base percentage. Kyle Schwarber has led the Phillies with 20 home runs and 36 RBIs, while Bryce Harper has added 12 home runs and 31 RBIs. The projected starting pitcher for Philadelphia is Cristopher Sanchez, who is 5-2 with a 1.82 ERA and a 1.20 WHIP over 64.1 innings pitched this year. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 30-22 this season after they won all four games against the Tigers by scores of 8-2, 4-3, 3-2, and 3-1. In game four, Cleveland took a 2-0 lead in the third inning and never looked back in the win. The Guardians recorded six hits in the game and they were led by Bailey, who went 1-3 with one home run and one RBI. Cantillo allowed three hits and zero earned runs over 5.2 innings for the win, while Gaddis picked up the save. Prior to that series, Cleveland won two out of three against the Reds and all three against the Angels. 

This season, Cleveland has a 3.67 ERA with a 1.26 WHIP and a .234 opponent batting average, while they have scored 228 runs with a .230 batting average and a .324 on base percentage. Chase DeLauter has led the Guardians with seven home runs and 30 RBIs, while Jose Ramirez has added eight home runs and 24 RBIs. The projected starting pitcher for Cleveland is Gavin Williams, who is 6-3 with a 3.67 ERA and a 1.19 WHIP over 61.1 innings pitched this season. 

Why the Philadelphia Phillies will win

• The Phillies have won each of their last 10 games against American League opponents that held a winning record.
• The Guardians have lost each of their last eight night games against National League opponents following a win.
• The Phillies have covered the run line each of their last 10 games against American League opponents that held a winning record.
• The Guardians have failed to cover the run line in seven of their last eight night games against National League opponents following a win.
• The Phillies have led after 5 innings in six of their last seven games against American League opponents that held a winning record.
• The Phillies have won the first inning in five of their last six games as favorites.
• The Phillies have led after 3 innings in six of their last seven home games against American League opponents that held a winning record.

Why the Cleveland Guardians will win

• The Guardians have won each of their last nine games after playing the previous day.
• The Phillies have lost four of their last five games as favorites following a home loss.
• The road team has covered the run line in each of the Phillies’ last seven games.
• The Phillies have failed to cover the run line in seven of their last eight games following a home loss.
• The Phillies have lost the first inning in three of their last four night games against AL Central opponents.
• The Guardians have led after 3 innings in four of their last five games as underdogs.
• The Guardians have led after 5 innings in each of their last four games as underdogs.

Total Runs Facts

• Each of the last five games between the Guardians and Phillies at Citizens Bank Park have gone UNDER the total runs line.
• Each of the Guardians’ last five night games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last seven Friday games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last four night games between the Guardians and Phillies.

Philadelphia Phillies Player Prop Facts

• Kyle Schwarber has hit at least one home run in each of his last four home appearances.
• Alec Bohm has recorded at least one hit in each of the Phillies’ last 11 games.
• Kyle Schwarber ranks 1st in the league in Home Runs (20) this season.

Cleveland Guardians Player Prop Facts

• Rhys Hoskins has hit at least one home run in two of his last three appearances against the Phillies after playing the previous day.
• Steven Kwan has recorded at least one hit in 15 of his last 16 road appearances against NL East opponents.
• Jose Ramirez ranks 2nd in the league in Steals (20) this season.

Matchup/League Facts

• The Phillies rank 2nd in the league for strikeouts this season (476).
• The Phillies rank 29th in the league for opponent batting average this season (.265).
• The Guardians rank 1st in the league for strikeouts this season (484).
• The Guardians rank T2nd in the league for steals this season (54).

Phillies vs Guardians Prediction 

Cleveland comes into this matchup on a nice winning streak and they have allowed three runs or fewer in five straight games. The Guardians are 15-12 on the road this year, while the Phillies are 13-14 at home. Philadelphia has been red hot over the last few weeks, but they did lose two out of three against the Reds. The Phillies are starting Sanchez, who has allowed zero earned runs in three straight starts, while Williams has allowed 5+ earned runs in three of his last five outings. Take the Phillies -1.5 here.