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Phillies vs Red Sox Prediction 7-21-25 MLB Picks

Boston Red Sox (54-47) vs. Philadelphia Phillies (56-43)
July 21, 2025 10:45 pm EDT
The Line: Philadelphia Phillies -218 / Boston Red Sox 176; Over/Under: 8.5
(Get latest betting odds)

The Boston Red Sox and Philadelphia Phillies meet Monday in MLB action at Citizens Bank Park. Here’s a Phillies vs Red Sox Prediction. This article will include a Phillies vs Red Sox Pick.

Boston Red Sox Betting Preview

The Boston Red Sox are 54-47 on the year and play the Dodgers, Twins, and Astros next. The Boston Red Sox are batting .254 on the season, have a .325 OBP, and a .430 slugging percentage. The Boston Red Sox pitching staff has a 3.79 ERA and a 1.30 WHIP. Jarren Duran leads the Boston Red Sox with 104 hits and 50 RBI, while Trevor Story and Ceddanne Rafaela have combined for 181 hits and 106 RBI.

Walker Buehler gets the ball for the Boston Red Sox, and he is 6-6 with a 6.12 ERA and 63 strikeouts this season. Buehler is 1-1 with a 6.48 ERA and 17 strikeouts in his career against the Philadelphia Phillies.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies are 56-43 on the year and play the Yankees, White Sox, and Tigers next. The Philadelphia Phillies are batting .255 on the season, have a .328 OBP, and a .405 slugging percentage. The Philadelphia Phillies pitching staff has a 3.73 ERA and a 1.26 WHIP. Trea Turner leads the Philadelphia Phillies with 115 hits and 41 RBI, while Nick Castellanos and Alec Bohm have combined for 199 hits and 94 RBI.

Zack Wheeler gets the ball for the Philadelphia Phillies, and he is 9-3 with a 2.36 ERA and 154 strikeouts this season. Wheeler is 2-1 with a 2.75 ERA and 21 strikeouts in his career against the Boston Red Sox.

Why the Philadelphia Phillies will win

  • The favorites have won each of the Red Sox’s last 13 games.
  • The Red Sox have lost each of their last five road games against NL East opponents that held a winning record.
  • The Phillies have covered the run line in each of their last six games following a home loss.
  • The Red Sox have failed to cover the run line each of their last five road games against NL East opponents that held a winning record.
  • The Red Sox have lost the first inning in six of their last seven games as underdogs against National League opponents.
  • The Red Sox have trailed after 3 innings in each of their last 11 road games against National League opponents that held a winning record.
  • The Phillies have led after 5 innings in seven of their last eight night games against AL East opponents.

Why the Boston Red Sox will win

  • The Red Sox have won 11 of their last 12 games after playing the previous day.
  • The Phillies have lost three of their last four games as favorites against American League opponents.
  • The Phillies have failed to cover the run line in 12 of their last 13 home games against AL East opponents following a loss.
  • The Red Sox have covered the run line in seven of their last eight games against National League opponents after playing the previous day.
  • The Red Sox have led after 5 innings in each of their last four games against NL East opponents.
  • The Red Sox have won the first inning in three of their last four games against NL East opponents.
  • The Red Sox have led after 3 innings in each of their last four games against NL East opponents.

Philadelphia Phillies Player Prop Facts

  • Kyle Schwarber has hit a home run in each of the Phillies’ last four night games.
  • Zack Wheeler has recorded nine strikeouts in each of his last three appearances against AL East opponents.
  • Max Kepler has recorded at least one hit in each of his last 10 appearances against the Red Sox.
  • Bryce Harper has recorded a Double in four of the Phillies’ last five games.
  • Zack Wheeler has recorded a win in five of his last six appearances against AL opponents.
  • Trea Turner ranks 2nd in the league in Hits (115) this season.

Boston Red Sox Player Prop Facts

  • Alex Bregman has hit a home run in three of his last four road appearances after playing the previous day.
  • Ceddanne Rafaela has recorded at least one hit in each of his last eight appearances in night games.
  • Walker Buehler has recorded four or more strikeouts in nine of his last 10 appearances in night games against NL East teams that held a winning record.
  • Ceddanne Rafaela has recorded a Double in each of the Red Sox’s last three road games against NL East opponents.

Phillies vs Red Sox Prediction

The Red Sox and big plus money is worth a look because they’re a good baseball team, and you’re not going to get these prices often. However, Buehler has been a mess this season, with a 6.12 ERA and 1.56 WHIP on the season. In 35.1 road innings, Buehler has an 8.66 ERA and .342 allowed batting average. Yikes. Wheeler looks like a CY Young contender with a 2.36 ERA and 0.86 WHIP, and he has a 1.91 ERA and .164 allowed batting average in 66 home innings. In Wheeler’s last 46 innings overall, he’s allowed 27 hits and seven earned runs. Elite stuff, folks. Clear mismatch on the hill. Give me the Phillies and the RL for max betting value.

Randy Chambers's Free Pick: Philadelphia Phillies -1.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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