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Pirates vs Giants Prediction 8-6-25 MLB Picks

San Francisco Giants (57-57) vs. Pittsburgh Pirates (49-65)
August 6, 2025 12:35 pm EDT
The Line: Pittsburgh Pirates 127 / San Francisco Giants -155; Over/Under: 7.5
(Get latest betting odds)

The San Francisco Giants and Pittsburgh Pirates meet Wednesday in MLB action at PNC Park. Here’s a Pirates vs Giants Prediction. This article will include a Pirates vs Giants Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 57-57 on the year and play the Nationals, Padres, and Rays next. The San Francisco Giants are batting .234 on the season, have a .312 OBP, and a .377 slugging percentage. The San Francisco Giants pitching staff has a 3.67 ERA and a 1.28 WHIP. Heliot Ramos leads the San Francisco Giants with 119 hits and 51 RBI, while Jung Hoo Lee and Willy Adames have combined for 203 hits and 107 RBI.

Robbie Ray gets the ball for the San Francisco Giants, and he is 9-5 with a 2.85 ERA and 140 strikeouts this season. Ray is 2-2 with a 4.78 ERA and 33 strikeouts in his career against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 49-65 on the year and play the Reds, Brewers, and Cubs next. The Pittsburgh Pirates are batting .232 on the season, have a .303 OBP, and a .347 slugging percentage. The Pittsburgh Pirates pitching staff has a 3.88 ERA and a 1.22 WHIP. Bryan Reynolds leads the Pittsburgh Pirates with 100 hits and 53 RBI while Isiah Kiner-Falefa and Andrew McCutchen have combined for 177 hits and 69 RBI.

Andrew Heaney gets the ball for the Pittsburgh Pirates, and he is 6-9 with a 4.89 ERA and 79 strikeouts this season. Heaney is 1-4 with a 5.84 ERA and 52 strikeouts in his career against the San Francisco Giants.

Why the Pittsburgh Pirates will win

  • The underdogs have won nine of the last 10 games between the Giants and Pirates.
  • The Giants have lost seven of their last eight games as favorites.
  • The Pirates have covered the run line in each of their last 11 Wednesday games as home underdogs.
  • The Giants have failed to cover the run line in nine of their last 10 games as favorites.
  • The Pirates have led after 3 innings in six of their last seven day games against National League opponents.
  • The Pirates have led after 5 innings in each of their last five day games at PNC Park against National League opponents.

Why the San Francisco Giants will win

  • The Pirates have lost nine of their last 10 day games against the Giants following a loss.
  • The Giants have won eight of their last nine day games against the Pirates following a win.
  • The Pirates have failed to cover the run line in seven of their last eight day games against the Giants at PNC Park following a home loss.
  • The Giants have covered the run line in each of their last five day games against NL Central opponents following a road win.
  • The Giants have led after 3 innings in each of their last four road games against NL Central opponents.
  • The Giants have led after 5 innings in each of their last four road games against National League opponents that held a losing record.

Pittsburgh Pirates Player Prop Facts

  • Bryan Reynolds has hit a home run in three of his last seven appearances against the Giants after playing the previous day.
  • Andrew Heaney has recorded five or more strikeouts in seven of his eight previous appearances against the Giants.
  • Tommy Pham has recorded at least one hit in each of his last nine appearances in day games.
  • Andrew Heaney has recorded a win in three of his last four home appearances against NL opponents.
  • Oneil Cruz ranks 2nd in the league in Steals (34) this season.

San Francisco Giants Player Prop Facts

  • Jung Hoo Lee has recorded a Double in four of the Giants’ last five games against NL opponents.
  • Dominic Smith has recorded at least one hit in each of his last 10 appearances.
  • Tom Murphy has hit a home run in three of his four previous appearances against the Pirates.

Pirates vs Giants Prediction

The Giants have been a complete mess in the second half and aren’t a team I’m excited to back, but they should win with Ray on the mound. Ray has a 2.85 ERA and 1.12 WHIP on the season and has allowed 13 runs in his last 37.2 innings. Heaney has allowed 27 hits and 17 earned runs in his last 17.1 innings. There are no excuses for the Giants in this spot, given the clear edge on the mound. Give me the Giants.

Randy Chambers's Free Pick: San Francisco Giants -155

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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