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Pirates vs Tigers Prediction 9/25/26 MLB Picks Today

Pittsburgh Pirates (81-78) vs. Detroit Tigers (74-85)
September 25, 2026 6:40 pm EDT
The Line: Detroit Tigers -110 / Pittsburgh Pirates -109; Over/Under: 8
(Get latest betting odds)

In this article, we will formulate a Pirates vs Tigers Prediction for this MLB matchup on Friday, September 25th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Detroit Tigers Preview

The Detroit Tigers have a 74-85 record this season and are sitting in the 4th place of the AL Central. They have a 40-38 home record and are coming off a 2-4 home loss against the Nationals.

The Detroit Tigers have a .241 batting average this season, .320 OBP and .400 Slugging percentage. Detroit’s pitching staff has a 3.65 ERA and 1.22 WHIP. Riley Greene is the team’s best hitter with a .282 batting average. Dillon Dingler leads the team in RBI with 89, adding a team-high 27 home runs.

Jackson Jobe (R) is the projected starting pitcher for the Tigers, and he has a 2-3 record, 3.98 ERA and 1.20 WHIP.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 81-78 record this season and are sitting in the 3rd place of the NL Central. They have a 37-41 away record and are coming off a 2-1 home win against the Cardinals.

The Pittsburgh Pirates have a .253 batting average this season, .331 OBP and .404 Slugging percentage. Pittsburgh’s pitching staff has a 4.15 ERA and 1.30 WHIP. Nick Gonzales is the team’s best hitter with a .301 batting average. Brandon Lowe leads the team in RBI with 95, adding a team-high 34 home runs.

Bubba Chandler (R) is the projected starting pitcher for the Pirates, and he has a 8-9 record, 4.34 ERA and 1.37 WHIP.

Pittsburgh Pirates @ Detroit Tigers Betting Trends: September 25, 2026

 

  • Probable Starting Pitcher: Jackson Jobe      Record this season: 2-3      ERA: 3.98
  • Home Record: 1-1
  • Last 5 against Pirates: 0-0

Why the Detroit Tigers will win

  • The Pirates have lost each of their last nine Friday road games.
  • The Tigers have won each of their last four night games against NL Central opponents following a home loss.
  • The Tigers have covered the run line in each of their last six night games against NL opponents following a loss.
  • The Pirates have failed to cover the run line in each of their last four games after playing the previous day.
  • The Pirates have trailed after 5 innings in each of their last nine Friday road games.
  • The Tigers have led after 3 innings in four of their last five games as favorites against NL Central opponents.

 

  • Probable Starting Pitcher: Bubba Chandler      Record this season: 8-9      ERA: 4.34
  • Road Record: 4-6
  • Last 5 against Tigers: –

Why the Pittsburgh Pirates will win

  • The Pirates have won each of their last eight games against AL Central opponents.
  • The Tigers have lost five of their last six games as home favorites against NL opponents following a home loss.
  • The Pirates have covered the run line in seven of their last eight games as underdogs after playing the previous day.
  • The Tigers have failed to cover the run line in four of their last five games.
  • The Tigers have trailed after 3 innings in each of their last four games against opponents that held a winning record.
  • The Tigers have lost the first inning in three of their last four games against opponents that held a winning record.
  • The Pirates have led after 5 innings in each of their last six road games against AL Central opponents.

Total Runs Facts

  • Each of the last six games between the Pirates and Tigers at Comerica Park have gone OVER the total runs line.
  • Seven of the Pirates’ last eight games as underdogs against the Tigers have gone OVER the total runs line.
  • There has been no run scored during the first inning in 10 of the Pirates’ last 11 road games against AL Central opponents.
  • There has been at least one run scored in the first inning in seven of the Tigers’ last eight games against NL Central opponents.

Detroit Tigers Player Prop Facts

  • Spencer Torkelson has hit a home run in five of the Tigers’ last six games as favorites against NL Central opponents.
  • Jackson Jobe has recorded seven or more strikeouts in each of his last three appearances.
  • Kevin McGonigle has recorded at least one hit in each of the Tigers’ last 12 games against NL Central opponents.

Pittsburgh Pirates Player Prop Facts

  • Brandon Lowe has hit a home run in five of the Pirates’ last six night games.
  • Bubba Chandler has recorded a win in four of his last five appearances with the Pirates as underdogs against AL opponents.
  • Bubba Chandler has recorded five or more strikeouts in each of his last four appearances against AL opponents.
  • Oneil Cruz has recorded at least one hit in each of his last 13 appearances with the Pirates as underdogs against AL Central opponents.
  • Nick Gonzales is one of only five players to hit over .300 and have 45+ RBIs this season.

Matchup/League Facts

  • The Tigers rank 29th in the league for steals this season (56).
  • The Tigers rank 4th in the league for triples this season (33).
  • The Pirates rank T1st in the league for home runs allowed this season (151).
  • The Pirates rank 2nd in the league for hits this season (1381).

Pirates vs Tigers Prediction

The Pirates are 6-1 in their last 7 meetings against the Tigers but have lost two of their last three visits in Detroit.

In this Pirates vs Tigers Prediction, both teams are coming at a pickem price. Both teams have nothing to play for so I will go with the team in better form, which is the Pirates, who are 6-1 in their last 7 games. The Tigers are 2-6 in their last 8 and have scored just one run in five of their last eight games and Jobe has been bad at home with a 5.02 ERA. Take the Pirates to win this one on the road.

Nikos Lagouretos's Free Pick: Pittsburgh Pirates ML

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