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Pirates vs Yankees Prediction 4/4/25 MLB Picks Today

NY Yankees (4-2) vs. Pittsburgh Pirates (2-5)
April 4, 2025 4:12 pm EDT
The Line: Pittsburgh Pirates 140 / NY Yankees -166; Over/Under: 8
(Get latest betting odds)

The New York Yankees and Pittsburgh Pirates meet Friday in MLB action at PNC Park. Here’s a Pirates vs Yankees Prediction. This article will include a Pirates vs Yankees Pick.

New York Yankees Betting Preview

The New York Yankees are 4-2 on the year and play the Tigers, Giants, and Royals next. The New York Yankees are batting .278 on the season, have a .357 OBP, and a .649 slugging percentage. The New York Yankees pitching staff has a 4.67 ERA and a 1.28 WHIP. Aaron Judge leads the New York Yankees with 10 hits and 15 RBI, while Jazz Chisholm Jr. and Ben Rice have combined for 13 hits and 10 RBI.

Max Fried gets the ball for the New York Yankees, and he is 0-0 with a 3.86 ERA and 4 strikeouts this season. Fried is 3-1 with a 4.28 ERA and 33 strikeouts in his career against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 4-2 on the year and play the Cardinals, Reds, and Nationals next. The Pittsburgh Pirates are batting .197 on the season, have a .291 OBP, and a .278 slugging percentage. The Pittsburgh Pirates pitching staff has a 3.96 ERA and a 1.40 WHIP. Isiah Kiner-Falefa leads the Pittsburgh Pirates with 7 hits and 1 RBI while Bryan Reynolds and Oneil Cruz have combined for 12 hits and 6 RBI.

Mitch Keller gets the ball for the Pittsburgh Pirates, and he is 1-0 with a 1.50 ERA and 4 strikeouts this season. This will be Keller’s second career game against the New York Yankees.

Why the Pittsburgh Pirates will win

  • The Yankees have lost each of their last three road openers as favorites.
  • The Pirates have won three of their last four games as underdogs against the Yankees.
  • The Yankees have failed to cover the run line in four of their last five road games against National League opponents that held a losing record.
  • The Pirates have covered the run line in nine of their last 11 games against American League opponents following a road win.
  • The Yankees have trailed after 3 innings in five of their last six road games against National League opponents that held a losing record.
  • The Pirates have led after 5 innings in eight of their last 10 home openers.

Why the New York Yankees will win

  • The Yankees have won each of their last nine games as road favorites.
  • The Pirates have lost seven of their last eight games following a win.
  • The Yankees have covered the run line in each of their last six games as road favorites after playing the previous day.
  • The Pirates have failed to cover the run line in each of their last six home games against AL East opponents.
  • The Pirates have trailed after 3 innings in each of their last seven Friday day games as underdogs.
  • The Yankees have won the first inning in each of their last four games against NL Central opponents.
  • The Yankees have led after 5 innings in five of their last six games.

Pirates vs Yankees Prediction

The Pirates will be up for this series as their first home games of the season, and Keller is a pitcher who is worth taking a look at in the underdog role. However, the Pirates have been one of the worst offensive teams in baseball through seven games, and that’s not ideal when going up against the Yankees. The Yankees are crushing the baseball and have scored four or more runs in five of their first six games.

You need to score to compete against the Yankees this season, and the Pirates haven’t shown they can do that yet, and keep in mind four of their games came against the Marlins. This series will get ugly if the Pirates don’t pick things up. Give me the Yankees and the RL for max betting value.

Randy Chambers's Free Pick: NY Yankees -1.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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