Rays vs Blue Jays Prediction 9/16/25 MLB Picks Today

In this article we will formulate a Rays vs Blue Jays prediction for this MLB game on Tuesday, September 16th at George M. Steinbrenner Field in Tampa, Florida. Let’s take a look at the prediction for this MLB matchup. 

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 73-77 this year after they lost game one by a score of 2-1 on Monday night. Tampa Bay led 1-0 in the first inning, but they went scoreless over the last 10 innings for the loss. The Rays recorded four hits and they committed one error in the game, while they were led by Diaz, who went 3-3 with one RBI in the loss. Tampa Bay started Boyle, who allowed three hits and zero earned runs over 6.0 innings, while Kelly picked up the loss in extra innings. 

Prior to this series, the Rays lost two out of three against the Cubs and two out of three against the White Sox. Tampa Bay has lost five of their last six games and they are fourth in the AL East standings. The Tampa Bay pitching staff has a 3.88 ERA with a 1.21 WHIP and a .236 opponent batting average, while the offense has scored 668 runs with a .251 batting average and a .312 on base percentage this season. Junior Caminero has led Tampa Bay with 44 home runs and 108 RBIs, while Brandon Lowe has added 28 home runs and 75 RBIs for the Rays this year. The projected starting pitcher for Tampa Bay is Ryan Pepiot, who is 11-10 with a 3.59 ERA and a 1.13 WHIP over 163.0 innings pitched this year. 

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 88-62 this season after they won game one in extra innings by a score of 2-1 on Monday. Toronto tied the game at one in the eighth inning and held TB scoreless in the 10th and 11th for the victory. The Blue Jays recorded five hits in the game and they were led by Gimenez and Springer, who both had one RBI in the win. Toronto started Yesavage, who allowed three hits and one earned run over 5.0 innings, while Fisher got the win. 

Prior to this series, the Blue Jays won all three against the Orioles and two out of three against the Astros. Toronto has won five games in a row and they are currently first in the AL East standings. The Toronto pitching staff has a 4.13 ERA with a 1.25 WHIP and a .238 opponent batting average, while their offense has scored 751 runs with a .269 batting average and a .337 on base percentage this season. Vladimir Guerrero Jr. has led Toronto with 23 home runs and 80 RBIs, while George Springer has added 29 home runs and 76 RBIs this year. The projected starting pitcher for Toronto is Jose Berrios, who is 9-5 with a 3.99 ERA and a 1.29 WHIP over 160.0 innings pitched this season. 

Why the Rays will beat the Blue Jays

• The Blue Jays have lost 19 of their last 21 road games against the Rays following a road win.
• The Rays have won eight of their last nine home games following an extra innings loss.
• The Blue Jays have failed to cover the run line in each of their last nine games against the Rays following a win.
• The Rays have covered the run line in each of their last seven night games against the Blue Jays following a loss.
• The Rays have led after 5 innings in each of their last seven games against the Blue Jays.
• The Rays have led after 3 innings in each of their last five games against the Blue Jays.
• The Rays have won the first inning in four of their last five games against the Blue Jays.

Why the Blue Jays will beat the Rays

• The Blue Jays have won seven of their last eight games as underdogs against AL East opponents following a win.
• The Rays have lost each of their last six games against AL East opponents.
• The Rays have failed to cover the run line in each of their last nine games against American League opponents following a home loss.
• The underdogs have covered the run line in nine of the Rays’ last 10 games.
• The Rays have lost the first inning in each of their last four games as favorites against AL East opponents.
• The Rays have trailed after 5 innings in each of their last four games as favorites against AL East opponents.
• The Rays have trailed after 3 innings in each of their last four games as favorites against AL East opponents.

Total Runs Facts

• Each of the Blue Jays’ last five night games against American League opponents have gone UNDER the total runs line.
• Four of the Rays’ last five home games have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Rays’ last six home games against AL East opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Blue Jays’ last nine games as road underdogs against AL East opponents.

Rays vs Blue Jays Prediction 

Toronto was able to escape with a low scoring win on Monday and they have extended their lead in the AL East to five games. The Jays are 38-37 on the road this year, while the Rays are 38-37 at home. Tampa Bay continues their slide and they are just three games ahead of Baltimore for fourth in the East. The Rays are starting Pepiot, who has allowed zero earned runs in three straight outings. The Blue Jays are going with Berrios, who has allowed two earned runs or fewer in four of his last five starts. Take the under in this matchup.