Rays vs White Sox Prediction 7/21/25 MLB Picks Today

In this article we will formulate a Rays vs White Sox prediction for this MLB game on Monday, July 21st at George M. Steinbrenner Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 52-48 this season after they won two out of three against Baltimore by scores of 11-1, 4-3, and 3-5. In their game three loss, Tampa Bay cut the deficit to 4-2 in the fourth inning, but only scored one run in the final five innings for the loss. The Rays recorded seven hits in the game and they were led by Walls, Jansen, and Caminero, who all had one RBI in the loss. TB started Pepiot, who allowed six hits and five earned runs over 6.0 innings for the loss, while Seymour pitched two scoreless innings in relief. 

Prior to that series, the Rays lost all four against the Red Sox and two out of three against the Tigers. Tampa Bay has lost five of their last seven games and they are currently fourth in the AL East standings. The Tampa Bay pitching staff has a 3.75 ERA with a 1.20 WHIP and a .237 opponent batting average, while the offense has scored 467 runs with a .258 batting average and a .320 on base percentage this season. Junior Caminero has led Tampa Bay with 25 home runs and 65 RBIs, while Brandon Lowe has added 19 home runs and 50 RBIs for the Rays this year. The projected starting pitcher for Tampa Bay is Shane Baz, who is 8-5 with a 4.17 ERA and a 1.25 WHIP over 110.0 innings pitched this season. 

Chicago White Sox Betting Preview

The Chicago White Sox are 35-65 this year after they swept the Pirates in three games by scores of 10-1, 10-4, and 7-2. In their game three win, Chicago scored four runs in the first inning and won comfortably for the sweep. The White Sox recorded 10 hits and they committed one error in the game, while they were led by Vargas and Tauchman, who both had three RBIs in the win. Chicago started Civale, who allowed three hits and zero earned runs over 6.0 innings for the win, while Vasil allowed one earned run in relief. 

Prior to that series, the White Sox lost three out of four against the Guardians and two out of three against the Blue Jays. Chicago has won four of their last six games and they are currently last in the AL Central standings. The Chicago pitching staff has a 4.07 ERA with a 1.37 WHIP and a .251 opponent batting average, while the offense has scored 359 runs with a .223 batting average and a .298 on base percentage this season. Miguel Vargas has led Chicago with 11 home runs and 38 RBIs, while Andrew Benintendi has added 11 home runs and 37 RBIs this year. The projected starting pitcher for Chicago is Sean Burke, who is 4-8 with a 4.36 ERA and a 1.40 WHIP over 97.0 innings pitched this year. 

Why the White Sox will beat the Rays

• The White Sox have won each of their last four games as road underdogs.
• The Rays have lost five of their last seven games as favorites after playing the previous day.
• The Rays have failed to cover the run line in each of their last seven games as favorites after playing the previous day.
• The White Sox have covered the run line in each of their last four games.
• The Rays have trailed after 3 innings in four of their last five games as favorites against American League opponents.
• The Rays have trailed after 5 innings in four of their last five games as favorites against American League opponents.
• The Rays have lost the first inning in three of their last four home games against American League opponents that held a losing record.

Total Runs Facts

• Each of the White Sox’s last seven road games against AL East opponents have gone UNDER the total runs line.
• Each of the Rays’ last four games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last six games between the White Sox and Rays.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the White Sox’s last four games as underdogs against AL East opponents.

Tampa Bay Rays Player Prop Facts

• Danny Jansen has hit a home run in four of his last five home appearances with the Rays against AL opponents.
• Yandy Diaz has recorded at least one hit in 23 of his last 24 appearances in night games against teams that held a losing record.

Chicago White Sox Player Prop Facts

• Michael A. Taylor has recorded a Double in each of his last four appearances with the White Sox as road underdogs.
• Luis Robert has hit a home run in three of his last seven appearances in night games.
• Luis Robert has recorded at least one hit in each of the White Sox’s last seven games as underdogs.

Matchup/League Facts

• The Rays rank 1st in the league for steals this season (129).
• The Rays rank 3rd in the league for batting average this season (.258).
• The White Sox rank 30th in the league for batting average this season (.223).
• The White Sox rank 29th in the league for hits this season (728).

Rays vs White Sox Prediction 

Chicago comes into this matchup with plenty of confidence after picking up a rare sweep over the weekend, but they are still one of the worst road teams in the MLB. The White Sox are 14-36 on the road this season, while the Rays are 30-26 at home. Tampa Bay continues to have some struggles and they are starting Baz, who has allowed at least three earned runs in three of his last five starts. The White Sox are going with Burke, who has allowed two earned runs or fewer in four of his last five outings. I know it isn’t a great idea, but I am going to ride Chicago with Burke on the mound here.