Red Sox vs Athletics Prediction 9/16/25 MLB Picks Today

The Athletics and Boston Red Sox meet Tuesday in MLB action at Fenway Park. Here’s a Red Sox vs Athletics Prediction. This article will include a Red Sox vs Athletics Pick.

Athletics Betting Preview

The Athletics are 70-80 on the year and play the Pirates, Astros, and Royals next. The Athletics are batting .255 on the season, have a .321 OBP, and a .438 slugging percentage. The Athletics pitching staff has a 4.77 ERA and a 1.36 WHIP. Brent Rooker leads the Athletics with 158 hits and 85 RBI, while Tyler Soderstrom and Jacob Wilson have combined for 286 hits and 147 RBI.

Jeffrey Springs gets the ball for the Athletics, and he is 10-11 with a 4.28 ERA and 132 strikeouts this season. Springs is 0-3 with a 4.55 ERA and 38 strikeouts in his career against the Boston Red Sox.

Boston Red Sox Betting Preview

The Boston Red Sox are 82-68 on the year and play the Rays, Blue Jays, and Tigers next. The Boston Red Sox are batting .254 on the season, have a .324 OBP, and a .425 slugging percentage. The Boston Red Sox pitching staff has a 3.74 ERA and a 1.29 WHIP. Jarren Duran leads the Boston Red Sox with 148 hits and 80 RBI while Trevor Story and Ceddanne Rafaela have combined for 267 hits and 151 RBI.

Connelly Early gets the ball for the Boston Red Sox, and he is 1-0 with a 0.00 ERA and 11 strikeouts this season. This will be Early’s second career game against the Athletics.

Athletics @ Boston Red Sox Betting Trends: September 16, 2025

• Probable Starting Pitcher: Connelly Early      Record this season: 1-0      ERA: 0.00
• Home Record: 0-0
• Last 5 against Athletics: 1-0

Why the Boston Red Sox will win

• The Athletics have lost nine of their last 10 night games against AL East opponents following a home win.
• The home team has won each of the Athletics’ last four games.
• The home team has covered the run line in each of the Athletics’ last four games.
• The Athletics have failed to cover the run line each of their last four night games against American League opponents that held a winning record.
• The Red Sox have won the first inning in six of their last seven night games against the Athletics.
• The Red Sox have led after 3 innings in each of their last seven Tuesday games.
• The Athletics have trailed after 5 innings in each of their last four night games against American League opponents that held a winning record.

• Probable Starting Pitcher: Jeffrey Springs      Record this season: 10-11      ERA: 4.28
• Road Record: 5-6
• Last 5 against Red Sox: 0-3

Why the Athletics will win

• The Athletics have won each of their last five games as underdogs following a win.
• The Red Sox have lost four of their last six games as favorites.
• The Athletics have covered the run line in 16 of their last 17 games as road underdogs.
• The Red Sox have failed to cover the run line each of their last four home games against American League opponents that held a losing record.
• The Red Sox have lost the first inning in three of their last four games.
• The Red Sox have trailed after 3 innings in four of their last five home games against AL West opponents that held a losing record.
• The Red Sox have trailed after 5 innings in each of their last six night games at Fenway Park against AL West opponents.

Total Runs Facts

• Each of the last five games between the Athletics and Red Sox have gone UNDER the total runs line.
• Each of the Athletics’ last four games as underdogs against the Red Sox have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Athletics’ last seven games against American League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last seven games against American League opponents.

Boston Red Sox Player Prop Facts

• Alex Bregman has recorded at least one hit in each of his last 11 appearances after not playing the previous day.
• Triston Casas has hit a home run in four of his last five home appearances against AL West opponents.
• Jarren Duran has recorded at least one Double in each of the Red Sox’s last six night games against AL West opponents that held a losing record.

Athletics Player Prop Facts

• Nick Kurtz has hit a home run in four of the Athletics’ last five games as underdogs.
• Lawrence Butler has recorded at least one hit in each of his last eight appearances against opponents that held a winning record.
• Nick Kurtz has recorded at least one Double in three of his last four road appearances after not playing the previous day.
• Jacob Wilson ranks 2nd amongst qualified players for Batting Average (.318) this season.

Matchup/League Facts

• The Red Sox rank 1st in the league for doubles this season (302).
• The Red Sox are one of only four teams in the league to rank top 10 in both steals and batting average this season.
• The Athletics rank 29th in the league for home runs allowed this season (210).
• The Athletics rank 3rd in the league for doubles this season (275).

Red Sox vs Athletics Prediction

The Athletics have put together some nice wins lately, but they’re still not a team I’m running to back with just two weeks left in the season. Springs also isn’t off to a great September, allowing 13 hits and 7 runs in 11 innings. The Red Sox need to take advantage of games like this in terms of playoff positioning, and Early just shutout the A’s through 5 innings while striking out 11. I’m sure the Athletics will have some sort of success seeing Early again, but I’m still siding with the Red Sox on Tuesday night.