Red Sox vs Blue Jays Prediction 4/28/26 MLB Picks Today

In this article, we will formulate a Red Sox vs Blue Jays Prediction for this MLB matchup on Tuesday, April 28^th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Toronto Blue Jays Preview

The Toronto Blue Jays have a 12-16 record this season and are sitting in the fourth place of the AL East. They have a 8-8 home record and are coming off a 0-5 home defeat by the Red Sox. Their previous three games were a 4-2 win, a 5-3 win and an 8-6 loss at home against the Guardians.

The Blue Jays have a .249 batting average this season, .308 OBP and .379 Slugging percentage. Toronto’s pitching staff has a 4.47 ERA and 1.33 WHIP. Vladimir Guerrero Jr. is the team’s best hitter with a .330 batting average. Andres Gimenez leads the team in RBI with 16, and Kazuma Okamoto adds a team‑high 5 home runs.

Trey Yesavage (R) is the projected starting pitcher for the Blue Jays and last season he had 1-0 record, 3.21 ERA and a 1.43 WHIP.

Boston Red Sox Preview

The Boston Red Sox have a 12-17 record this season and are sitting in the fifth place of the AL East. They have a 7-9 away record and are coming off a 5-0 road win against the Blue Jays. Their previous three games were a 5-3 win, a 17-1 win and a 3-10 loss on the road against the Orioles.

The Red Sox have a .234 batting average this season, .314 OBP and .356 Slugging percentage. Boston’s pitching staff has a 4.23 ERA and 1.30 WHIP. Wilyer Abreu is the team’s best hitter with a .306 batting average. Willson Contreras leads the team in RBI with 19, also adding a team‑high 6 home runs.

Payton Tolle (L) is the projected starting pitcher for the Red Sox, and he has a 0-0 record, 1.50 ERA and 0.67 WHIP.

Boston Red Sox @ Toronto Blue Jays Betting Trends: April 28, 2026

• Probable Starting Pitcher: Trey Yesavage      Record this season: –      ERA: –
• Home Record: –
• Last 5 against Red Sox: –

Why the Toronto Blue Jays will win

• The Blue Jays have won nine of their last 10 home games against American League opponents that held a losing record.
• The Red Sox have lost six of their last seven night games against AL East opponents.
• The Red Sox have failed to cover the run line in 10 of their last 11 night games against American League opponents.
• The Blue Jays have covered the run line in each of their last four games as home favorites against AL East opponents following a loss.
• The Blue Jays have led after 5 innings in six of their last seven home games against American League opponents that held a losing record.
• The Blue Jays have won the first inning in three of their last four night games against AL East opponents.
• The Blue Jays have led after 3 innings in four of their last five home games against AL East opponents.

• Probable Starting Pitcher: Payton Tolle      Record this season: 0-0      ERA: 1.50
• Road Record: 0-0
• Last 5 against Blue Jays: 0-0

Why the Boston Red Sox will win

• The Blue Jays have lost each of their last six Tuesday games as favorites against AL East opponents.
• The Red Sox have won each of their last six Tuesday games as underdogs against AL East opponents.
• The Blue Jays have failed to cover the run line in each of their last 12 Tuesday games as favorites against AL East opponents.
• The Red Sox have covered the run line in each of their last six Tuesday road games against AL East opponents.
• The Red Sox have led after 5 innings in each of their last four games at Rogers Centre against opponents that held a losing record.
• The Red Sox have led after 3 innings in each of their last seven Tuesday games against American League opponents that held a losing record.

Total Runs Facts

• Eight of the Red Sox’s last nine night games against AL East opponents have gone UNDER the total runs line.
• Each of the Blue Jays’ last four night games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in 11 of the Red Sox’s last 13 games as road underdogs against AL East opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in 10 of the Blue Jays’ last 12 games as favorites.

Toronto Blue Jays Player Prop Facts

• Alejandro Kirk has hit at least one home run in each of his last three appearances with the Blue Jays as favorites against AL East opponents.
• George Springer has recorded at least one hit in each of his last 14 appearances in night games against teams that held a losing record.
• Ernie Clement ranks T3rd in the league in Hits (36) this season.

Boston Red Sox Player Prop Facts

• Willson Contreras has hit a home run in two of the Red Sox’s last three games.
• Isiah Kiner-Falefa has recorded at least one hit in each of his 13 previous appearances with his team as a road underdog against the Blue Jays.

Matchup/League Facts

• The Blue Jays rank 1st in the league for strikeouts against this season (198).
• The Blue Jays rank 2nd in the league for strikeouts this season (273).
• The Red Sox rank 28th in the league for slugging percentage this season (.356).
• The Red Sox rank 28th in the league for home runs allowed this season (39).

Red Sox vs Blue Jays Prediction

The Red Sox are 3-1 in their last 4 meetings against the Blue Jays and both teams are tied 3-3 in their last 6 meetings in Toronto.

In this Red Sox vs Blue Jays Prediction, the Blue Jays are coming as -120 home favorites. Boston kept rolling and shut out the Jays yesterday by 5-0 and are putting Payton Tolle on the mound, whose first start of the season was a quality start against the Yankees. I don’t trust Yesavage in his first start of the season for the Jays and the Red Sox have a better bullpen and a better offense, with the Jays being weaker against left-handed pitching. Give me the Red Sox and the plus money in this one.