Red Sox vs Cardinals Prediction 4/4/25 MLB Picks Today

In this article we will formulate a Red Sox vs Cardinals prediction for this MLB game on Friday, April 4th at Fenway Park in Boston, Massachusetts. Let’s take a look at the prediction for this MLB matchup. 

Boston Red Sox Betting Preview

The Boston Red Sox are 3-4 this season after they won two out of three against Baltimore in their last series. Boston lost game one in the series by a score of 8-5, but they did win games two and three by scores of 3-0 and 8-4. In their last game, the Red Sox scored in five of the nine innings and were able to cruise to the win after pulling away in the seventh. Boston recorded 11 hits in the game and they were led by Bregman, who went 3-5 with one home run and three RBI’s in the win. The Red Sox started Houck, who allowed five hits and three earned runs over 4.0 innings of work, while Whitlock allowed one earned run and one hit over the final two innings. 

Prior to that series, the Red Sox lost three out of four against the Rangers by scores of 5-2, 1-4, 3-4, and 2-3. The Boston pitching staff has a 3.81 ERA with a 1.19 WHIP and a .258 opponent batting average, while their offense has scored 27 runs with a .229 batting average and a .303 on base percentage this season. Wilyer Abreu has led Boston with two home runs and six RBIs, while Kristian Campbell has added two home runs and four RBIs this year. The projected starting pitcher for Boston is Walker Buehler, who is 0-1 with an 8.31 ERA and a 1.62 WHIP over 4.1 innings pitched this year. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 4-2 this year after they lost two out of three against the Angels in their last series. St. Louis lost games one and two by scores of 5-4 and 9-7, but did win game three by a score of 12-5 to avoid the sweep. In game three, the Cardinals trailed 5-3 in the seventh inning, but they scored seven runs in the eighth to get the big win. St. Louis recorded 12 hits in the game and they were led by Herrera, who went 3-4 with three home runs and six RBIs in the win. The Cardinals started Gray, who allowed five hits and five earned runs over 6.0 innings, while Romero pitched the final 1.1 innings for the win. 

Prior to that series, the Cardinals swept the Twins by scores of 5-3, 5-1, and 9-2. The St. Louis pitching staff has a 3.47 ERA with a 0.86 WHIP and a .181 opponent batting average, while their offense has scored 42 runs with a .298 batting average and a .381 on base percentage this season. Ivan Herrera has led St. Louis with three home runs and eight RBIs, while Lars Nootbaar has added two home runs and five RBIs this year. The projected starting pitcher for St. Louis Erick Fedde, who is 1-0 with a 1.50 ERA and a 0.33 WHIP over 6.0 innings pitched this season. 

Why the Red Sox will beat the Cardinals

• The Cardinals have lost each of their last seven day games against AL East opponents that held a losing record.
• The Red Sox have won eight of their last nine day games against NL Central opponents.
• The Red Sox have covered the run line each of their last four games against teams that held a winning record.
• The Cardinals have failed to cover the run line in four of their last five road openers.
• The Cardinals have trailed after 3 innings in six of their last seven road openers.
• The Cardinals have trailed after 5 innings in eight of their last nine road openers.

Why the Cardinals will beat the Red Sox

• The Red Sox have lost each of their last nine games against National League opponents that held a winning record.
• The Cardinals have won seven of their last eight games as underdogs.
• The Cardinals have covered the run line in each of their last nine games as underdogs.
• The Red Sox have failed to cover the run line in each of their last eight home games against NL Central opponents following a win.
• The Red Sox have trailed after 5 innings in six of their last seven games against National League opponents that held a winning record.
• The Red Sox have trailed after 3 innings in four of their last five games as favorites against NL Central opponents.

Total Runs Facts

• Eight of the last nine games between the Cardinals and Red Sox have gone OVER the total runs line.
• Each of the Cardinals’ last four games have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last six day games against AL East opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Red Sox’s last nine games as favorites.

Boston Red Sox Player Prop Facts

• Triston Casas has hit a home run in four of his last five appearances against NL Central opponents.
• Walker Buehler has recorded a win in nine of his last 12 appearances in day games.
• Rafael Devers has recorded at least one RBI in each of the Red Sox’s last six games against the Cardinals.
• Alex Bregman has scored at least one run in each of his last eight appearances at Fenway Park against opponents that held a winning record.
• Walker Buehler has recorded six or more strikeouts in seven of his last eight home appearances against NL Central opponents that held a winning record.
• Trevor Story has recorded a Single in each of his last five home appearances after playing the previous day.
• Trevor Story has recorded at least one hit in each of his last eight home appearances against NL Central opponents that held a winning record.
• Masataka Yoshida has recorded a Double in three of his last four appearances with the Red Sox as favorites against NL opponents.
• Wilyer Abreu ranks 1st amongst qualified players for Batting Average (.471) this season.

St. Louis Cardinals Player Prop Facts

• Nolan Arenado has hit a home run in five of the Cardinals’ last six road games against the Red Sox.
• Masyn Winn has recorded a Double in four of his last five road appearances against opponents that held a losing record.
• Nolan Arenado has recorded at least one RBI in each of his last four appearances against the Red Sox after not playing the previous day.
• Nolan Arenado has scored a run in each of his last six appearances with the Cardinals as underdogs.
• Nolan Arenado has recorded at least one Single in each of his last six appearances after not playing the previous day.
• Erick Fedde has recorded six or more strikeouts in three of his last four appearances against AL East opponents.
• Nolan Arenado has recorded at least one hit in each of his last 12 appearances.
• Victor Scott II ranks T3rd in the league in Steals (4) this season.

Red Sox vs Cardinals Prediction 

St. Louis comes into this matchup with one of the higher scoring offenses in the MLB and they are hitting nearly .300 as a team right now. Boston did win their last two games against Baltimore, but they are starting Buehler, who was not good in his first outing. The Cardinals are going with Fedde on the mound, who pitched well last time out, but I think he is going to struggle against this Boston lineup at Fenway. Take the over here.