Red Sox vs Diamondbacks Prediction 9/6/25 MLB Picks Today

In this article, we will formulate a Red Sox vs Diamondbacks Prediction for this MLB game on Saturday, September 6^th at the Chase Field in the second game of this series, with the Dbacks having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 71-71 record this season and are sitting on the 4^th place of the NL West. The Diamondbacks have a 37-33 home record and are 67-66 in over/under They are coming off a 10-5 home victory over the Red Sox, and are 7-2 in their last 9 games. Under is 5-3-1 in their last 9 games and are playing the Twins and the Giants next.

The Diamondbacks have a .250 batting average this season, .323 OBP and .438 slugging percentage. Arizona’s pitching staff has a 4.45 ERA and 1.33 WHIP. Geraldo Perdomo leads the Diamondbacks with 150 hits, adding a team-high 90 RBI. Ketel Marte is the team’s best hitter with a .288 batting average. Corbin Carroll leads the team in home runs with 28.

Brandon Pfaadt (R) is the projected starting pitcher for the Diamondbacks, and he has a 12-8 record, 5.33 ERA and 1.39 WHIP.

Boston Red Sox Preview

The Boston Red Sox have a 78-64 record this season and are sitting on the third place of the AL East. The Red Sox have a 34-36 road record and are 70-69 in over/under. They are coming off a 5-10 road defeat by the Dbacks, and have back-to-back losses. They are 5-1 to the over in their last 6 games and are playing the Athletics and the Yankees next.

The Red Sox have a .254 batting average this season, .325 OBP and .426 slugging percentage. Boston’s pitching staff has a 3.78 ERA and 1.30 WHIP.  Jarren Duran leads the Red Sox with 140 hits, while Trevor Story is the team’s best hitter, with a .259 batting average. He also leads the team in RBI, with 88, adding a team-high 23 home runs.

Lucas Giolito (R) is the projected starting pitcher for the Red Sox, and he has a 10-2 record, 3.38 ERA and 1.23 WHIP.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last four games as underdogs against the Red Sox.
• The Red Sox have lost four of their last five games as favorites against National League opponents.
• The Diamondbacks have covered the run line in each of their last eight games as underdogs.
• The Red Sox have failed to cover the run line in each of their last six Saturday night games as road favorites against National League opponents.
• The Diamondbacks have led after 5 innings in each of their last six home games against AL East opponents.
• The Diamondbacks have led after 3 innings in six of their last seven home games.
• The Diamondbacks have won the first inning in six of their last seven home games.

Why the Boston Red Sox will win

• The Red Sox have won each of their last four road games after playing the previous day.
• The Diamondbacks have lost four of their last five night games against AL East opponents.
• The Red Sox have covered the run line in five of their last six games as road favorites against National League opponents.
• The Diamondbacks have failed to cover the run line in eight of their last 10 home games against American League opponents after playing the previous day.
• The Diamondbacks have trailed after 3 innings in three of their last four night games against AL East opponents that held a winning record.
• The Diamondbacks have lost the first inning in three of their last four night games against AL East opponents that held a winning record.
• The Diamondbacks have trailed after 5 innings in three of their last four games as underdogs against American League opponents.

Total Runs Facts

• Each of the Diamondbacks’ last six games against AL East opponents have gone OVER the total runs line.
• Seven of the Red Sox’s last eight road games against NL West opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Red Sox’s last nine Saturday games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Diamondbacks’ last 10 night games against AL East opponents.

Matchup/League Facts

• The Diamondbacks rank 2nd in the league for triples this season (34).
• The Diamondbacks rank T2nd in the league for RBIs this season (685).
• The Red Sox rank 1st in the league for doubles this season (286).
• The Red Sox rank 4th in the league for hits this season (1239).

Red Sox vs Diamondbacks Prediction

The Dbacks have won their last five head-to-head meetings against the Red Sox, but the Red Sox are 3-2 in their last 5 visits in Arizona. Over is 3-1 in their last 4 meetings.

In this Red Sox vs Diamondbacks Prediction, the Red Sox are coming as -115 road favorites. Giolito takes the mound for the Red Sox, and he has been excellent lately, with a 4-1 record and 2.73 ERA across his last five starts. He has also been better on the road, with a 3.23 road ERA, while Pfaadt has been struggling this season for the Dbacks. Pfaadt also comes into this matchup in poor form, with 10 earned runs in 6.3 innings pitched across his last two starts. the Red Sox also have a superior bullpen, so I like them to get the road win today in a very good price.