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Red Sox vs Orioles Prediction 5/24/25 MLB Picks Today

Baltimore Orioles (16-33) vs. Boston Red Sox (26-26)
May 24, 2025 1:05 pm EDT
The Line: Boston Red Sox -115 / Baltimore Orioles -105; Over/Under: 9.5
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The Baltimore Orioles and Boston Red Sox meet Saturday in a MLB doubleheader at Fenway Park. Here’s a Red Sox vs Orioles Prediction. This article will include a Red Sox vs Orioles Pick.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 16-33 on the year and play the Cardinals, White Sox, and Mariners next. The Baltimore Orioles are batting .235 on the season, have a .301 OBP, and a .389 slugging percentage. The Baltimore Orioles pitching staff has a 5.75 ERA and a 1.51 WHIP. Gunnar Henderson leads the Baltimore Orioles with 45 hits and 13 RBI, while Ryan O’Hearn and Jackson Holliday have combined for 87 hits and 37 RBI.

Zach Eflin and TBD get the ball for the Baltimore Orioles.

Boston Red Sox Betting Preview

The Boston Red Sox are 26-26 on the year and play the Brewers, Braves, and Angels next. The Boston Red Sox are batting .257 on the season, have a .329 OBP, and a .428 slugging percentage. The Boston Red Sox pitching staff has a 4.05 ERA and a 1.35 WHIP. Alex Bregman leads the Boston Red Sox with 59 hits and 35 RBI while Jarren Duran and Rafael Devers have combined for 117 hits and 79 RBI.

Hunter Dobbins and Lucas Giolito get the ball for the Boston Red Sox.

Why the Boston Red Sox will win

  • The Orioles have lost each of their last 10 games as underdogs on the first leg of a doubleheader.
  • The Red Sox have won four of their last five games against the Orioles.
  • The Red Sox have covered the run line in eight of their last nine games against American League opponents.
  • The Orioles have failed to cover the run line in seven of their last eight day games against American League opponents.
  • The Red Sox have led after 3 innings in five of their last six day games against opponents that held a losing record.
  • The Red Sox have led after 5 innings in five of their last six games against AL East opponents.

Why the Baltimore Orioles will win

  • The Orioles have won each of their last nine games against AL East opponents following a road loss.
  • The Red Sox have lost eight of their last nine games as favorites against AL East opponents following a home win.
  • The Orioles have covered the run line in each of their last 11 road games against AL East opponents following a road loss.
  • The Red Sox have failed to cover the run line in nine of their last 10 games as home favorites against AL East opponents following a win.
  • The Orioles have led after 5 innings in five of their last six day games against the Red Sox.
  • The Red Sox have trailed after 3 innings in each of their last five games as favorites.

Boston Red Sox Player Prop Facts

  • Rafael Devers has hit at least one home run in each of the Red Sox’s last four day games.
  • Rafael Devers has recorded at least one RBI in seven of the Red Sox’s last eight day games.
  • Jarren Duran has scored at least one run in seven of his eight previous home appearances against the Orioles after playing the previous day.
  • Abraham Toro has recorded at least one hit in each of his last 10 appearances against the Orioles.
  • Masataka Yoshida has recorded a Double in three of his last four appearances with the Red Sox as home favorites against AL opponents.
  • Ceddanne Rafaela has recorded at least one Single in each of the Red Sox’s last six games as favorites against AL opponents.
  • Rafael Devers ranks 5th amongst qualified players for On Base Percentage (.415) this season.

Baltimore Orioles Player Prop Facts

  • Ramon Laureano has recorded at least one Double in three of his last four appearances with the Orioles as underdogs against AL opponents.
  • Ryan Mountcastle has recorded at least one RBI in four of the Orioles’ last five games against AL East opponents.
  • Ramon Urias has recorded at least one Single in each of his last eight Saturday day appearances.
  • Ramon Urias has recorded at least one hit in each of his last six appearances with the Orioles as road underdogs.
  • Jordan Westburg has hit a home run in each of his two previous appearances with the Orioles as road underdogs against the Red Sox.
  • Tyler O’Neill has scored at least one run in each of his last eight Saturday appearances with his team as an underdog.
  • Zach Eflin has recorded a win in each of his last three road appearances.
  • Ryan O’Hearn ranks 6th amongst qualified players for On Base Percentage (.403) this season.

Red Sox vs Orioles Prediction

Game 1 Prediction: The Orioles continue to rack up the losses and have won just three games since May 3. Eflin doesn’t provide much confidence, considering he’s allowed 15 hits and 10 runs in his last 10.1 innings. Eflin has allowed 16 runs in 28.1 innings this season overall. With the way the Red Sox swung the bats yesterday, this should be BBQ chicken. Give me the Red Sox to take game 1.

Game 2 Prediction: I’m not excited to get behind Giolito, who has allowed 20 hits and 13 runs in his last 14.1 innings, but the Red Sox have still won his last two starts. Giolito has had some real stinkers throughout his career. Still, the Orioles are the most disappointing team in baseball and not a team I trust at all. Rough pitcher and all, I’m siding with the Red Sox to sweep the doubleheader on Saturday.

Randy Chambers's Free Pick: Game 1: Boston Red Sox / Game 2: Boston Red Sox

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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