Reds vs Cardinals Prediction 9/17/25 MLB Picks Today

In this article, we will formulate a Reds vs Cardinals Prediction for this MLB game on Wednesday, September 17^th at the Busch Stadium the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 74-78 record this season and are sitting on the 4^th place of the NL Central. The Cardinals have a 42-35 home record and are 76-68 in over/under. They are coming off a 3-0 home victory over the Reds, and are 2-6 in their last 8 games. They are playing the Brewers and the Giants next.

The Cardinals have a .245 batting average this season, .314 OBP and .378 Slugging percentage. Saint Louis’ pitching staff has a 4.28 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 131 hits, and he is the team’s best hitter with a .283 batting average. Wilson Contreras leads the team in RBI, with 80, adding a team-high 20 home runs.

Andre Pallante (R) is the projected starting pitcher for the Cardinals, and he has a 6-14 record, 5.34 ERA and 1.43 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have a 75-76 record this season and are sitting in the third place of the NL Central. The Reds have a 35-42 road record and are 57-86 in over/under. They are coming off a 0-3 road defeat by the Cardinals, and are 1-3 in their last 4 games. Under is 6-2-1 in their last 9 games and are playing the Pirates and the Cubs next.

The Reds have a .245 batting average this season, .316 OBP and .391 slugging percentage. Cincinnati’s pitching staff has a 3.99 ERA and 1.24 WHIP.  Elly De La Cruz leads the Reds with 156 hits, and in RBI, with 82, adding a team-high 19 home runs. He is also the team’s best hitter with a .264 batting average.

Brady Singer (R) is the projected starting pitcher for the Reds, and he has a 13-10 record, 3.94 ERA and 1.24 WHIP.

Cincinnati Reds @ St. Louis Cardinals Betting Trends: September 17, 2025

• Probable Starting Pitcher: Andre Pallante      Record this season: 6-14      ERA: 5.23
• Home Record: 4-6
• Last 5 against Reds: 2-3

Why the St. Louis Cardinals will win

• The Reds have lost each of their last nine Wednesday games as favorites against NL Central opponents.
• The underdogs have won seven of the Cardinals’ last eight games at Busch Stadium.
• The underdogs have covered the run line in each of the Cardinals’ last eight games at Busch Stadium.
• The Reds have failed to cover the run line in each of their last 12 Wednesday games as favorites against NL Central opponents.
• The Reds have lost the first inning in four of their last five road games against National League opponents that held a losing record.
• The Reds have trailed after 5 innings in four of their last five road games against National League opponents that held a losing record.
• The Reds have trailed after 3 innings in four of their last five road games against National League opponents that held a losing record.

• Probable Starting Pitcher: Brady Singer      Record this season: 13-10      ERA: 3.94
• Road Record: 5-6
• Last 5 against Cardinals: 1-3

Why the Cincinnati Reds will win

• The Reds have won each of their last six day games against National League opponents following a loss.
• The Cardinals have lost each of their last seven Wednesday games against National League opponents that held a losing record.
• The Cardinals have failed to cover the run line in each of their last eight home games against National League opponents following a home win.
• The Reds have covered the run line in each of their last five games against National League opponents following a loss.
• The Cardinals have trailed after 5 innings in three of their last four games against opponents that held a losing record.

Total Runs Facts

• Thirteen of the Reds’ last 15 day games against National League opponents have gone UNDER the total runs line.
• Each of the Cardinals’ last four games as home underdogs have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Reds’ last four games as favorites against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last six Wednesday games against National League opponents.

St. Louis Cardinals Player Prop Facts

• Nolan Arenado has hit a home run in five of his last 11 appearances with his team as a home underdog against the Reds.
• Brendan Donovan has recorded a Double in three of his last four appearances in day games against NL Central teams that held a losing record.
• Masyn Winn has recorded at least one hit in each of his last nine Wednesday appearances with the Cardinals as underdogs.
• Victor Scott II ranks T10th in the league in Steals (32) this season.

Cincinnati Reds Player Prop Facts

• Jose Trevino has recorded a Double in three of his last four road appearances against the Cardinals.
• Brady Singer has recorded a win in each of his last four appearances with the Reds as favorites.
• Brady Singer has recorded eight or more strikeouts in each of his last five appearances in day games.
• Elly De La Cruz has recorded at least one hit in each of the Reds’ last nine games against NL Central opponents.
• Miguel Andujar has hit a home run in each of his last two appearances in day games against NL Central teams that held a losing record.
• Elly De La Cruz ranks T7th in the league in Steals (35) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1126).
• The Reds rank 23rd in the league for home runs this season (152).
• The Reds rank 8th in the league for opponent batting average this season (.237).

Reds vs Cardinals Prediction

Both teams are tied 3-3 in their last 6 meetings, and 2-2 in their last 4 meetings in Saint Louis.

In this Reds vs Cardinals Prediction, the Reds are coming as -115 road favorites. Singer for the Reds is the better pitching option in this matchup, and he has been in excellent form lately, with a 4-1 record and 2.40 ERA across his last 5 starts. On the flip side, Pallante has been terrible at home, with a 5.67 home ERA, and he has been struggling lately, with a 1-4 record and 6.15 ERA across his last 5 starts. the Reds also have the better offense to offer Singer run support, and are better against right-handed pitching. Take the Cincinnati Reds for the bounce-back win on the road in this one.