Reds vs Cardinals Prediction 4/29/25 MLB Picks Today

In this article, we will formulate a Reds vs Cardinals Prediction for this MLB game on Tuesday, April 29th, at the Great American Ballpark.  Let’s take a look at a Cincinnati Reds vs St. Louis Cardinals pick. 

Another Bad Offensive Game for the Cardinals

It was another bad offensive game for the Cardinals on Monday, and they have to find a way to get the offense going earlier. The Cardinals scored a run in the top of the first inning and then went eight innings without scoring another run on the way to the defeat. Nolan Arenado finished with one hit and one RBI. Andre Pallante got the start, and he went six innings, giving up six hits and three runs. 

The Cardinals are averaging 4.52 runs while their pitching is giving up 4.65 runs per game. The offense is ranked 12th while the pitching is ranked 22nd. Ivan Herrera has hit four home runs and driven in 11 RBIs. Getting the start for the Cardinals will be Miles Mikolas, who sits with a 0-2 record and an ERA of 5.70. Against the Atlanta  Braves in his last start, he went six innings, giving up six hits and zero runs. 

Strong Pitching for the Reds

It was some strong pitching for the Reds on Monday, and that was enough for the 3-1 victory. Nick Martinez had a strong start, going six innings, giving up five hits and one run. The bullpen then came in, including Graham Ashcraft, who went an inning and had three strikeouts. Jose Trevino hit a home run. The Reds have won five games in a row, and it really appears that they are heating up in a big way. 

The Reds are averaging 5.28 runs while their pitching is giving up 3.79 runs per game. The offense is ranked 4th while the pitching is ranked 10th. This team probably isn’t getting enough attention for how well they have played this season. Elly De La Cruz has hit five home runs and driven in 24 RBIs. Getting the start for the Reds will be Brady Singer, who sits with a 4-0 record and an ERA of 3.62. Against the Miami Marlins in his last start, he went six innings, giving up four hits and two runs. 

Why the Reds Will Beat the Cardinals

• The Cardinals have lost eight of their last nine road games.
• The Reds have won seven of their last eight home games against NL Central opponents.
• The Reds have covered the run line each of their last eight night games against NL Central opponents that held a losing record.
• The Cardinals have failed to cover the run line in seven of their last eight games against NL Central opponents.
• The Cardinals have trailed after 5 innings in four of their last five games against National League opponents that held a winning record.

Total Run Facts

• Eight of the last nine games between the Cardinals and Reds at Great American Ball Park have gone UNDER the total runs line.
• Four of the Cardinals’ last five games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Cardinals’ last eight night games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Reds’ last four home games.

Reds vs Cardinals Prediction

The Reds are going to have no issue getting the job done. Yes, Miles Mikolas was good in his last start, but don’t let that fool you; he still sits with an ERA of 5.70. For Brady Singer, he has been dominant, and the Cardinals’ offense has zero confidence right now. The Reds’ offense is going to be teeing off on Mikolas early and often, and it’s going to be a blowout victory by Cincinnati. Back the Reds on the run line.