Reds vs Cardinals Prediction 5/23/26 MLB Picks Today
St. Louis Cardinals (28-21) vs. Cincinnati Reds (26-24)
May 23, 2026 1:10 pm EDT
The Line: Cincinnati Reds -112 / St. Louis Cardinals -108; Over/Under: 9.5
(Get latest betting odds)
The St. Louis Cardinals and Cincinnati Reds meet Saturday in an MLB doubleheader at Great American Ball Park. Here’s a Reds vs. Cardinals Prediction. This article will include a Reds vs. Cardinals Pick.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 28-21 on the year and play the Cubs and Brewers next. The St. Louis Cardinals are batting .240 on the season and have a .320 OBP, and a .389 slugging percentage. The St. Louis Cardinals pitching staff has a 4.24 ERA and a 1.38 WHIP. Alec Burleson leads the St. Louis Cardinals with 54 hits and 34 RBI while Jordan Walker and Ivan Herrera have combined for 102 hits and 59 RBI.
The St. Louis Cardinals will throw out Andre Pallante and Kyle Leahy.
Cincinnati Reds Betting Preview
The Cincinnati Reds are 26-24 on the year and play the Mets and Braves next. The Cincinnati Reds are batting. 229 on the season, have a .312 OBP, and have a .394 slugging percentage. The Cincinnati Reds pitching staff has a 4.71 ERA and a 1.46 WHIP. Elly De La Cruz leads the Cincinnati Reds with 58 hits and 32 RBI, while Sal Stewart and Spencer Steer have combined for 97 hits and 52 RBI.
The Cincinnati Reds will throw out Chris Paddack and Chase Petty.
Why the Cincinnati Reds will win
- The Reds have won each of their last nine home games against teams that held a winning record.
- The Cardinals have lost each of their last five day games against National League opponents.
- The Reds have covered the run line in seven of their last eight games against National League opponents that held a winning record.
- The Cardinals have failed to cover the run line in five of their last six day games against NL Central opponents.
- The Cardinals have lost the first inning in three of their last four day games.
- The Reds have led after 3 innings in four of their last five home games against opponents that held a winning record.
- The Reds have led after 5 innings in each of their last five home day games.
Why the St. Louis Cardinals will win
- The Reds have lost each of their last nine games against NL Central opponents.
- The Cardinals have won seven of their last eight games as road underdogs following a loss.
- The Cardinals have covered the run line in each of their last eight road games following a loss.
- The Reds have failed to cover the run line in each of their last six games as favorites on the first leg of a doubleheader.
- The Cardinals have won the first inning in each of their last three games as underdogs against the Reds.
- The Cardinals have led after 3 innings in each of their last three road games against NL Central opponents.
- The Cardinals have led after 5 innings in four of their last five games at Great American Ball Park against opponents that held a winning record.
Total Runs Facts
- Each of the Reds’ last six home games against National League opponents has gone OVER the total runs line.
- Each of the Cardinals’ last four road games against National League opponents has gone UNDER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last seven games as favorites against NL Central opponents.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last four daytime games.
Cincinnati Reds Player Prop Facts
- Chris Paddack has recorded four or more strikeouts in five of his last six appearances in day games.
- Spencer Steer has recorded at least one hit in each of the Reds’ last 16 games against NL opponents.
- Ke’Bryan Hayes has hit a home run in three of his last four home appearances against the Cardinals after not playing the previous day.
- Sal Stewart is one of only two players to record 10+ Home Runs and 10+ Stolen Bases this season.
St. Louis Cardinals Player Prop Facts
- Alec Burleson has hit a home run in four of the Cardinals’ last 14 games against NL opponents.
- Masyn Winn has recorded at least one hit in each of his last seven road appearances after not playing the previous day.
- Jordan Walker ranks 7th amongst qualified players for Slugging Percentage (.563) this season.
Matchup/League Facts
- The Reds rank 28th in the league for walks allowed this season (231).
- The Reds rank 27th in the league for hits this season (384).
- The Cardinals rank 30th in the league for strikeouts this season (358).
- The Cardinals rank T29th in the league for triples this season (2).
Reds vs Cardinals Prediction
Game 1 Prediction: I’m not getting behind Paddack, who has been arguably the worst pitcher in baseball this season and was just DFA by the Marlins. In his last 7.2 innings, he’s allowed 12 hits and 9 runs. Through 35.2 innings, Paddack has a 7.07 ERA, 1.63 WHIP, and is allowing a .305 batting average. I don’t care who is on the other side. I’m fading, Paddack. Give me the Cards.
Game 2 Prediction: Petty has just 5.2 innings under his belt this season and will make just his fourth career start. Leahy has been respectable this season and that includes allowing 13 hits and 2 runs in his last 16.1 innings. Leahy still has to limit his walks, but he’s pitching his best this month. It’s hard to sweep doubleheaders but give me the Cardinals in both games.