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Reds vs Cardinals Prediction 8/17/26 MLB Picks Today

St. Louis Cardinals (63-61) vs. Cincinnati Reds (59-64)
August 17, 2026 1:40 pm EDT
The Line: Cincinnati Reds / St. Louis Cardinals ; Over/Under:
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In this article we will formulate a Reds vs Cardinals prediction for this MLB game on Monday, August 17th at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 59-64 this year after they lost two out of three against the Marlins by scores of 1-0, 4-8, and 1-7. In game three, Cincinnati allowed two runs in the eighth inning and five more in the ninth in the loss. The Reds recorded four hits and they committed three errors in the game, while they were led by Stephenson, who went 1-1 with one home run and one RBI. Lodolo allowed three hits and zero earned runs over 5.0 innings, while Antone picked up the loss in relief. Prior to that series, Cincinnati won two out of three against the White Sox, but lost all three against the Nationals before that. 

This season, Cincinnati has a 4.51 ERA with a 1.40 WHIP and a .246 opponent batting average, while they have scored 502 runs with a .226 batting average and a .306 on base percentage. Sal Stewart has led the Reds with 26 home runs and 91 RBIs, while Elly De La Cruz has added 20 home runs and 56 RBIs. The projected starting pitcher for Cincinnati in game one is TBD. The projected starter for game two is Rhett Lowder, who is 4-8 with a 5.15 ERA and a 1.48 WHIP over 94.1 innings pitched this year. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 63-61 this season after they won two out of three against the Cubs by scores of 0-3, 8-4, and 11-4. In game three, St. Louis had their lead cut to 3-2 in the third inning, but they scored the next eight runs to seal the win. The Cardinals recorded 13 hits in the game and they were led by Walker, who went 3-4 with one home run and four RBIs. Dobbins allowed two hits and two earned runs over 5.0 innings for the win, while Ferguson allowed one earned run in relief. Prior to that series, St. Louis won two out of three against the Phillies and two out of three against the Rockies. 

This season, St. Louis has a 4.04 ERA with a 1.34 WHIP and a .252 opponent batting average, while they have scored 548 runs with a .240 batting average and a .316 on base percentage. Jordan Walker has led the Cardinals with 24 home runs and 88 RBIs, while Alec Burleson has added 21 home runs and 90 RBIs. The projected starting pitcher for St. Louis in game one is Quinn Mathews, who is 0-1 with a 3.60 ERA and a 1.80 WHIP over 5.0 innings pitched. The projected starter for game two is Andre Pallante, who is 12-6 with a 3.46 ERA and a 1.22 WHIP over 130.0 innings pitched this season. 

Why the Cincinnati Reds will win

  • The Cardinals have lost nine of their last 10 road games against NL Central opponents that held a losing record.
  • The Reds have won each of their last seven Monday day games.
  • The Cardinals have failed to cover the run line in seven of their last eight day games against the Reds following a win.
  • The Reds have covered the run line in 12 of their last 13 Monday home games against NL Central opponents.
  • The Cardinals have trailed after 3 innings in each of their last three games at Great American Ball Park against opponents that held a losing record.
  • The Reds have led after 5 innings in each of their last seven Monday day games.

Why the St. Louis Cardinals will win

  • The Reds have lost nine of their last 10 home games on the first leg of a doubleheader.
  • The Cardinals have won each of their last five day games after playing the previous day.
  • The Cardinals have covered the run line in each of their last seven games on the first leg of a doubleheader against National League opponents.
  • The Reds have failed to cover the run line in each of their last six home games.
  • The Cardinals have led after 3 innings in four of their last five games against National League opponents that held a losing record.
  • The Cardinals have led after 5 innings in five of their last six day games.

Total Runs Facts

  • Each of the last four games between the Cardinals and Reds have gone UNDER the total runs line.
  • Eight of the Cardinals’ last 10 road games on the first leg of a doubleheader have gone UNDER the total runs line.
  • There has been no run scored during the first inning in each of the Reds’ last five games against National League opponents.
  • There has been no run scored during the first inning in six of Andre Pallante’s last seven appearances as a starter.

Cincinnati Reds Player Prop Facts

  • Tyler Stephenson has hit a home run in four of the Reds’ last five day games.
  • Sal Stewart has recorded at least one hit in each of the Reds’ last 13 games against NL Central opponents that held a winning record.
  • Rhett Lowder has recorded five or more strikeouts in three of his four previous home appearances against NL Central opponents that held a winning record.

St. Louis Cardinals Player Prop Facts

  • Nathan Church has recorded at least one hit in each of his last 10 appearances after playing the previous day.
  • Andre Pallante has recorded a win in seven of his last eight road appearances.
  • Andre Pallante has recorded five or more strikeouts in each of his last six appearances against opponents that held a losing record.
  • Alec Burleson has hit a home run in each of the Cardinals’ last three road games against NL opponents that held a losing record.

Matchup/League Facts

  • The Reds rank 30th in the league for hits this season (925).
  • The Reds rank 30th in the league for batting average this season (.226).
  • The Cardinals rank 28th in the league for doubles this season (176).
  • The Cardinals rank T3rd in the league for home runs allowed this season (122).

Reds vs Cardinals Prediction 

St. Louis comes into this matchup after winning a series against the Cubs and they have won four of their last five games. The Cardinals are 31-27 on the road this year, while the Reds are 30-33 at home. Cincinnati has lost three of their last five and they have allowed 7+ runs in three of their last four. We don’t know who is starting for Cincinnati in game one, but I like the Cardinals to win both games, as they are the better offensive team and I like how their pitching is set up. 

David Racey's Free Pick: Game 1: Cardinals ML Game 2: Cardinals ML

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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