Reds vs Cardinals Prediction 8/31/25 MLB Picks Today

The Cincinnati Reds and St. Louis Cardinals meet Sunday in MLB action from the Great American Ballpark. Here’s a Reds vs Cardinals prediction. We will look at this from a betting perspective and determine the best Cincinnati and St. Louis pick. 

Cardinals Are Hot

The Cardinals are on fire heading into this game and they have won three games in a row. In the first game on Friday they secured the 7-5 victory, and on Saturday, it was the pitching that allowed them to pick up the 4-2 win. Michael McGreevy went six innings, giving up five hits and one run. JoJo Romero went 1.1 innings out of the bullpen and he gave up zero runs and zero hits. The bullpen is going to need to be good in a major way again here. Center field Nathan finished with two RBIs. Wilson Conteras also hit a key home run that helped pace the offense. 

Getting the start for the Cardinals in this game is going to be Andre Pallante who sits with a 6-12 record and an ERA of 5.44. In his last start against the Pittsburgh Pirates he was awful, going five innings giving up eight hits and seven runs. He gave up one home run and also walked one runner. 

Why the Cardinals Will Beat the Reds

• The underdogs have won each of the last five games between the Cardinals and Reds at Great American Ball Park.
• The Reds have lost each of their last four games as home favorites against the Cardinals following a loss.
• The Reds have failed to cover the run line in each of their last seven games as home favorites.
• The underdogs have covered the run line in each of the Cardinals’ last five games at Great American Ball Park.
• The Cardinals have led after 5 innings in four of their last five games against the Reds at Great American Ball Park.

Reds Back to .500

The Reds are suddenly back to .500 after losing the last couple of games against St. Louis. On Friday, the pitching struggled, and on Saturday, the offense wasn’t good enough as they scored only two runs. Gavin Lux was the top offensive player finishing with one hit, one walk, and one RBI. Matt McClain also hit a solo home run. On Friday, the Reds hit three home runs, and leaning on the longball here would also be very helpful. 

Getting the start for the Reds in this game will be Brady Singer and he sits with an 11-9 record and an ERA of 4.06. In his last start against the Arizona Diamondbacks, he went six innings giving up one hit and one run. Over his last three starts, he has gone 18 innings total and given up only two runs. The Reds really need Singer to dominate this game. On Monday, the Reds are going to face off against the Toronto Blue Jays at home. 

Why the Reds Will Beat the Cardinals

• The Reds have won each of their last seven day games at Great American Ball Park following a loss.
• The Cardinals have lost 10 of their last 11 day games against NL Central opponents following a road win.
• The Cardinals have failed to cover the run line in five of their last six day games against the Reds at Great American Ball Park following a win.
• The Reds have covered the run line in four of their last five day games against the Cardinals following a loss.
• The Reds have won the first inning in each of their last three games as favorites against the Cardinals.

Reds vs Cardinals Prediction

The Reds are going to have no issue getting the job done in this game, because of the pitching. We have saw what Singer has done his last three starts, and he’s going to dominate again here. Over those three starts he as given up only two runs total. Compare that to Pallante on the other side who gave up seven runs and eight hits in his last start. The Reds scored five runs on Friday, and they will score even more than that here. The Cardinals won’t score more than two or three runs total, and the Reds will come out ahead. Back the Reds on the money line.