Reds vs Cardinals Prediction 9/15/25 MLB Picks Today

In this article, we will formulate a Reds vs Cardinals Prediction for this MLB game on Monday, September 15^th at the Busch Stadium the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 73-77 record this season and are sitting on the 4^th place of the NL Central. The Cardinals have a 41-34 home record and are 75-67 in over/under. They are coming off a 3-2 road victory over the Brewers, that snapped their five-game losing streak. They are playing the Brewers and the Giants next.

The Cardinals have a .245 batting average this season, .314 OBP and .379 Slugging percentage. Saint Louis’ pitching staff has a 4.28 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 128 hits, and he is the team’s best hitter with a .281 batting average. Wilson Contreras leads the team in RBI, with 79, adding a team-high 20 home runs.

Matthew Liberatore (R) is the projected starting pitcher for the Cardinals, and he has a 7-12 record, 4.35 ERA and 1.33 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have a 74-75 record this season and are sitting in the third place of the NL Central. The Reds have a 34-41 road record and are 56-85 in over/under. They are coming off a 5-11 road defeat by the A’s, and have back-to-back losses. Under is 5-1-1 in their last 7 games and are playing the Pirates and the Cubs next.

The Reds have a .246 batting average this season, .316 OBP and .391 slugging percentage. Cincinnati’s pitching staff has a 3.98 ERA and 1.24 WHIP.  Elly De La Cruz leads the Reds with 154 hits, and in RBI, with 82, adding a team-high 19 home runs. He is also the team’s best hitter with a .263 batting average.

Zack Littell (R) is the projected starting pitcher for the Reds, and he has a 9-8 record, 3.78 ERA and 1.12 WHIP.

Cincinnati Reds @ St. Louis Cardinals Betting Trends: September 15, 2025

• Probable Starting Pitcher: Matthew Liberatore      Record this season: 7-12      ERA: 4.35
• Home Record: 5-5
• Last 5 against Reds: 0-1

Why the St. Louis Cardinals will win

• The Reds have lost each of their last seven night games against teams that held a losing record.
• The Cardinals have won each of their last eight Monday home games against NL Central opponents.
• The Reds have failed to cover the run line each of their last six night games against NL Central opponents that held a losing record.
• The Cardinals have covered the run line in each of their last four night games against the Reds following a win.
• The Reds have trailed after 3 innings in five of their last six road games against opponents that held a losing record.
• The Reds have lost the first inning in each of their last three road games against National League opponents that held a losing record.
• The Cardinals have led after 5 innings in each of their last four night games against the Reds.

• Probable Starting Pitcher: Zack Littell      Record this season: 9-8      ERA: 3.78
• Road Record: 7-4
• Last 5 against Cardinals: 0-1

Why the Cincinnati Reds will win

• The underdogs have won five of the Cardinals’ last six games at Busch Stadium.
• The Cardinals have lost nine of their last 11 games as favorites following a win.
• The Cardinals have failed to cover the run line in each of their last 12 games as favorites against National League opponents following a win.
• The underdogs have covered the run line in each of the Cardinals’ last six games at Busch Stadium.
• The Reds have won the first inning in three of their last four games against the Cardinals.
• The Cardinals have trailed after 5 innings in three of their last four home night games.
• The Reds have led after 3 innings in three of their last four road games against National League opponents.

Total Runs Facts

• Seven of the Reds’ last eight games as road underdogs have gone UNDER the total runs line.
• Each of the Cardinals’ last four home games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last five games between the Reds and Cardinals.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last four night games at Busch Stadium.

St. Louis Cardinals Player Prop Facts

• Nolan Arenado has hit a home run in two of his last three appearances with the Cardinals as home favorites against the Reds.
• Nolan Arenado has recorded a hit in each of his last six appearances with the Cardinals as favorites against NL Central opponents.
• Victor Scott II ranks T10th in the league in Steals (32) this season.

Cincinnati Reds Player Prop Facts

• Elly De La Cruz has recorded a Double in three of the Reds’ last four games against the Cardinals.
• Austin Hays has recorded at least one hit in each of the Reds’ last nine night games.
• Will Benson has hit a home run in each of the Reds’ last two games.
• Elly De La Cruz ranks 7th in the league in Steals (35) this season.

Matchup/League Facts

• The Cardinals rank T29th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1109).
• The Reds rank 7th in the league for opponent batting average this season (.236).
• The Reds rank 8th in the league for hits allowed this season (1176).

Reds vs Cardinals Prediction

The Cardinals are 6-3 in their last 9 meetings against the Reds, and are 2-1 their last 3 meetings in Saint Louis.

In this Reds vs Cardinals Prediction, the Cardinals are coming as -125 home favorites. Both teams are in bad form lately, and both pitchers are hard to trust as well. Littell has been better on paper, but he has been struggling lately, with a 4.78 ERA in his last 5 starts. On the flip side, Liberatore has 3+ earned runs in five of his last six starts, but the Reds are terrible against lefties. Saint Louis has a better bullpen and this will be enough to get them the home victory in this matchup. Take the Saint Louis Cardinals as small home favorites in this one.