Reds vs Cubs Prediction 9/20/25 MLB Picks Today

The Chicago Cubs and Cincinnati Reds meet Saturday in MLB action at Great American Ball Park. Here’s a Reds vs Cubs Prediction. This article will include a Reds vs Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 88-66 on the year and play the Mets and Cardinals next. The Chicago Cubs are batting .249 on the season, have a .321 OBP, and a .427 slugging percentage. The Chicago Cubs pitching staff has a 3.82 ERA and a 1.19 WHIP. Nico Hoerner leads the Chicago Cubs with 169 hits and 59 RBI, while Pete Crow-Armstrong and Dansby Swanson have combined for 280 hits and 166 RBI.

Javier Assad gets the ball for the Chicago Cubs, and he is 3-1 with a 4.23 ERA and 15 strikeouts this season. Assad is 0-2 with a 3.16 ERA and 39 strikeouts in his career against the Cincinnati Reds.

Cincinnati Reds Betting Preview

The Cincinnati Reds are 78-76 on the year and play the Pirates and Brewers next. The Cincinnati Reds are batting .245 on the season, have a .316 OBP, and a .392 slugging percentage. The Cincinnati Reds pitching staff has a 3.94 ERA and a 1.24 WHIP. Elly De La Cruz leads the Cincinnati Reds with 157 hits and 83 RBI while TJ Friedl and Spencer Steer have combined for 258 hits and 121 RBI.

Zack Littell gets the ball for the Cincinnati Reds, and he is 9-8 with a 3.86 ERA and 123 strikeouts this season. Littell is 2-0 with a 0.71 ERA and 15 strikeouts in his career against the Chicago Cubs.

The Chicago Cubs @ Cincinnati Reds Betting Trends: September 20, 2025

• Probable Starting Pitcher: Zack Littell      Record this season: 9-8      ERA: 3.86
• Home Record: 2-4
• Last 5 against Cubs: 2-0

Why the Cincinnati Reds will win

• The Reds have won each of their last four games as underdogs against National League opponents.
• The Cubs have lost three of their last four games as favorites against National League opponents following a loss.
• The Reds have covered the run line in each of their last 13 Saturday games as home underdogs.
• The Cubs have failed to cover the run line in four of their last five games following a loss.
• The Reds have won the first inning in each of their last five games as underdogs against the Cubs at Great American Ball Park.
• The Reds have led after 3 innings in 11 of their last 14 games as home underdogs against NL Central opponents.
• The Cubs have trailed after 5 innings in four of their last five games at Great American Ball Park.

• Probable Starting Pitcher: Javier Assad      Record this season: 3-1      ERA: 4.23
• Road Record: 1-1
• Last 5 against Reds: 0-1

Why the Chicago Cubs will win

• The Cubs have won each of their last 10 Saturday night games.
• The Reds have lost four of their last five home games against NL Central opponents following a home win.
• The Cubs have covered the run line each of their last six Saturday night games against teams that held a winning record.
• The Reds have failed to cover the run line in five of their last six games at Great American Ball Park following a win.
• The Cubs have won the first inning in eight of their last nine Saturday games against opponents that held a winning record.
• The Cubs have led after 3 innings in three of their last four night games against opponents that held a winning record.
• The Cubs have led after 5 innings in each of their last six Saturday night games against opponents that held a winning record.

Total Runs Facts

• Nine of the Cubs’ last 10 night games against National League opponents have gone UNDER the total runs line.
• Each of the Reds’ last five games as underdogs against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the last seven games between the Cubs and Reds.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in six of the Cubs’ last seven games as favorites.

Cincinnati Reds Player Prop Facts

• Austin Hays has recorded at least one hit in each of his last 12 appearances in night games.
• Spencer Steer has hit at least one home run in three of his last four appearances with the Reds as underdogs against NL Central opponents.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has recorded at least one Double in five of the Cubs’ last six road games against the Reds.
• Nico Hoerner has recorded at least one hit in each of the Cubs’ last 10 games as favorites.
• Dansby Swanson has hit a home run in three of the Cubs’ last four games as favorites against the Reds.

Matchup/League Facts

• The Reds rank 8th in the league for opponent batting average this season (.236).
• The Reds rank 8th in the league for hits allowed this season (1211).
• The Cubs rank 1st in the league for walks allowed this season (392).
• The Cubs rank 3rd in the league for steals this season (154).

Reds vs Cubs Prediction

The Cubs are the better team, but I don’t trust Assad and his small sample size of 27.2 innings. Assad is still getting his feet wet, and he’s allowed 12 hits and 7 runs in his last 13.2 innings. The Reds have won 3 straight games and are still in the thick of the wilds and race. Littell has been at his best at home, where he has a 3.67 ERA and .258 allowed batting average. These are must-win games for the Reds if they’re going to reach the postseason. Give me the Reds and the pitcher with the larger, more trustworthy sample size.