Reds vs Guardians Prediction 7/27/26 MLB Picks Today
Cleveland Guardians (54-53) vs. Cincinnati Reds (49-55)
July 27, 2026 7:00 pm EDT
The Line: Cincinnati Reds -175 / Cleveland Guardians 144; Over/Under: 8.5
(Get latest betting odds)
The Cleveland Guardians and Cincinnati Reds meet Monday in MLB action at Great American Ball Park. Here’s a Reds vs Guardians Prediction. This article will include a Reds vs Guardians Pick.
Cleveland Guardians Betting Preview
The Cleveland Guardians are 54-53 on the year and play the Diamondbacks and Mets next. The Cleveland Guardians are batting .230 on the season, have a .309 OBP, and have a .371 slugging percentage. The Cleveland Guardians’ pitching staff has a 3.75 ERA and a 1.27 WHIP. Brayan Rocchio leads the Cleveland Guardians with 97 hits and 49 RBI, while Chase DeLauter and Steven Kwan have combined for 176 hits and 68 RBI.
Slade Cecconi gets the ball for the Cleveland Guardians, and he is 4-7 with a 4.60 ERA and 82 strikeouts this season. Cecconi is 0-3 with a 4.05 ERA and 26 strikeouts in his career against the Cincinnati Reds.
Cincinnati Reds Betting Preview
The Cincinnati Reds are 49-55 on the year and play the Athletics and Pirates next. The Cincinnati Reds are batting .230 on the season, have a .308 OBP, and have a .397 slugging percentage. The Cincinnati Reds’ pitching staff has a 4.52 ERA and a 1.42 WHIP. Sal Stewart leads the Cincinnati Reds with 100 hits and 76 RBI, while Elly De La Cruz and Spencer Steer have combined for 175 hits and 87 RBI.
Chase Burns gets the ball for the Cincinnati Reds, and he is 12-1 with a 2.42 ERA and 124 strikeouts this season. This will be Burns’ first career game against the Cleveland Guardians.
Why the Cincinnati Reds will win
- The Guardians have lost each of their last nine games as road underdogs against the Reds following a loss.
- The Reds have won each of their last nine Monday games against American League opponents that held a winning record.
- The Reds have covered the run line in each of their last four home games against the Guardians.
- The Guardians have failed to cover the run line in five of their last six games at Great American Ball Park.
- The Reds have led after 3 innings in three of their last four home games against American League opponents that held a winning record.
- The Reds have led after 5 innings in each of their last nine Monday games against American League opponents that held a winning record.
- The Reds have won the first inning in three of their last four games as favorites against the Guardians at Great American Ball Park.
Why the Cleveland Guardians will win
- The Reds have lost seven of their last eight games as home favorites following a win.
- The underdogs have won each of the Reds’ last five games.
- The Reds have failed to cover the run line in each of their last six games as home favorites following an extra innings win.
- The underdogs have covered the run line in each of the Reds’ last five games.
- The Reds have trailed after 3 innings in four of their last five games against AL Central opponents.
- The Reds have trailed after 5 innings in five of their last six night games at Great American Ball Park against American League opponents.
- The Reds have lost the first inning in three of their last four home games against American League opponents.
Total Runs Facts
- Each of the last seven games between the Guardians and Reds at Great American Ball Park have gone UNDER the total runs line.
- Nine of the Guardians’ last 10 road games against National League opponents have gone UNDER the total runs line.
- There has been no run scored during the first inning in each of the Guardians’ last six games as road underdogs.
- There has been no run scored during the first inning in each of the last six night games between the Guardians and Reds.
Cincinnati Reds Player Prop Facts
- Eugenio Suarez has hit a home run in three of the Reds’ last four night games against opponents that held a winning record.
- Elly De La Cruz has recorded two or more hits in each of his last six appearances with the Reds as favorites against AL opponents.
- Chase Burns has recorded seven or more strikeouts in six of his last seven appearances with the Reds as favorites.
- Chase Burns has recorded a win in each of his last four appearances against opponents that held a winning record.
- Chase Burns ranks T2nd in the league for Wins (12) this season.
Cleveland Guardians Player Prop Facts
- Patrick Bailey has hit a home run in three of his last four appearances against opponents that held a losing record.
- Slade Cecconi has recorded five or more strikeouts in each of his last three road appearances against NL opponents that held a losing record.
- Jose Ramirez has recorded at least one hit in each of the Guardians’ last 12 games against the Reds.
- Jose Ramirez ranks T7th in the league in Steals (24) this season.
Matchup/League Facts
- The Reds rank 30th in the league for hits this season (801).
- The Reds rank 30th in the league for hits this season (801).
- The Guardians rank 30th in the league for slugging percentage this season (.371).
- The Guardians rank 30th in the league for slugging percentage this season (.371).
Reds vs Guardians Prediction
The Reds are coming off a horrible week, and now they’re throwing out a struggling pitcher in Cecconi, who has allowed 22 hits and 11 earned runs in his last 13.1 innings. In 63.2 innings on the road, Cecconi has a 4.81 ERA and a .280 batting average allowed. Burns has been one of the better pitchers in baseball with a 2.42 ERA and 1.11 WHIP, and he has a 2.32 ERA and .190 allowed batting average in 50.1 innings at home. There’s a gap between these teams and on the mound in this particular game. Give me the Reds, and I’ll take the RL to shave down the price.